Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry
about
Expanding the Described Metabolome of the Marine Cyanobacterium Moorea producens JHB through Orthogonal Natural Products WorkflowsActivity-guided engineering of natural product carrier proteins.Probing the compatibility of type II ketosynthase-carrier protein partners.Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo.Polyketide β-branching in bryostatin biosynthesis: identification of surrogate acetyl-ACP donors for BryR, an HMG-ACP synthaseEvaluating nonpolar surface area and liquid chromatography/mass spectrometry response: an application for site occupancy measurements for enzyme intermediates in polyketide biosynthesis.Convergence of isoprene and polyketide biosynthetic machinery: isoprenyl-S-carrier proteins in the pksX pathway of Bacillus subtilis.Temporal dynamics of natural product biosynthesis in marine cyanobacteria.The identification of bacillaene, the product of the PksX megacomplex in Bacillus subtilis.Natural product biosyntheses in cyanobacteria: A treasure trove of unique enzymes.Bacterial Genome Mining of Enzymatic Tools for Alkyne Biosynthesis.A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis.Chemoenzymatic exchange of phosphopantetheine on protein and peptideTop-down MS, a powerful complement to the high capabilities of proteolysis proteomics.Accessing natural product biosynthetic processes by mass spectrometry.New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria.Strain-specific proteogenomics accelerates the discovery of natural products via their biosynthetic pathwaysFungal cyclooligomer depsipeptides: from classical biochemistry to combinatorial biosynthesis.Insights into the chemical logic and enzymatic machinery of NRPS assembly lines.The Pseudomonas aeruginosa antimetabolite L -2-amino-4-methoxy-trans-3-butenoic acid (AMB) is made from glutamate and two alanine residues via a thiotemplate-linked tripeptide precursor.De novo biosynthesis of terminal alkyne-labeled natural products.Function of the loading module in CorI and of the O-methyltransferase CorH in vinyl carbamate biosynthesis of the antibiotic corallopyronin A.Characterization of AusA: a dimodular nonribosomal peptide synthetase responsible for the production of aureusimine pyrazinones.Biosynthetic multitasking facilitates thalassospiramide structural diversity in marine bacteria.Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry.High-Resolution Tandem Mass Spectrometry for Nonribosomal Peptide and Polyketide Analysis
P2860
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P2860
Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Activity screening of carrier ...... rge molecule mass spectrometry
@en
type
label
Activity screening of carrier ...... rge molecule mass spectrometry
@en
prefLabel
Activity screening of carrier ...... rge molecule mass spectrometry
@en
P2093
P2860
P50
P356
P1433
P1476
Activity screening of carrier ...... rge molecule mass spectrometry
@en
P2093
Christopher T Walsh
Daniel J Edwards
Jonathan Blackhall
Neil L Kelleher
Pieter C Dorrestein
Roberto Kolter
Shaun McLaughlin
William H Gerwick
P2860
P304
P356
10.1021/BI052333K
P407
P577
2006-02-01T00:00:00Z