Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells
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Overexpression of RRM2 decreases thrombspondin-1 and increases VEGF production in human cancer cells in vitro and in vivo: implication of RRM2 in angiogenesisCobalt substitution of mouse R2 ribonucleotide reductase as a model for the reactive diferrous state: spectroscopic and structural evidence for a ferromagnetically coupled dinuclear cobalt cluster2.6 Å X-ray Crystal Structure of Human p53R2, a p53-Inducible Ribonucleotide Reductase,The crystal structure of human GLRX5: iron-sulfur cluster co-ordination, tetrameric assembly and monomer activityMouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysisMolecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductaseA novel clade of unique eukaryotic ribonucleotide reductase R2 subunits is exclusive to apicomplexan parasitesVaccinia virus-encoded ribonucleotide reductase subunits are differentially required for replication and pathogenesis.Modulating radiation resistance by inhibiting ribonucleotide reductase in cancers with virally or mutationally silenced p53 proteinPhase I trial of pelvic radiation, weekly cisplatin, and 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) for locally advanced cervical cancer.Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5'-diphosphateRegulation and functional contribution of thymidine kinase 1 in repair of DNA damageRedox control systems in the nucleus: mechanisms and functions.Stable suppression of the R2 subunit of ribonucleotide reductase by R2-targeted short interference RNA sensitizes p53(-/-) HCT-116 colon cancer cells to DNA-damaging agents and ribonucleotide reductase inhibitors.Studies of ribonucleotide reductase in crucian carp-an oxygen dependent enzyme in an anoxia tolerant vertebrate.Ribonucleotide reductase is not limiting for mitochondrial DNA copy number in mice.The contribution of mitochondrial thymidylate synthesis in preventing the nuclear genome stressp53R2 inhibits the proliferation of human cancer cells in association with cell-cycle arrest.Structural basis on the dityrosyl-diiron radical cluster and the functional differences of human ribonucleotide reductase small subunits hp53R2 and hRRM2.Papillomaviruses use recombination-dependent replication to vegetatively amplify their genomes in differentiated cellsA functional approach reveals a genetic and physical interaction between ribonucleotide reductase and CHK1 in mammalian cells.A phase I and pharmacokinetic study of oral 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in the treatment of advanced-stage solid cancers: a California Cancer Consortium Study.Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia.Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasisEnhanced subunit interactions with gemcitabine-5'-diphosphate inhibit ribonucleotide reductases.Ribonucleotide reductase inhibitors: a new look at an old target for radiosensitization.Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophages.Development of human cell biosensor system for genotoxicity detection based on DNA damage-induced gene expression.p53R2 expression as a prognostic biomarker in early stage non-small cell lung cancerMEK2 regulates ribonucleotide reductase activity through functional interaction with ribonucleotide reductase small subunit p53R2.Targeting the Large Subunit of Human Ribonucleotide Reductase for Cancer Chemotherapy.RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence.PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress.Expression of thymidylate synthase in human cells is an early G(1) event regulated by CDK4 and p16INK4A but not E2F.Ribonucleotide reduction is a cytosolic process in mammalian cells independently of DNA damage.A heterozygous truncating mutation in RRM2B causes autosomal-dominant progressive external ophthalmoplegia with multiple mtDNA deletions.Activity of ribonucleotide reductase helps determine how cells repair DNA double strand breaks.Targeting ribonucleotide reductase for cancer therapy.Ribonucleotide reductase and cancer: biological mechanisms and targeted therapies.Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells.
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P2860
Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells
description
2001 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im November 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 2 November 2001)
@en
vedecký článok (publikovaný 2001/11/02)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/11/02)
@nl
наукова стаття, опублікована в листопаді 2001
@uk
name
Mammalian p53R2 protein forms ...... age and in proliferating cells
@ast
Mammalian p53R2 protein forms ...... age and in proliferating cells
@en
Mammalian p53R2 protein forms ...... age and in proliferating cells
@nl
type
label
Mammalian p53R2 protein forms ...... age and in proliferating cells
@ast
Mammalian p53R2 protein forms ...... age and in proliferating cells
@en
Mammalian p53R2 protein forms ...... age and in proliferating cells
@nl
prefLabel
Mammalian p53R2 protein forms ...... age and in proliferating cells
@ast
Mammalian p53R2 protein forms ...... age and in proliferating cells
@en
Mammalian p53R2 protein forms ...... age and in proliferating cells
@nl
P2093
P2860
P50
P356
P1476
Mammalian p53R2 protein forms ...... age and in proliferating cells
@en
P2093
L Thelander
N Voevodskaya
Y Nakamura
P2860
P304
P356
10.1074/JBC.M106088200
P407
P577
2001-11-02T00:00:00Z