Inhibitor of apoptosis proteins as targets for anticancer therapy.
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Dynamic computational model suggests that cellular citizenship is fundamental for selective tumor apoptosisStructure-Based Design, Synthesis, Evaluation, and Crystallographic Studies of Conformationally Constrained Smac Mimetics as Inhibitors of the X-linked Inhibitor of Apoptosis Protein (XIAP) †cIAP2 promotes gallbladder cancer invasion and lymphangiogenesis by activating the NF-κB pathway.Nonpeptidic and potent small-molecule inhibitors of cIAP-1/2 and XIAP proteins.Therapeutic potential and molecular mechanism of a novel, potent, nonpeptide, Smac mimetic SM-164 in combination with TRAIL for cancer treatmentPotent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity.Potent and selective small-molecule inhibitors of cIAP1/2 proteins reveal that the binding of Smac mimetics to XIAP BIR3 is not required for their effective induction of cell death in tumor cells.Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study.Lipid-conjugated Smac analogues.A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.Apoptotic pathways in pancreatic ductal adenocarcinomaOvercoming resistance to TRAIL-induced apoptosis in solid tumor cells by simultaneously targeting death receptors, c-FLIP and IAPs.Design, synthesis, and evaluation of tricyclic, conformationally constrained small-molecule mimetics of second mitochondria-derived activator of caspases.IAPs: what's in a name?Potent, orally bioavailable diazabicyclic small-molecule mimetics of second mitochondria-derived activator of caspases.A potent bivalent Smac mimetic (SM-1200) achieving rapid, complete, and durable tumor regression in mice.Oral Debio1143 (AT406), an antagonist of inhibitor of apoptosis proteins, combined with daunorubicin and cytarabine in patients with poor-risk acute myeloid leukemia--results of a phase I dose-escalation study.Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer.SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.Design, synthesis, and evaluation of potent, nonpeptidic mimetics of second mitochondria-derived activator of caspases.Apoptosis: why and how does it occur in biology?Diagnostic value of selected markers and apoptotic pathways for pancreatic cancer.Overexpression of cIAP2 contributes to 5-FU resistance and a poor prognosis in oral squamous cell carcinoma.c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.Validation of SAG/RBX2/ROC2 E3 ubiquitin ligase as an anticancer and radiosensitizing targetSelective IAP inhibition results in sensitization of unstimulated but not CD40-stimulated chronic lymphocytic leukaemia cells to TRAIL-induced apoptosis.
P2860
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P2860
Inhibitor of apoptosis proteins as targets for anticancer therapy.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Inhibitor of apoptosis proteins as targets for anticancer therapy.
@en
type
label
Inhibitor of apoptosis proteins as targets for anticancer therapy.
@en
prefLabel
Inhibitor of apoptosis proteins as targets for anticancer therapy.
@en
P2860
P1476
Inhibitor of apoptosis proteins as targets for anticancer therapy.
@en
P2860
P304
P356
10.1586/14737140.7.9.1255
P50
P577
2007-09-01T00:00:00Z