The membrane glycoprotein of Friend spleen focus-forming virus: evidence that the cell surface component is required for pathogenesis and that it binds to a receptor.
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Overcoming interference to retroviral superinfection results in amplified expression and transmission of cloned genes.Origin and rapid evolution of a novel murine erythroleukemia virus of the spleen focus-forming virus family.An array of novel murine spleen focus-forming viruses that activate the erythropoietin receptor.Env-derived gp55 gene of Friend spleen focus-forming virus specifically induces neoplastic proliferation of erythroid progenitor cells.Activation of erythropoietin receptors by Friend viral gp55 and by erythropoietin and down-modulation by the murine Fv-2r resistance gene.Transmembrane domain of the envelope gene of a polycythemia-inducing retrovirus determines erythropoietin-independent growthFriend Spleen Focus-Forming Virus Activates the Tyrosine Kinase sf-Stk and the Transcription Factor PU.1 to Cause a Multi-Stage Erythroleukemia in Mice.Homologous interference resulting from the presence of defective particles of human immunodeficiency virus type 1.Deletions in one domain of the Friend virus-encoded membrane glycoprotein overcome host range restrictions for erythroleukemia.Cell surface activation of the erythropoietin receptor by Friend spleen focus-forming virus gp55.The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus.The erythropoietin receptor: its role in hematopoiesis and myeloproliferative diseases.A Friend virus mutant encodes a small glycoprotein that causes erythroleukemia.A Friend virus mutant that overcomes Fv-2rr host resistance encodes a small glycoprotein that dimerizes, is processed to cell surfaces, and specifically activates erythropoietin receptors.A constitutively activated erythropoietin receptor stimulates proliferation and contributes to transformation of multipotent, committed nonerythroid and erythroid progenitor cells.A direct demonstration of recombination between an injected virus and endogenous viral sequences, resulting in the generation of mink cell focus-inducing viruses in AKR miceOncogene cooperativity in Friend erythroleukemia: erythropoietin receptor activation by the env gene of SFFV leads to transcriptional upregulation of PU.1, independent of SFFV proviral insertion.Conversion of Friend mink cell focus-forming virus to Friend spleen focus-forming virus by modification of the 3' half of the env gene.Mechanism of leukemogenesis induced by mink cell focus-forming murine leukemia viruses.The hydrophobic membrane-spanning sequences of the gp52 glycoprotein are required for the pathogenicity of Friend spleen focus-forming virus.Friend spleen focus-forming virus induces factor independence in an erythropoietin-dependent erythroleukemia cell line.A deletion in the Friend spleen focus-forming virus env gene is necessary for its product (gp55) to be leukemogenic.Ping-pong amplification of a retroviral vector achieves high-level gene expression: human growth hormone production.The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein.Plasma membrane receptors for ecotropic murine retroviruses require a limiting accessory factor.Leukemogenic membrane glycoprotein encoded by Friend spleen focus-forming virus: transport to cell surfaces and shedding are controlled by disulfide-bonded dimerization and by cleavage of a hydrophobic membrane anchor.Requirement of the single base insertion at the 3' end of the env-related gene of Friend spleen focus-forming virus for pathogenic activity and its effect on localization of the glycoprotein product (gp55).The spleen focus-forming virus (SFFV) envelope gene, when introduced into mice in the absence of other SFFV genes, induces acute erythroleukemia.Isolation of poliovirus 2C mutants defective in viral RNA synthesisA tagged helper-free Friend virus causes clonal erythroblast immortality by specific proviral integration in the cellular genome.Intracellular transport and leukemogenicity of spleen focus-forming virus envelope glycoproteins with altered transmembrane domainsErythropoietin receptor. Subunit structure and activation.c-myc protooncogene expression in mouse erythroleukemia cells.Both the changes of six amino acids and the C-terminal truncation caused by a one-base insertion in the defective env gene of Friend spleen focus-forming virus significantly affect the pathogenic activity of the encoded leukemogenic membrane glycoprMapping of a major osteomagenic determinant of murine leukemia virus RFB-14 to non-long terminal repeat sequences.Erythropoietin receptor (EpoR)-dependent mitogenicity of spleen focus-forming virus correlates with viral pathogenicity and processing of env protein but not with formation of gp52-EpoR complexes in the endoplasmic reticulum.Fusion of the erythropoietin receptor and the Friend spleen focus-forming virus gp55 glycoprotein transforms a factor-dependent hematopoietic cell line.
P2860
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P2860
The membrane glycoprotein of Friend spleen focus-forming virus: evidence that the cell surface component is required for pathogenesis and that it binds to a receptor.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
The membrane glycoprotein of F ...... d that it binds to a receptor.
@en
type
label
The membrane glycoprotein of F ...... d that it binds to a receptor.
@en
prefLabel
The membrane glycoprotein of F ...... d that it binds to a receptor.
@en
P2093
P2860
P1433
P1476
The membrane glycoprotein of F ...... nd that it binds to a receptor
@en
P2093
P2860
P304
P407
P577
1987-09-01T00:00:00Z