Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions. - Wikidata - awgldk - TriplyDB

Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions.

Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions.

http://www.wikidata.org/entity/Q37140009

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Opioid receptors: toward separation of analgesic from undesirable effects Broad-spectrum analgesic efficacy of IBNtxA is mediated by exon 11-associated splice variants of the mu-opioid receptor gene.Mu opioid receptors in pain management.Molecular insights into mu opioid pharmacology: From the clinic to the bench.Opiate pharmacology and relief of pain.Pharmacologic characterization in the rat of a potent analgesic lacking respiratory depression, IBNtxA.Mu-opioid receptor splice variants: sex-dependent regulation by chronic morphine.Truncated G protein-coupled mu opioid receptor MOR-1 splice variants are targets for highly potent opioid analgesics lacking side effects.Differential expressions of the alternatively spliced variant mRNAs of the µ opioid receptor gene, OPRM1, in brain regions of four inbred mouse strains Opioids and their receptors: Are we there yet?Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.Identification and characterization of seven new exon 11-associated splice variants of the rat μ opioid receptor gene, OPRM1.Dysfunctional gene splicing as a potential contributor to neuropsychiatric disorders.Stabilization of morphine tolerance with long-term dosing: association with selective upregulation of mu-opioid receptor splice variant mRNAs.Dopamine, norepinephrine and serotonin transporter gene deletions differentially alter cocaine-induced taste aversion.Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies.Preclinical pharmacology and opioid combinations.mRNA transcript diversity creates new opportunities for pharmacological intervention.Mediation of opioid analgesia by a truncated 6-transmembrane GPCR.Splice variation of the mu-opioid receptor and its effect on the action of opioids.Regulation and Functional Implications of Opioid Receptor Splicing in Opioid Pharmacology and HIV Pathogenesis Attenuated effects of experimenter-administered heroin in adolescent vs. adult male rats: physical withdrawal and locomotor sensitization.Ligand-biased activation of extracellular signal-regulated kinase 1/2 leads to differences in opioid induced antinociception and tolerance.Methadone-induced hypoglycemia.Truncated mu opioid GPCR variant involvement in opioid-dependent and opioid-independent pain modulatory systems within the CNS.Comparison of (+)- and (-)-Naloxone on the Acute Psychomotor-Stimulating Effects of Heroin, 6-Acetylmorphine, and Morphine in Mice.Stabilization of the μ-opioid receptor by truncated single transmembrane splice variants through a chaperone-like action.Levels of heroin and its metabolites in blood and brain extracellular fluid after i.v. heroin administration to freely moving rats.Mu opioids and their receptors: evolution of a concept.Alternative Splicing of G Protein-Coupled Receptors: Relevance to Pain Management.Mice lacking the G protein gamma3-subunit show resistance to opioids and diet induced obesity.Morphine regulates expression of μ-opioid receptor MOR-1A, an intron-retention carboxyl terminal splice variant of the μ-opioid receptor (OPRM1) gene via miR-103/miR-107.Isolating and characterizing three alternatively spliced mu opioid receptor variants: mMOR-1A, mMOR-1O, and mMOR-1P.Alternatively spliced mu opioid receptor C termini impact the diverse actions of morphine.Transcriptional and epigenetic regulation of opioid receptor genes: present and future.Pharmacogenomics of the human µ-opioid receptor.Evidence from basic research for opioid combinations.μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids.A "tail" of opioid receptor variants.Tetrapeptide Endomorphin Analogs Require Both Full Length and Truncated Splice Variants of the Mu Opioid Receptor Gene Oprm1 for Analgesia.

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Involvement of exon 11-associated variants of the mu opioid receptor MOR-1 in heroin, but not morphine, actions.

http://www.wikidata.org/entity/Q37140009

description

article científic

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article scientifique

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bilimsel makale

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scientific article published on 09 March 2009

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vedecký článok

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vetenskaplig artikel

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vědecký článek

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name

Involvement of exon 11-associa ...... in, but not morphine, actions.

@en

Involvement of exon 11-associa ...... in, but not morphine, actions.

@nl

type

label

Involvement of exon 11-associa ...... in, but not morphine, actions.

@en

Involvement of exon 11-associa ...... in, but not morphine, actions.

@nl

prefLabel

Involvement of exon 11-associa ...... in, but not morphine, actions.

@en

Involvement of exon 11-associa ...... in, but not morphine, actions.

@nl

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PNAS.0811586106

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Proceedings of the National Academy of Sciences of the United States of America

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Involvement of exon 11-associa ...... in, but not morphine, actions.

@en

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Gavril W Pasternak

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Grace C Rossi

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Jin Xu

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Joshua E Matulonis

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Mingming Xu

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Ying-Xian Pan

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P2860

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

A comparative study of physiological and subjective effects of heroin and morphine administered intravenously in postaddicts

Identification and characterization of six new alternatively spliced variants of the human mu opioid receptor gene, Oprm

Identification of three new alternatively spliced variants of the rat mu opioid receptor gene: dissociation of affinity and efficacy

Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia

Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene.

Isolation and characterization of new exon 11-associated N-terminal splice variants of the human mu opioid receptor gene.

Classification of multiple morphine and enkephalin binding sites in the central nervous system

Expression of two variants of the human mu opioid receptor mRNA in SK-N-SH cells and human brain.

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene.

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10.1073/PNAS.0811586106

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