Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways.
about
The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteinsHIV-1 expression induces cyclin D1 expression and pRb phosphorylation in infected podocytes: cell-cycle mechanisms contributing to the proliferative phenotype in HIV-associated nephropathy.The hunting of the SrcSrc SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transitionThe v-Src SH3 domain facilitates a cell adhesion-independent association with focal adhesion kinase.v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation.Regeneration in avian hair cell epithelia: identification of intracellular signals required for S-phase entry.Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C.Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation.FRNK blocks v-Src-stimulated invasion and experimental metastases without effects on cell motility or growth.Phase II study of saracatinib (AZD0530) in patients with previously treated metastatic colorectal cancer.A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.Global impact of oncogenic Src on a phosphotyrosine proteomeAnsamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.Manipulation of kinase signaling by bacterial pathogensOncogenic PI3K deregulates transcription and translation.Coregulation of multiple signaling mechanisms in pp60v-Src-induced closure of Cx43 gap junction channels.Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.The splicing-factor oncoprotein SF2/ASF activates mTORC1.Phosphorylation of TOPK at Y74, Y272 by Src increases the stability of TOPK and promotes tumorigenesis of colonMiR-424/503-mediated Rictor upregulation promotes tumor progression.Chemopreventive activity of plant flavonoid isorhamnetin in colorectal cancer is mediated by oncogenic Src and β-cateninThe phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications.Mimicking transient activation of protein kinases in living cells.Molecular mechanisms of SH2- and PTB-domain-containing proteins in receptor tyrosine kinase signaling.Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner.v-Src generates a p53-independent apoptotic signal.MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways.Phosphatidylinositol 3'-kinase signalling supports cell height in established epithelial monolayers.Combined silencing of K-ras and Akt2 oncogenes achieves synergistic effects in inhibiting pancreatic cancer cell growth in vitro and in vivo.SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signalingSuppression of v-Src transformation by andrographolide via degradation of the v-Src protein and attenuation of the Erk signaling pathway.Delineating v-Src downstream effector pathways in transformed myoblasts.Subunit S5a of the 26S proteasome is regulated by antiapoptotic signals.Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells.B cell proliferation following CD40 stimulation results in the expression and activation of Src protein tyrosine kinase.Involvement of Src family kinases in N-cadherin phosphorylation and beta-catenin dissociation during transendothelial migration of melanoma cells.Mu-opioid receptor-mediated phosphorylation of IkappaB kinase in human neuroblastoma SH-SY5Y cells.Active Src elevates the expression of beta-catenin by enhancement of cap-dependent translation.The Src-family tyrosine kinase inhibitor PP1 interferes with the activation of ribosomal protein S6 kinases.
P2860
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P2860
Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways.
@en
type
label
Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways.
@en
prefLabel
Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways.
@en
P2860
P356
P1476
Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways.
@en
P2093
P2860
P304
P356
10.1091/MBC.10.6.1693
P577
1999-06-01T00:00:00Z