Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage. - Wikidata - awgldk - TriplyDB

Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage.

Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage.

http://www.wikidata.org/entity/Q36976768

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Exome sequencing identifies a novel missense variant in RRM2B associated with autosomal recessive progressive external ophthalmoplegia Genes and Pathways Involved in Adult Onset Disorders Featuring Muscle Mitochondrial DNA Instability Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options Limited dCTP availability accounts for mitochondrial DNA depletion in mitochondrial neurogastrointestinal encephalomyopathy (MNGIE)The efficiency of homologous recombination and non-homologous end joining systems in repairing double-strand breaks during cell cycle progression Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase Vaccinia virus-encoded ribonucleotide reductase subunits are differentially required for replication and pathogenesis.Pathomechanisms in coenzyme q10-deficient human fibroblasts.Identification and characterization of alternative promoters, transcripts and protein isoforms of zebrafish R2 gene.Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5'-diphosphate Regulation and functional contribution of thymidine kinase 1 in repair of DNA damage Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer Nucleotide excision repair efficiency in quiescent human fibroblasts is modulated by circadian clock In vivo function of the murid herpesvirus-4 ribonucleotide reductase small subunit.Deoxynucleoside salvage facilitates DNA repair during ribonucleotide reductase blockade in human cervical cancers A functional approach reveals a genetic and physical interaction between ribonucleotide reductase and CHK1 in mammalian cells.Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status Singlet Oxygen-Mediated Oxidation during UVA Radiation Alters the Dynamic of Genomic DNA Replication.Ribonucleotide reductase as one important target of [Tris(1,10-phenanthroline)lanthanum(III)] trithiocyanate (KP772).Clofarabine targets the large subunit (α) of human ribonucleotide reductase in live cells by assembly into persistent hexamers Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells RNase H2-initiated ribonucleotide excision repair.Elevated ribonucleotide reductase levels associate with suppressed radiochemotherapy response in human cervical cancers.PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress.Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers.miR-8-3p regulates mitoferrin in the testes of Bactrocera dorsalis to ensure normal spermatogenesis Ribonucleotide reductase expression in cervical cancer: a radiation therapy oncology group translational science analysis Inhibition of DNA synthesis facilitates expansion of low-complexity repeats: is strand slippage stimulated by transient local depletion of specific dNTPs?A heterozygous truncating mutation in RRM2B causes autosomal-dominant progressive external ophthalmoplegia with multiple mtDNA deletions.Activity of ribonucleotide reductase helps determine how cells repair DNA double strand breaks.Bcl2 induces DNA replication stress by inhibiting ribonucleotide reductase Trafficking of intracellular folates.Targeting ribonucleotide reductase for cancer therapy.Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.Deoxyribonucleotide metabolism, mutagenesis and cancer.Mitochondrial purine and pyrimidine metabolism and beyond.A Critical Balance: dNTPs and the Maintenance of Genome Stability Synthesis of mitochondrial DNA precursors during myogenesis, an analysis in purified C2C12 myotubes.Sensitizing cancer cells: is it really all about U?Essential role of Tip60-dependent recruitment of ribonucleotide reductase at DNA damage sites in DNA repair during G1 phase.

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Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage.

http://www.wikidata.org/entity/Q36976768

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Proceedings of the National Academy of Sciences of the United States of America

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Artur Fijolek

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Chiara Rampazzo

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Giovanna Pontarin

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Lars Thelander

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Paola Ferraro

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Peter A Reichard

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Tullio Pozzan

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Vera Bianchi

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P2860

Structural basis for the specificity of bipartite nuclear localization sequence binding by importin-alpha

Control of ribonucleotide reductase localization through an anchoring mechanism involving Wtm1.

Nuclear localization of the Saccharomyces cerevisiae ribonucleotide reductase small subunit requires a karyopherin and a WD40 repeat protein.

Subcellular localization of yeast ribonucleotide reductase regulated by the DNA replication and damage checkpoint pathways

A ribonucleotide reductase gene is a transcriptional target of p53 and p73

A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits

p53R2-dependent pathway for DNA synthesis in a p53-regulated cell cycle checkpoint

Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells

Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion

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105

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