The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication.
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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancerPolo-like kinase 4: the odd one out of the familyA cryptic TOG domain with a distinct architecture underlies CLASP-dependent bipolar spindle formationCep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosomePLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycleGenomic screening with RNAi: results and challengesp53 protects against genome instability following centriole duplication failureCentrosome/Cell cycle uncoupling and elimination in the endoreduplicating intestinal cells of C. elegansThe Structure of the Plk4 Cryptic Polo Box Reveals Two Tandem Polo Boxes Required for Centriole DuplicationThe PLK4-STIL-SAS-6 module at the core of centriole duplicationMDM1 is a microtubule-binding protein that negatively regulates centriole duplicationA mechanism for the elimination of the female gamete centrosome in Drosophila melanogasterDrosophila casein kinase I alpha regulates homolog pairing and genome organization by modulating condensin II subunit Cap-H2 levelsSubdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organization.Control of mitotic and meiotic centriole duplication by the Plk4-related kinase ZYG-1Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesisDisruption of clathrin-mediated trafficking causes centrosome overduplication and senescence.Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification.DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6.Polo-like kinase 4 kinase activity limits centrosome overduplication by autoregulating its own stability.The Centrioles, Centrosomes, Basal Bodies, and Cilia of Drosophila melanogaster.Autophosphorylation of polo-like kinase 4 and its role in centriole duplicationPrecocious centriole disengagement and centrosome fragmentation induced by mitotic delayCDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes.E2F activators signal and maintain centrosome amplification in breast cancer cells.Centrioles: active players or passengers during mitosis?The centriole duplication cycle.Causes and consequences of centrosome abnormalities in cancer.Centrosome biogenesis continues in the absence of microtubules during prolonged S-phase arrest.Centriole duplication: analogue control in a digital ageDefining components of the ß-catenin destruction complex and exploring its regulation and mechanisms of action during developmentDo candidate genes mediating conspecific sperm precedence affect sperm competitive ability within species? A test case in Drosophila.The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries.Cep152 interacts with Plk4 and is required for centriole duplication.SmSak, the second Polo-like kinase of the helminth parasite Schistosoma mansoni: conserved and unexpected roles in meiosisThe F-box protein Slmb restricts the activity of aPKC to polarize epithelial cellsPlk4/SAK/ZYG-1 in the regulation of centriole duplication.Direct interaction of Plk4 with STIL ensures formation of a single procentriole per parental centriole.Plk4 phosphorylates Ana2 to trigger Sas6 recruitment and procentriole formation.Centriole duplication: A lesson in self-control.
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The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on January 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The SCF Slimb ubiquitin ligase ...... block centriole reduplication.
@en
The SCF Slimb ubiquitin ligase ...... block centriole reduplication.
@nl
type
label
The SCF Slimb ubiquitin ligase ...... block centriole reduplication.
@en
The SCF Slimb ubiquitin ligase ...... block centriole reduplication.
@nl
prefLabel
The SCF Slimb ubiquitin ligase ...... block centriole reduplication.
@en
The SCF Slimb ubiquitin ligase ...... block centriole reduplication.
@nl
P2093
P2860
P356
P1476
The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication
@en
P2093
David M Roberts
Gregory C Rogers
Nasser M Rusan
Stephen L Rogers
P2860
P304
P356
10.1083/JCB.200808049
P407
P50
P577
2009-01-01T00:00:00Z