Histone deacetylase inhibitors: molecular mechanisms of action.
about
PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia CellsAcetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1A novel small molecule hydroxamate preferentially inhibits HDAC6 activity and tumour growthHDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulationThe many roles of histone deacetylases in development and physiology: implications for disease and therapyHistone deacetylase inhibitors: Potential in cancer therapyPCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cellsEpigenetic therapy in gastrointestinal cancer: the right combinationEpigenetic Reprogramming of Muscle Progenitors: Inspiration for Clinical TherapiesThe Role of Sulforaphane in Epigenetic Mechanisms, Including Interdependence between Histone Modification and DNA MethylationHistone acetylation: novel target for the treatment of acute lymphoblastic leukemiaHistone deacetylase inhibitors as potential treatment for spinal muscular atrophyTargeting histone deacetylases for cancer therapy: from molecular mechanisms to clinical implicationsEGFR Amplification and Glioblastoma Stem-Like CellsTrials with 'epigenetic' drugs: an updateHDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs?Epigenetics and bacterial infectionsMitochondrial apoptosis and FAK signaling disruption by a novel histone deacetylase inhibitor, HTPB, in antitumor and antimetastatic mouse modelsHistone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell ViabilityStructural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoniMolecular Targets and Emerging Therapeutic Options for Uterine LeiomyosarcomaEpigenome-modifying tools in asthmaThe promise and perils of HDAC inhibitors in neurodegenerationAcetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligaseDietary phytochemicals, HDAC inhibition, and DNA damage/repair defects in cancer cellsSustained improvement of spinal muscular atrophy mice treated with trichostatin A plus nutritionOvercoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound β-phenylethyl isothiocyanateDLC1: a significant GAP in the cancer genomeHealth promoting effects of brassica-derived phytochemicals: from chemopreventive and anti-inflammatory activities to epigenetic regulationTwo new pimelic diphenylamide HDAC inhibitors induce sustained frataxin upregulation in cells from Friedreich's ataxia patients and in a mouse modelHistone deacetylases play a major role in the transcriptional regulation of the Plasmodium falciparum life cycleA novel histone deacetylase inhibitor exhibits antitumor activity via apoptosis induction, F-actin disruption and gene acetylation in lung cancerHDAC inhibition induces increased choline uptake and elevated phosphocholine levels in MCF7 breast cancer cellsInhibition of histone deacetylase impacts cancer stem cells and induces epithelial-mesenchyme transition of head and neck cancerInhibition of histone deacetylase 3 causes replication stress in cutaneous T cell lymphomaPanobinostat enhances cytarabine and daunorubicin sensitivities in AML cells through suppressing the expression of BRCA1, CHK1, and Rad51The anti-tumor histone deacetylase inhibitor SAHA and the natural flavonoid curcumin exhibit synergistic neuroprotection against amyloid-beta toxicityEpigenetic modulation with HDAC inhibitor CG200745 induces anti-proliferation in non-small cell lung cancer cellsIn cortical neurons HDAC3 activity suppresses RD4-dependent SMRT exportPreclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas.
P2860
Q21328686-86D87D28-995B-4DE1-866B-3D7EA7D3FA31Q24301131-4840E066-711A-4D10-8C1D-F27DD335FB53Q24309277-80B93B97-1592-4725-AA45-F05573ACCBFCQ24310722-F482E096-65ED-40A1-A6BA-0D8645A690DEQ24628821-0B758F4C-4732-44DF-B8F7-6E1ECC480492Q24649025-F8DAE016-E543-4419-994E-60ECBC9AC038Q24654958-D966290B-5B4D-4B36-AC99-1EB190751CD5Q26745709-EB3E7DCA-A63F-4DF3-BC17-B220E70DC871Q26770102-863E2F6D-77B8-4266-9D2F-10FEA641FFB4Q26772035-D60E9244-55F2-416A-84BD-5625BE7B7103Q26778780-E4C07016-B3B9-4A26-A815-3151D9B43C3EQ26828876-3105DA87-D301-4FCD-9291-FFA86C0E6DBFQ26853394-F99A3746-E9D9-4B46-94A9-5417B6BC6C95Q26853549-AE15D4AC-208B-410D-AB6A-A8C0579B2C51Q27000542-0BB54ED6-551C-460F-BFDF-2145B8783919Q27015801-AACFCE5E-763A-46A8-987A-30E91A70B802Q27025593-E2281808-350D-48F8-B527-25F5883B8F00Q27310013-1EDD48A8-C25A-4CCB-AA00-55B30E2B9F24Q27679266-A0271B7D-238D-45A9-9E46-31CADDE98B00Q27680126-8F2C8D6F-CE5D-4741-9915-1B9BF37EAAFEQ28076023-C90D6F09-4D8F-4106-9B86-F70B40DAD7EEQ28083520-5325F772-FC41-45D4-AAEB-5A205F1422F4Q28087539-EA918975-4243-4BED-AC76-9EAF56786C4FQ28242315-D788E0FF-94B7-4056-8BC3-E3507933A3BCQ28257534-80FC66BD-DDB7-477C-B7F9-C6FF6B351767Q28288824-A51CEED9-A203-40D5-B924-985800AC7375Q28383320-6039A058-CC81-43A5-AC14-1E0E0FA74F6EQ28390592-8065521D-D696-41D5-BB9E-DAB9C93F2C9CQ28393960-04CF0F08-B356-4D4B-ACEA-BE2A8F2F8A24Q28472583-12145EB2-C42D-47EA-8E87-75F18E6BB5C6Q28472603-78BB02E5-625F-427C-8F6A-48929713EDEEQ28475503-0173678B-1CB3-4BA7-95C7-52FE60EDCEC3Q28486529-933BC9F6-3851-4911-849C-507BB9DAD1AEQ28488474-F650A13B-B37A-4AA3-8615-9D3E77ECF376Q28534761-FE78F326-6C8C-4337-9836-8EBD94560705Q28535006-4B8A8719-1D49-404D-8B60-94DA04CAE2A6Q28538399-7C480FA9-570D-4BB6-B5B8-1BE084318FCDQ28544442-0E188109-D1EB-4CC9-A7E0-0D80249CCE9FQ28568860-4EA4EDF9-F77A-453E-8AC6-FE5DAC40F9DEQ30459589-53FB9D29-1FF9-437C-BBF6-2AA380A23D08
P2860
Histone deacetylase inhibitors: molecular mechanisms of action.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Histone deacetylase inhibitors: molecular mechanisms of action.
@en
type
label
Histone deacetylase inhibitors: molecular mechanisms of action.
@en
prefLabel
Histone deacetylase inhibitors: molecular mechanisms of action.
@en
P2093
P356
P1433
P1476
Histone deacetylase inhibitors: molecular mechanisms of action.
@en
P2093
P2888
P304
P356
10.1038/SJ.ONC.1210620
P407
P577
2007-08-01T00:00:00Z