Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts. - Wikidata - awgldk - TriplyDB

Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

http://www.wikidata.org/entity/Q37109228

about

Effect of magnolol on the function of osteoblastic MC3T3-E1 cells Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor α action in osteoblast differentiation Bone density, structure, and strength in juvenile idiopathic arthritis: importance of disease severity and muscle deficits CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation The Role of Bone Marrow Microenvironment in Governing the Balance between Osteoblastogenesis and Adipogenesis RUNX2 and the PI3K/AKT axis reciprocal activation as a driving force for tumor progression Effects of anti-tumor necrosis factor α agents on bone The alliance of mesenchymal stem cells, bone, and diabetes MicroRNA-208 modulates BMP-2-stimulated mouse preosteoblast differentiation by directly targeting V-ets erythroblastosis virus E26 oncogene homolog 1 Altered bone remodeling in psoriatic arthritis Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells Role of TNF alpha and PLF in bone remodeling in a rat model of repetitive reaching and grasping Prolonged performance of a high repetition low force task induces bone adaptation in young adult rats, but loss in mature rats.The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation Lipopolysaccharide-induced epithelial monoamine oxidase mediates alveolar bone loss in a rat chronic wound model The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpoint The synovio-entheseal complex in enthesoarthritis.Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation.NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-κB.Msx2 mediates the inhibitory action of TNF-alpha on osteoblast differentiation.Glucocorticoid-induced leucine zipper (GILZ) antagonizes TNF-α inhibition of mesenchymal stem cell osteogenic differentiation.Wnt10b activates the Wnt, notch, and NFκB pathways in U2OS osteosarcoma cells.Novel functions for NFκB: inhibition of bone formation Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection TNFalpha mediates the skeletal effects of thyroid-stimulating hormone Ubiquitin-dependent regulation of TGFbeta signaling in cancer Smurf1 inhibits mesenchymal stem cell proliferation and differentiation into osteoblasts through JunB degradation.High-fat diet causes bone loss in young mice by promoting osteoclastogenesis through alteration of the bone marrow environment.Impact of targeted PPARγ disruption on bone remodeling.TNF Induction of NF-κB RelB Enhances RANKL-Induced Osteoclastogenesis by Promoting Inflammatory Macrophage Differentiation but also Limits It through Suppression of NFATc1 Expression Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation.Cyclic AMP Response Element-binding Protein H (CREBH) Mediates the Inhibitory Actions of Tumor Necrosis Factor α in Osteoblast Differentiation by Stimulating Smad1 Degradation.Signaling networks that control the lineage commitment and differentiation of bone cells.Modulation of TGF-beta signaling by proinflammatory cytokines in articular chondrocytes.MiR-690, a Runx2-targeted miRNA, regulates osteogenic differentiation of C2C12 myogenic progenitor cells by targeting NF-kappaB p65.Signaling and transcriptional regulation in osteoblast commitment and differentiation Smurf2 regulates the senescence response and suppresses tumorigenesis in mice.Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148.Ubiquitin ligase Smurf1 mediates tumor necrosis factor-induced systemic bone loss by promoting proteasomal degradation of bone morphogenetic signaling proteins.NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation.

P2860

Q21284960-87A4F56A-A118-494A-8CAF-E63BA09D959A Q24635851-53FB9ED0-3131-4DF3-979A-98A78E966D7A Q24653333-AF9F4116-8A4F-45F8-830C-031D9E209402 Q24656900-F95DE10D-5467-4E94-A876-59E5E95C8FBD Q26738893-B8EB04FD-39E2-4D84-9840-2C3914846642 Q26800112-21325ABE-8EC5-472B-B565-FEABE79D6BEC Q26851274-FFFFBCF5-5D87-478F-B65C-CFB5C9C477CC Q27012497-61ACAFA4-C0A2-4064-8413-004836300ACC Q28115930-B7C38892-B760-492D-88C4-F0075FE8A806 Q28288855-E6FDB78C-4F19-48C0-ABCD-9B215D323BB4 Q28297767-32E12F05-95CF-4FBC-B27B-19F2C2E6B3DD Q28384638-9EBF03A8-9BF4-4F89-A7B3-529DE4CE6781 Q28394469-C752F1E5-4EB8-4846-A1ED-B35263E1631F Q28511737-A94593BB-9298-4D7D-B8CD-187330248463 Q28578321-2068E1A5-59F8-4F9C-A4F6-FD8B0B6E4F9A Q30484127-25B91D1A-897E-446D-A77D-78EF8C4989F1 Q33360030-D578AB02-2A9A-4979-9775-79C26CA2BD82 Q33645449-C8427B11-676E-495B-8DA6-878CE419E763 Q33808220-6FF82854-3FC8-46B9-980A-3081E7F841F5 Q33942820-166E01EC-88C2-44B4-8FA0-20B1533F2517 Q34187108-E9B1127C-6115-47B0-91B7-E29A81D801FD Q34765411-9458349C-1109-49B9-AFBA-DD8EDBA57DD0 Q34806538-D0C1C0C6-1E3B-433D-BFBE-F21E82AD4B5F Q34947708-E9EAD16A-5B89-47C8-BE7C-B8053CFBE067 Q35036487-0BA22FEF-61AD-4D4D-ABCB-39E777E54EF6 Q35082727-9D15627F-52AB-4EBF-B6B7-30B2D40890AC Q35155505-9844DEF2-96B5-47E0-8018-122B3B25193A Q35247362-20A8CE68-F8C7-4B03-AA7E-20DD06DC916F Q35648762-1833DD07-9FB3-4C96-9068-B700FA177ECE Q35750113-264928BF-2E4B-4EBE-97ED-4A0493FB1B45 Q35769073-2B4AB430-3BBE-4213-9623-90C9F508B289 Q35861035-49927B0A-A154-4152-AB90-B97487DF6427 Q36082866-C524B71F-2353-4DCE-B4EE-138F4ECFFF45 Q36298185-10B3EAA5-4244-48D8-B9EE-D35EE5568D85 Q36574817-12B92B3D-2116-4B3F-9BA7-E85413446CF4 Q36606452-E0DB9EC4-539E-4741-AE0D-A1FCE3676C67 Q36740590-04DAE51C-E7A6-43F3-8980-93F0A2CA6675 Q36784318-0053CA85-9282-4BC2-A875-D95C4860D95E Q36838785-FD289DDD-4E24-4BAD-965A-9F4EB5CE761E Q36915352-06237787-01BB-4C87-AB14-6D712C7FD03B

P2860

Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts.

http://www.wikidata.org/entity/Q37109228

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 22 December 2005

@en

vedecký článok

@sk

vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Tumor necrosis factor promotes ...... rf1 and Smurf2 in osteoblasts.

@en

Tumor necrosis factor promotes ...... rf1 and Smurf2 in osteoblasts.

@nl

type

label

Tumor necrosis factor promotes ...... rf1 and Smurf2 in osteoblasts.

@en

Tumor necrosis factor promotes ...... rf1 and Smurf2 in osteoblasts.

@nl

prefLabel

Tumor necrosis factor promotes ...... rf1 and Smurf2 in osteoblasts.

@en

Tumor necrosis factor promotes ...... rf1 and Smurf2 in osteoblasts.

@nl

P1433

Q37109228-A82210BC-8328-4B96-AA85-CED5028D9D54

P1476

Q37109228-844E0599-8B9E-4204-AC88-716B2BBF2507

P2093

Q37109228-24D4F57A-FE25-4940-8118-E54B104C1C3B

Q37109228-5C2921E1-8ED8-4F69-95DA-98C921C615DF

Q37109228-887ACB7D-8A4D-4566-9834-28B0ECAA323F

Q37109228-8D42CE07-574F-4DBE-9C1B-1882D71F2069

Q37109228-D00A18CD-8165-48B8-89FA-19BAF24B0BA8

Q37109228-D5200B72-C523-4F00-9C0B-6E7A6383B9B0

Q37109228-F45EB416-2D75-4A78-97D8-560B6DA14497

P2860

Q37109228-03BCD772-7499-4254-A72D-AADA0F101530

Q37109228-055E8022-1461-412A-B815-EF89836E4F95

Q37109228-0AEF235C-3EF7-4B49-BB2F-0E820D354943

Q37109228-13FA58FB-61C7-4AED-A694-0D2449BD3ECC

Q37109228-15C849EE-DFAD-4CBF-BB76-1887ACD09B01

Q37109228-197221F1-4426-43D2-AA94-177A521A2400

Q37109228-1C534797-CCCF-46AF-954B-532BAC80EF52

Q37109228-28F26CB9-9B2D-4749-B853-49224CE91311

Q37109228-373650A4-67D3-4254-AEF5-E60BC11C7250

Q37109228-44037435-95A1-441C-BF99-0EE8C8087A40

P304

Q37109228-E4B38746-023C-45C2-AEE7-ADA006C79308

P31

Q37109228-0EAF80F6-6A39-4265-AE4A-F9970034FF58

P356

Q37109228-F2361772-2FE9-42F6-9EEF-7D1B9DA63206

P407

Q37109228-A33E8547-96BF-45CC-A36C-75F6C3FF0AD1

P433

Q37109228-72BF7DEA-82C0-42DA-BE92-7D1DC48D388B

P478

Q37109228-E9784ABC-18EB-4945-8518-9B37B776361A

P50

Q37109228-818DDAC4-288E-43C6-9C07-D70274B98F53

P577

Q37109228-6C7D46D7-801F-4867-BBC7-14814E5454FC

P698

Q37109228-21BADE2E-1425-495C-864D-5AB4518FDA28

P921

Q37109228-BC40182A-98AB-43AF-8693-0A376F2AB156

P932

Q37109228-10FACBFB-3FB6-4B58-82BD-CD971365522E

P356

P1433

Journal of Biological Chemistry

P1476

Tumor necrosis factor promotes ...... urf1 and Smurf2 in osteoblasts

@en

P2093

Brendan F Boyce

http://www.w3.org/2001/XMLSchema#string

Di Chen

http://www.w3.org/2001/XMLSchema#string

Edward M Schwarz

http://www.w3.org/2001/XMLSchema#string

Hiroyuki Kaneki

http://www.w3.org/2001/XMLSchema#string

Lianping Xing

http://www.w3.org/2001/XMLSchema#string

Ruolin Guo

http://www.w3.org/2001/XMLSchema#string

Zhenqiang Yao

http://www.w3.org/2001/XMLSchema#string

P2860

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Stress-induced decrease in TRAF2 stability is mediated by Siah2

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis

Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

Identification of ubiquitin ligases required for skeletal muscle atrophy

Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal muscle after LPS injection

P304

4326-4333

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M509430200

http://www.w3.org/2001/XMLSchema#string

P407

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

281

http://www.w3.org/2001/XMLSchema#string

P50

P577

2005-12-22T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

16373342

http://www.w3.org/2001/XMLSchema#string

P921

P932

2647592

http://www.w3.org/2001/XMLSchema#string