Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection
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SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathwaysMn porphyrin-based SOD mimic, MnTnHex-2-PyP(5+), and non-SOD mimic, MnTBAP(3-), suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathwaysMetal complexes as potential modulators of inflammatory and autoimmune responses.Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potentialProteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+).Rational design of superoxide dismutase (SOD) mimics: the evaluation of the therapeutic potential of new cationic Mn porphyrins with linear and cyclic substituents.Paradoxical relationship between Mn superoxide dismutase deficiency and radiation-induced cognitive defects.Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.Genistein can mitigate the effect of radiation on rat lung tissue.Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death.Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimicsInvestigations into the role of inflammation in normal tissue response to irradiation.Radioprotection of the brain white matter by Mn(III) n-Butoxyethylpyridylporphyrin-based superoxide dismutase mimic MnTnBuOE-2-PyP5+.Novel synthetic SOD/catalase mimetics can mitigate capillary endothelial cell apoptosis caused by ionizing radiation.Mitigation of lung injury after accidental exposure to radiation.Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumorsNovel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.Anticancer therapeutic potential of Mn porphyrin/ascorbate systemA preclinical rodent model of radiation-induced lung injury for medical countermeasure screening in accordance with the FDA animal rule.A combination of two antioxidants (an SOD mimic and ascorbate) produces a pro-oxidative effect forcing Escherichia coli to adapt via induction of oxyR regulon.Subcutaneous administration of bovine superoxide dismutase protects lungs from radiation-induced lung injury.Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 miceEarly and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damageImpact of SOD-Mimetic Manganoporphyrins on Spin Trapping of Superoxide and Related Artifacts.Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier.Cytokines in radiobiological responses: a review.Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways.Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins.Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumorEffect of ozone oxidative preconditioning in preventing early radiation-induced lung injury in rats.Superoxide dismutase mimic, MnTE-2-PyP(5+) ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum.Radioprotection.Redox-modulated phenomena and radiation therapy: the central role of superoxide dismutases.Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+).Treatment for radiation-induced pulmonary late effects: spoiled for choice or looking in the wrong direction?Modifying radiation damage.Manganese superoxide dismutase, MnSOD and its mimicsPharmacological strategies to spare normal tissues from radiation damage: useless or overlooked therapeutics?ICRP publication 118: ICRP statement on tissue reactions and early and late effects of radiation in normal tissues and organs--threshold doses for tissue reactions in a radiation protection context.
P2860
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P2860
Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Comparison of two Mn porphyrin ...... e in pulmonary radioprotection
@en
type
label
Comparison of two Mn porphyrin ...... e in pulmonary radioprotection
@en
prefLabel
Comparison of two Mn porphyrin ...... e in pulmonary radioprotection
@en
P2093
P2860
P1476
Comparison of two Mn porphyrin ...... e in pulmonary radioprotection
@en
P2093
Benjamin Gauter-Fleckenstein
Chen Jiang
Ines Batinic-Haberle
Katharina Fleckenstein
Kouros Owzar
Zeljko Vujaskovic
P2860
P304
P356
10.1016/J.FREERADBIOMED.2007.10.058
P577
2007-11-21T00:00:00Z