Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling.
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Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairmentsEnlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2.Two knockdown models of the autism genes SYNGAP1 and SHANK3 in zebrafish produce similar behavioral phenotypes associated with embryonic disruptions of brain morphogenesis.Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B(-/-) miceDysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice.Actin-Dependent Alterations of Dendritic Spine Morphology in ShankopathiesMolecular handoffs in nitrergic neurotransmissionBreaking down to build up: Neuroligin's C-terminal domain strengthens the synapse.Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of AutismAn urgent need for experimental animal model of autism in drug development.Absence of strong strain effects in behavioral analyses of Shank3-deficient miceLoss of predominant Shank3 isoforms results in hippocampus-dependent impairments in behavior and synaptic transmission.Studying autism in rodent models: reconciling endophenotypes with comorbiditiesShank3-mutant mice lacking exon 9 show altered excitation/inhibition balance, enhanced rearing, and spatial memory deficit.Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID.Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activationThe spectrum of epilepsy and electroencephalographic abnormalities due to SHANK3 loss-of-function mutationsThe Shank3 Interaction Partner ProSAPiP1 Regulates Postsynaptic SPAR Levels and the Maturation of Dendritic Spines in Hippocampal Neurons.Neurexins.Intellectual disability and autism spectrum disorders: causal genes and molecular mechanisms.Proceedings of the 2013 annual meeting of the Fetal Alcohol Spectrum Disorders Study Group.Altered network topologies and hub organization in adults with autism: a resting-state fMRI studyPresynaptic active zones in invertebrates and vertebrates.Rare variants in the neurotrophin signaling pathway implicated in schizophrenia risk.Environmental factors in autism.Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links.Shank3 Is Part of a Zinc-Sensitive Signaling System That Regulates Excitatory Synaptic Strength.Genome-wide association study of autistic-like traits in a general population study of young adults.Shank mutant mice as an animal model of autism.Parkin Deficiency Reduces Hippocampal Glutamatergic Neurotransmission by Impairing AMPA Receptor Endocytosis.The role of ionotropic glutamate receptors in childhood neurodevelopmental disorders: autism spectrum disorders and fragile x syndrome.A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders.Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches.A blueprint for research on Shankopathies: a view from research on autism spectrum disorder.Heterogeneity and convergence: the synaptic pathophysiology of autism.Phelan McDermid Syndrome: From Genetic Discoveries to Animal Models and Treatment.SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras.N-terminal SAP97 isoforms differentially regulate synaptic structure and postsynaptic surface pools of AMPA receptors.A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.Altered thalamocortical development in the SAP102 knockout model of intellectual disability.
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P2860
Autism-associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin-mediated transsynaptic signaling.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on October 2012
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Autism-associated mutations in ...... iated transsynaptic signaling.
@en
Autism-associated mutations in ...... iated transsynaptic signaling.
@nl
type
label
Autism-associated mutations in ...... iated transsynaptic signaling.
@en
Autism-associated mutations in ...... iated transsynaptic signaling.
@nl
prefLabel
Autism-associated mutations in ...... iated transsynaptic signaling.
@en
Autism-associated mutations in ...... iated transsynaptic signaling.
@nl
P2093
P2860
P1476
Autism-associated mutations in ...... diated transsynaptic signaling
@en
P2093
Charlotte J Thynne
Craig C Garner
Johanna M Montgomery
Magali H Arons
Michael Schoen
Tobias M Boeckers
P2860
P304
14966-14978
P356
10.1523/JNEUROSCI.2215-12.2012
P407
P577
2012-10-01T00:00:00Z