Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner.
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The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cellsTargeting hyaluronan for the treatment of pancreatic ductal adenocarcinomaRole of hyaluronan in pancreatic cancer biology and therapy: Once again in the spotlightInteractions between Hyaluronan and Its Receptors (CD44, RHAMM) Regulate the Activities of Inflammation and CancerTumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD44-moesin interaction.Cellular processes of v-Src transformation revealed by gene profiling of primary cells--implications for human cancer.CD44 and hyaluronan promote the bone morphogenetic protein 7 signaling response in murine chondrocytes.The role of a new CD44st in increasing the invasion capability of the human breast cancer cell line MCF-7.Hyaluronan stabilizes focal adhesions, filopodia, and the proliferative phenotype in esophageal squamous carcinoma cells.Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration.A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone.4-Methylumbelliferone inhibits ovarian cancer growth by suppressing thymidine phosphorylase expressionIn vivo evidence for the role of CD44s in promoting breast cancer metastasis to the liver.Hyperproduction of hyaluronan in neu-induced mammary tumor accelerates angiogenesis through stromal cell recruitment: possible involvement of versican/PG-M.Hyaluronan-CD44 interaction hampers migration of osteoclast-like cells by down-regulating MMP-9.Hyaluronan regulates ceruloplasmin production by gliomas and their treatment-resistant multipotent progenitorsIntracellular domain fragment of CD44 alters CD44 function in chondrocytes.Hyaluronan-mediated CD44 activation of RhoGTPase signaling and cytoskeleton function promotes tumor progression.Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway.No influence of exogenous hyaluronan on the behavior of human cancer cells or endothelial cell capillary formation.Hyaluronic acid-dependent protection against alkali-burned human corneal cells.Preoperative serum hyaluronic acid level as a prognostic factor in patients undergoing hepatic resection for hepatocellular carcinoma.Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells.Phosphoinositide 3-kinase inhibitor (wortmannin) inhibits pancreatic cancer cell motility and migration induced by hyaluronan in vitro and peritoneal metastasis in vivo.SHAP potentiates the CD44-mediated leukocyte adhesion to the hyaluronan substratum.Tumor cells enhance their own CD44 cleavage and motility by generating hyaluronan fragments.Hyaluronan cell surface binding is induced by type I collagen and regulated by caveolae in glioma cells.Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3.Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells.Hyaluronan oligosaccharides inhibit tumorigenicity of osteosarcoma cell lines MG-63 and LM-8 in vitro and in vivo via perturbation of hyaluronan-rich pericellular matrix of the cells.Hyaluronan and tumor growth.Identification of hyaluronic acid-binding proteins and their expressions in porcine cumulus-oocyte complexes during in vitro maturation.Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone.Hyaluronan oligosaccharides induce CD44 cleavage and promote cell migration in CD44-expressing tumor cells.Stimulation of small proteoglycan synthesis by the hyaluronan synthesis inhibitor 4-methylumbelliferone in human skin fibroblasts.Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2.CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2.Differential effects of hyaluronan and its fragments on fibroblasts: relation to wound healing.Complex roles of the stroma in the intrinsic resistance to gemcitabine in pancreatic cancer: where we are and where we are going.Novel agents for pancreatic ductal adenocarcinoma: emerging therapeutics and future directions.
P2860
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P2860
Hyaluronan activates cell motility of v-Src-transformed cells via Ras-mitogen-activated protein kinase and phosphoinositide 3-kinase-Akt in a tumor-specific manner.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Hyaluronan activates cell moti ...... kt in a tumor-specific manner.
@en
type
label
Hyaluronan activates cell moti ...... kt in a tumor-specific manner.
@en
prefLabel
Hyaluronan activates cell moti ...... kt in a tumor-specific manner.
@en
P2093
P2860
P356
P1476
Hyaluronan activates cell moti ...... kt in a tumor-specific manner.
@en
P2093
M Hamaguchi
N Ishiguro
P2860
P304
P356
10.1091/MBC.12.6.1859
P577
2001-06-01T00:00:00Z