Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination.
about
Functional anatomy of the immunoglobulin heavy chain 3΄ super-enhancer needs not only core enhancer elements but also their unique DNA contextRegulating infidelity: RNA-mediated recruitment of AID to DNA during class switch recombinationRNA Exosome and Non-coding RNA-Coupled Mechanisms in AID-Mediated Genomic Alterations.Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression.EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loopGenerating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination.Unequal opportunity during class switching
P2860
Q33741094-EAF55C37-C63C-4C66-A954-BD17C7D40441Q37730047-2E897130-09EC-4911-8E8A-4207CD898886Q39077274-36CF576B-7927-4F89-901E-61C997F60D45Q40587292-9B6526F7-C2CE-43DC-828A-0CEC65CC260BQ42376080-48D57796-0E15-4D7E-B373-7B900B63EFDFQ55092495-B3F1A99C-C9CC-4710-AC44-6CBAB4BBB234Q74441764-D3743867-EC47-4468-AA25-E01291C25C62
P2860
Efficient AID targeting of switch regions is not sufficient for optimal class switch recombination.
description
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name
Efficient AID targeting of swi ...... al class switch recombination.
@en
Efficient AID targeting of swi ...... al class switch recombination.
@nl
type
label
Efficient AID targeting of swi ...... al class switch recombination.
@en
Efficient AID targeting of swi ...... al class switch recombination.
@nl
prefLabel
Efficient AID targeting of swi ...... al class switch recombination.
@en
Efficient AID targeting of swi ...... al class switch recombination.
@nl
P2860
P50
P356
P1476
Efficient AID targeting of swi ...... mal class switch recombination
@en
P2093
Fabien Lechouane
P2860
P2888
P356
10.1038/NCOMMS8613
P407
P577
2015-07-06T00:00:00Z