Oncogenic PI3K deregulates transcription and translation. - Wikidata - awgldk - TriplyDB

Oncogenic PI3K deregulates transcription and translation.

Oncogenic PI3K deregulates transcription and translation.

http://www.wikidata.org/entity/Q36337966

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PI3K/AKT/mTOR Pathway in Angiogenesis Should individual PI3 kinase isoforms be targeted in cancer?Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling Comprehensive genomic characterization defines human glioblastoma genes and core pathways Astrocyte elevated gene-1: recent insights into a novel gene involved in tumor progression, metastasis and neurodegeneration Astrocyte elevated gene-1 (AEG-1) is a target gene of oncogenic Ha-ras requiring phosphatidylinositol 3-kinase and c-Myc MicroRNAs as diagnostic and prognostic biomarkers in colorectal cancer Pharmacodynamic Biomarker Development for PI3K Pathway Therapeutics How PI3K-derived lipids control cell division Targeting the PI3K/AKT/mTOR signaling axis in children with hematologic malignancies Idelalisib: First-in-Class PI3K Delta Inhibitor for the Treatment of Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, and Follicular Lymphoma Status of PI3K/Akt/mTOR pathway inhibitors in lymphoma Combined targeting of BRAF and CRAF or BRAF and PI3K effector pathways is required for efficacy in NRAS mutant tumors Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations Novel therapeutic strategies for multiple myeloma AKT and CDK5/p35 mediate brain-derived neurotrophic factor induction of DARPP-32 in medium size spiny neurons in vitro Extract of Pleurotus pulmonarius suppresses liver cancer development and progression through inhibition of VEGF-induced PI3K/AKT signaling pathway Non-invasive imaging of phosphoinositide-3-kinase-catalytic-subunit-alpha (PIK3CA) promoter modulation in small animal models The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation CMZ reversed chronic ethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stress and PGC-1α acetylation, and activating the MAPK and GSK3β pathway BJ-1108, a 6-Amino-2,4,5-Trimethylpyridin-3-ol Analog, Inhibits Serotonin-Induced Angiogenesis and Tumor Growth through PI3K/NOX Pathway Targeting the phosphoinositide 3-kinase pathway in cancer The determinants of head and neck cancer: Unmasking the PI3K pathway mutations HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription.Transcriptional regulation of PIK3CA oncogene by NF-kappaB in ovarian cancer microenvironment.Establishment and characterization of a novel ovarian clear cell adenocarcinoma cell line, TU-OC-1, with a mutation in the PIK3CA gene.Expression of activated PIK3CA in ovarian surface epithelium results in hyperplasia but not tumor formation.Proteomic analysis of phosphoproteins sensitive to a phosphatidylinositol 3-kinase inhibitor, ZSTK474, by using SELDI-TOF MS Data recovery and integration from public databases uncovers transformation-specific transcriptional downregulation of cAMP-PKA pathway-encoding genes.A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate.Capilliposide C Sensitizes Esophageal Squamous Carcinoma Cells to Oxaliplatin by Inducing Apoptosis Through the PI3K/Akt/mTOR Pathway.PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context.Physiological regulation of Akt activity and stability.Valproic acid sensitizes pancreatic cancer cells to natural killer cell-mediated lysis by upregulating MICA and MICB via the PI3K/Akt signaling pathway.PI3K/Akt pathway restricts epithelial adhesion of Dr + Escherichia coli by down-regulating the expression of decay accelerating factor.Pro-oncogenic and anti-oncogenic pathways: opportunities and challenges of cancer therapy.PI3K pathway activation results in low efficacy of both trastuzumab and lapatinib PIK3CA gene mutations and overexpression: implications for prognostic biomarker and therapeutic target in Chinese esophageal squamous cell carcinoma.Regulation of the pentose phosphate pathway in cancer

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P2860

Oncogenic PI3K deregulates transcription and translation.

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Oncogenic PI3K deregulates transcription and translation.

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Oncogenic PI3K deregulates transcription and translation.

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Oncogenic PI3K deregulates transcription and translation.

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Oncogenic PI3K deregulates transcription and translation.

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Oncogenic PI3K deregulates transcription and translation.

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Nature Reviews Cancer

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Oncogenic PI3K deregulates transcription and translation.

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Andreas G Bader

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Sohye Kang

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P2860

Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit

Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle

Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

Mutated PI 3-kinases: cancer targets on a silver platter.

Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins.

Transformation by v-Src: Ras-MAPK and PI3K-mTOR mediate parallel pathways.

Rapamycin induces the G0 program of transcriptional repression in yeast by interfering with the TOR signaling pathway.

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