about
Human cytidine deaminase: a three-dimensional homology model of a tetrameric metallo-enzyme inferred from the crystal structure of a distantly related dimeric homologuePurine nucleosides bearing 1-alkynyl chains as adenosine receptor agonistsIntersubunit interactions in human cytidine deaminaseN(6)-alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A(3) receptor and a starting point for searching A(2B) ligandsGigantism and acromegaly due to Xq26 microduplications and GPR101 mutation.N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptorUnraveling the structure and function of G protein-coupled receptors through NMR spectroscopy.Design and synthesis of new bicyclic diketopiperazines as scaffolds for receptor probes of structurally diverse functionality.Adenosine deaminase: functional implications and different classes of inhibitors.Deaza- and deoxyadenosine derivatives: synthesis and inhibition of animal viruses as human infection models.Molecular recognition at purine and pyrimidine nucleotide (P2) receptors.Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors.Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors.Ligand and structure-based models for the prediction of ligand-receptor affinities and virtual screenings: Development and application to the beta(2)-adrenergic receptorPharmacochemistry of the platelet purinergic receptors.Activation of the P2Y1 receptor induces apoptosis and inhibits proliferation of prostate cancer cells.Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier.Molecular evolution of the transmembrane domains of G protein-coupled receptors.A2B adenosine receptor blockade inhibits growth of prostate cancer cells.Docking-based virtual screening for ligands of G protein-coupled receptors: not only crystal structures but also in silico models.Computational studies to predict or explain G protein coupled receptor polypharmacologyDevelopment of selective high affinity antagonists, agonists, and radioligands for the P2Y1 receptor.Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.In silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor.Delineation of the molecular mechanisms of nucleoside recognition by cytidine deaminase through virtual screening.Molecular recognition at adenine nucleotide (P2) receptors in platelets.Facilitating adverse drug event detection in pharmacovigilance databases using molecular structure similarity: application to rhabdomyolysis.In silico screening for agonists and blockers of the β(2) adrenergic receptor: implications of inactive and activated state structuresStructural aspects of M₃ muscarinic acetylcholine receptor dimer formation and activation4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y6 receptor.Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors.Molecular modeling of the human P2Y2 receptor and design of a selective agonist, 2'-amino-2'-deoxy-2-thiouridine 5'-triphosphate.Virtual screening leads to the discovery of novel non-nucleotide P2Y₁ receptor antagonists.Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.Allosteric "beta-blocker" isolated from a DNA-encoded small molecule libraryAction of nucleosides and nucleotides at 7 transmembrane-spanning receptors.Seven transmembrane-spanning receptors for free fatty acids as therapeutic targets for diabetes mellitus: pharmacological, phylogenetic, and drug discovery aspects.On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor.Atomistic insights into rhodopsin activation from a dynamic modelHuman P2Y(6) receptor: molecular modeling leads to the rational design of a novel agonist based on a unique conformational preference.
P50
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Stefano Costanzi
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Stefano Costanzi
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Stefano Costanzi
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Stefano Costanzi
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Stefano Costanzi
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Stefano Costanzi
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Stefano Costanzi
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Stefano Costanzi
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Stefano Costanzi
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Stefano Costanzi
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prefLabel
Stefano Costanzi
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Stefano Costanzi
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Stefano Costanzi
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Stefano Costanzi
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Stefano Costanzi
@sl
P106
P1153
7004875324
P21
P2456
P31
P496
0000-0003-3183-7332