Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis
about
Kinases as druggable targets in trypanosomatid protozoan parasitesDrug repurposing and human parasitic protozoan diseasesForward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinasesDiscovery of a Carbazole-Derived Lead Drug for Human African TrypanosomiasisNew chemical scaffolds for human african trypanosomiasis lead discovery from a screen of tyrosine kinase inhibitor drugsEVALUATION OF AROMATIC 6-SUBSTITUTED THIENOPYRIMIDINES AS SCAFFOLDS AGAINST PARASITES THAT CAUSE TRYPANOSOMIASIS, LEISHMANIASIS, AND MALARIA.Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei.In vitro screening for drug repositioning.Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery.Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites.Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?Repurposing strategies for tropical disease drug discovery.Glycogen Synthase Kinase 3β Promotes the Endocytosis of Transferrin in the African TrypanosomeDrug discovery and human African trypanosomiasis: a disease less neglected?WIPO Re:Search: a consortium catalyzing research and product development for neglected tropical diseases.Detection and treatment of Trypanosoma cruzi: a patent review (2011-2015).Repurposing of Human Kinase Inhibitors in Neglected Protozoan Diseases.Novel Effects of Lapatinib Revealed in the African Trypanosome by Using Hypothesis-Generating Proteomics and Chemical Biology Strategies.Activity of anti-cancer protein kinase inhibitors against Leishmania spp.AEE788 Inhibits Basal Body Assembly and Blocks DNA Replication in the African Trypanosome.Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery.Establishment of a structure-activity relationship of 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness.Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation.Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT2B/5HT2C Serotonin Receptor Antagonists.Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite ProliferationNovel lead compounds in pre-clinical development against African sleeping sickness
P2860
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P2860
Kinase scaffold repurposing for neglected disease drug discovery: discovery of an efficacious, lapatinib-derived lead compound for trypanosomiasis
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Kinase scaffold repurposing fo ...... d compound for trypanosomiasis
@en
type
label
Kinase scaffold repurposing fo ...... d compound for trypanosomiasis
@en
prefLabel
Kinase scaffold repurposing fo ...... d compound for trypanosomiasis
@en
P2093
P2860
P356
P1476
Kinase scaffold repurposing fo ...... d compound for trypanosomiasis
@en
P2093
Caitlin E Karver
Catherine Sullenberger
Gautam Patel
Kojo Mensa-Wilmot
Norma E Roncal
Peter Edwards
Ranjan Behera
P2860
P304
P356
10.1021/JM400349K
P407
P577
2013-05-03T00:00:00Z