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ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repressionMEIS1-mediated transactivation of synaptotagmin-like 1 promotes CXCL12/CXCR4 signaling and leukemogenesis.Importance of a specific amino acid pairing for murine MLL leukemias driven by MLLT1/3 or AFF1/4Tgif1 regulates quiescence and self-renewal of hematopoietic stem cellsHigh expression of IGFBP2 is associated with chemoresistance in adult acute myeloid leukemiaLikelihood-Based Approach to Gene Set Enrichment Analysis with a Finite Mixture ModelSelective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.Down-regulation of homeobox genes MEIS1 and HOXA in MLL-rearranged acute leukemia impairs engraftment and reduces proliferationTwo decades of leukemia oncoprotein epistasis: the MLL1 paradigm for epigenetic deregulation in leukemia.Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells.PU.1 is essential for MLL leukemia partially via crosstalk with the MEIS/HOX pathway.MLL fusions: pathways to leukemiaPU.1 affects proliferation of the human acute myeloid leukemia U937 cell line by directly regulating MEIS1.CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements.EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.MiR-495 is a tumor-suppressor microRNA down-regulated in MLL-rearranged leukemia.miR-196b directly targets both HOXA9/MEIS1 oncogenes and FAS tumour suppressor in MLL-rearranged leukaemia.PBX3 is an important cofactor of HOXA9 in leukemogenesis.Identification of MLL-fusion/MYC⊣miR-26⊣TET1 signaling circuit in MLL-rearranged leukemia.PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the MLL-Rearranged DiseasePbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors.TET1 plays an essential oncogenic role in MLL-rearranged leukemiap27kip1 maintains a subset of leukemia stem cells in the quiescent state in murine MLL-leukemia.MLL-Rearranged Leukemias-An Update on Science and Clinical Approaches.Promoter variants in the MSMB gene associated with prostate cancer regulate MSMB/NCOA4 fusion transcriptsmicroRNA regulation in megakaryocytopoiesis.Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis.HOXB13 mutations and binding partners in prostate development and cancer: Function, clinical significance, and future directionsAn ShRNA Screen Identifies MEIS1 as a Driver of Malignant Peripheral Nerve Sheath Tumors.Hif-1α and Hif-2α synergize to suppress AML development but are dispensable for disease maintenanceMLL-AF9 and MLL-AF4 oncofusion proteins bind a distinct enhancer repertoire and target the RUNX1 program in 11q23 acute myeloid leukemia.MEIS1, PREP1, and PBX4 are differentially expressed in acute lymphoblastic leukemia: association of MEIS1 expression with higher proliferation and chemotherapy resistance.Meis1 is critical to the maintenance of human acute myeloid leukemia cells independent of MLL rearrangements.Correlation Between Meis1 and Msi1 in Esophageal Squamous Cell Carcinoma.t(4;11) leukemias display addiction to MLL-AF4 but not to AF4-MLLGene mutational pattern and expression level in 560 acute myeloid leukemia patients and their clinical relevance.TGIF1 is a negative regulator of MLL-rearranged acute myeloid leukemia.MEIS1 regulates early erythroid and megakaryocytic cell fate.Regulation of MEIS1 by distal enhancer elements in acute leukemia.
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description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 24 December 2008
@en
vedecký článok
@sk
vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A role for MEIS1 in MLL-fusion gene leukemia
@en
A role for MEIS1 in MLL-fusion gene leukemia.
@nl
type
label
A role for MEIS1 in MLL-fusion gene leukemia
@en
A role for MEIS1 in MLL-fusion gene leukemia.
@nl
prefLabel
A role for MEIS1 in MLL-fusion gene leukemia
@en
A role for MEIS1 in MLL-fusion gene leukemia.
@nl
P2093
P2860
P1433
P1476
A role for MEIS1 in MLL-fusion gene leukemia
@en
P2093
Ashish R Kumar
Branden J Kowal
Erik A Lund
John H Kersey
Quanzhi Li
Weili Chen
Wendy A Hudson
P2860
P304
P356
10.1182/BLOOD-2008-06-163287
P407
P50
P577
2008-12-24T00:00:00Z