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The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescenceMultiple facets of p53 in senescence induction and maintenanceConnecting the Dots: From DNA Damage and Repair to AgingProtein degradation and the stress responseThe impact of cellular senescence in cancer therapy: is it true or not?Murine models and cell lines for the investigation of pheochromocytoma: applications for future therapies?The FHIT gene product: tumor suppressor and genome "caretaker"Disruptive chemicals, senescence and immortalityTherapeutic targeting of replicative immortalityElucidating distinct roles for NF1 in melanomagenesisRedox control of senescence and age-related diseaseSnoN functions as a tumour suppressor by inducing premature senescenceQuantitation and Identification of Thousands of Human Proteoforms below 30 kDaWidespread genomic instability mediated by a pathway involving glycoprotein Ib alpha and Aurora B kinase.Cellular senescence in livers from children with end stage liver diseaseJnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model.PPARβ/δ promotes HRAS-induced senescence and tumor suppression by potentiating p-ERK and repressing p-AKT signalingMinireview: physiological and pathological actions of RAS in the ovary.Changed genome heterochromatinization upon prolonged activation of the Raf/ERK signaling pathway.HiJAK'd Signaling; the STAT3 Paradox in Senescence and Cancer Progression.Growth arrest signaling of the Raf/MEK/ERK pathway in cancer.Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescenceThe nuclear receptor peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) promotes oncogene-induced cellular senescence through repression of endoplasmic reticulum stress.Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cellsInsulin-like growth factor-1 regulates the SIRT1-p53 pathway in cellular senescence.Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis.Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.The histone demethylase Jarid1b (Kdm5b) is a novel component of the Rb pathway and associates with E2f-target genes in MEFs during senescence.MSK1 triggers the expression of the INK4AB/ARF locus in oncogene-induced senescence.Molecular genetics of prostate cancer: new prospects for old challengesCooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivoComplete deletion of Apc results in severe polyposis in mice.ERK and JNK activation is essential for oncogenic transformation by v-Rel.Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescenceIrreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.E2f binding-deficient Rb1 protein suppresses prostate tumor progression in vivoA kinase shRNA screen links LATS2 and the pRB tumor suppressorPKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors.p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype.TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells.
P2860
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P2860
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 14 January 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Many roads lead to oncogene-induced senescence.
@en
Many roads lead to oncogene-induced senescence.
@nl
type
label
Many roads lead to oncogene-induced senescence.
@en
Many roads lead to oncogene-induced senescence.
@nl
prefLabel
Many roads lead to oncogene-induced senescence.
@en
Many roads lead to oncogene-induced senescence.
@nl
P2093
P2860
P356
P1433
P1476
Many roads lead to oncogene-induced senescence.
@en
P2093
K Cichowski
S Courtois-Cox
P2860
P2888
P304
P356
10.1038/SJ.ONC.1210950
P407
P577
2008-01-14T00:00:00Z