Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells.
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The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinomaThe impact of the Cancer Genome Atlas on lung cancer.Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung AdenocarcinomaProtein kinase C iota regulates pancreatic acinar-to-ductal metaplasiap62 binding to protein kinase C ζ regulates tumor necrosis factor α-induced apoptotic pathway in endothelial cellsSplice variants of SmgGDS control small GTPase prenylation and membrane localizationProtein kinase Cι expression and oncogenic signaling mechanisms in cancer.Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer.Meta-analysis of oncogenic protein kinase Ciota signaling in lung adenocarcinoma.Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma.Transcriptomic and metabolomic profiling of ionic liquid stimuli unveils enhanced secondary metabolism in Aspergillus nidulans.The chromosome 3q26 OncCassette: A multigenic driver of human cancer.Insulin signalling in hepatocytes of humans with type 2 diabetes: excessive production and activity of protein kinase C-ι (PKC-ι) and dependent processes and reversal by PKC-ι inhibitors.Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome, and type 2 diabetes mellitus by inhibitors of hepatic protein kinase C-ιProtein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progressionPar complex in cancer: a regulator of normal cell polarity joins the dark side.Protein kinase Cbeta is an effective target for chemoprevention of colon cancer.Atypical protein kinase C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis.Protein kinase C epsilon is involved in ionizing radiation induced bystander response in human cells.PKCι maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis.Phase I dose escalation study of the PKCι inhibitor aurothiomalate for advanced non-small-cell lung cancer, ovarian cancer, and pancreatic cancer.Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC.The aPKCι blocking agent ATM negatively regulates EMT and invasion of hepatocellular carcinoma.Atypical protein kinase Cι as a human oncogene and therapeutic target.Protein kinase C and cancer: what we know and what we do not.The protein kinase C (PKC) inhibitors combined with chemotherapy in the treatment of advanced non-small cell lung cancer: meta-analysis of randomized controlled trials.Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma.A small molecule inhibitor of atypical protein kinase C signaling inhibits pancreatic cancer cell transformed growth and invasion.Atypical protein kinase C phosphorylates Par6 and facilitates transforming growth factor β-induced epithelial-to-mesenchymal transitionRoles of partitioning-defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells.Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesisThe carboxyl-terminal domain of atypical protein kinase Czeta binds to ceramide and regulates junction formation in epithelial cells.PKCζ phosphorylates TRAF2 to protect against intestinal ischemia-reperfusion-induced injury.Par6 is phosphorylated by aPKC to facilitate EMT.Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis.Integrated genomic analysis of clear cell ovarian cancers identified PRKCI as a potential therapeutic target.Systematic assessment of cervical cancer initiation and progression uncovers genetic panels for deep learning-based early diagnosis and proposes novel diagnostic and prognostic biomarkers.Targeting atypical protein kinase C iota reduces viability in glioblastoma stem-like cells via a notch signaling mechanism.Transcriptional Profiling of Host Cell Responses to Virulent Haemophilus parasuis: New Insights into Pathogenesis.Protein Kinase C (PKC) Isozymes and Cancer
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Atypical protein kinase C iota expression and aurothiomalate sensitivity in human lung cancer cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Atypical protein kinase C iota ...... ty in human lung cancer cells.
@en
Atypical protein kinase C iota ...... ty in human lung cancer cells.
@nl
type
label
Atypical protein kinase C iota ...... ty in human lung cancer cells.
@en
Atypical protein kinase C iota ...... ty in human lung cancer cells.
@nl
prefLabel
Atypical protein kinase C iota ...... ty in human lung cancer cells.
@en
Atypical protein kinase C iota ...... ty in human lung cancer cells.
@nl
P2093
P2860
P1433
P1476
Atypical protein kinase C iota ...... ty in human lung cancer cells.
@en
P2093
Alan P Fields
E Aubrey Thompson
Roderick P Regala
P2860
P304
P356
10.1158/0008-5472.CAN-08-0438
P407
P577
2008-07-01T00:00:00Z