Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.
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Neonatal diabetes: an expanding list of genes allows for improved diagnosis and treatmentSystemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of RodentsPharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channelsNeonatal diabetes mellitus: a model for personalized medicineReversible changes in pancreatic islet structure and function produced by elevated blood glucose.The use of animal models in diabetes research.Modeling K,ATP--dependent excitability in pancreatic islets.Overexpression of Fto leads to increased food intake and results in obesityNicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.The cost-effectiveness of personalized genetic medicine: the case of genetic testing in neonatal diabetes.Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetesMuscle KATP channels: recent insights to energy sensing and myoprotectionAcute sulfonylurea therapy at disease onset can cause permanent remission of KATP-induced diabetes.Successful sulfonylurea treatment of an insulin-naïve neonate with diabetes mellitus due to a KCNJ11 mutationHyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in miceMice expressing a human K(ATP) channel mutation have altered channel ATP sensitivity but no cardiac abnormalities.Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and NoiseGLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.Accounting for near-normal glucose sensitivity in Kir6.2[AAA] transgenic mice.Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells.Diabetes induced by gain-of-function mutations in the Kir6.1 subunit of the KATP channel.Molecular biology of K(ATP) channels and implications for health and disease.Mutations in KCNJ11 are associated with the development of autosomal dominant, early-onset type 2 diabetes.Decreasing cx36 gap junction coupling compensates for overactive KATP channels to restore insulin secretion and prevent hyperglycemia in a mouse model of neonatal diabetes.The role of the KATP channel in glucose homeostasis in health and disease: more than meets the islet.Current understanding of K ATP channels in neonatal diseases: focus on insulin secretion disorders.Diabetes mellitus and the β cell: the last ten years.The diabetic β-cell: hyperstimulated vs. hyperexcited.K(ATP) channels and islet hormone secretion: new insights and controversies.β-Cell dysfunction in diabetes: a crisis of identity?Pancreatic β-cell identity in diabetes.Sulfonylurea challenge test in subjects diagnosed with type 1 diabetes mellitus.Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes.Interaction between mutations in the slide helix of Kir6.2 associated with neonatal diabetes and neurological symptoms.Defects in beta cell Ca²+ signalling, glucose metabolism and insulin secretion in a murine model of K(ATP) channel-induced neonatal diabetes mellitusPancreatic β cell dedifferentiation in diabetes and redifferentiation following insulin therapy.A mutation causing increased KATP channel activity leads to reduced anxiety in mice.Molecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.Mouse models and the interpretation of human GWAS in type 2 diabetes and obesity.
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Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 December 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Expression of an activating mu ...... capitulates neonatal diabetes.
@en
Expression of an activating mu ...... capitulates neonatal diabetes.
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type
label
Expression of an activating mu ...... capitulates neonatal diabetes.
@en
Expression of an activating mu ...... capitulates neonatal diabetes.
@nl
prefLabel
Expression of an activating mu ...... capitulates neonatal diabetes.
@en
Expression of an activating mu ...... capitulates neonatal diabetes.
@nl
P2093
P2860
P50
P356
P1476
Expression of an activating mu ...... capitulates neonatal diabetes.
@en
P2093
Alison Hugill
Anne Clark
Chris Church
Christophe A Girard
F Thomas Wunderlich
Fernando Abdulkader
Frances M Ashcroft
Juris Galvanovskis
Kenju Shimomura
Lejla Zubcevic
P2860
P356
10.1172/JCI35772
P407
P577
2008-12-08T00:00:00Z