Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists.
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CDK Inhibitors Roscovitine and CR8 Trigger Mcl-1 Down-Regulation and Apoptotic Cell Death in Neuroblastoma CellsBET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor ModelsThe combination of BH3-mimetic ABT-737 with the alkylating agent temozolomide induces strong synergistic killing of melanoma cells independent of p53ABT-737 overcomes resistance to immunotoxin-mediated apoptosis and enhances the delivery of pseudomonas exotoxin-based proteins to the cell cytosol.Identification of BIRC6 as a novel intervention target for neuroblastoma therapy.Overexpression of Mcl-1L splice variant is associated with poor prognosis and chemoresistance in oral cancers.The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737Therapeutic targets for neuroblastomas.Miniature short hairpin RNA screens to characterize antiproliferative drugsUpregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation.USP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer.Broad targeting of resistance to apoptosis in cancer.How to target apoptosis signaling pathways for the treatment of pediatric cancersRegulation of Transient Site-specific Copy Gain by MicroRNA.YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context.BH3 response profiles from neuroblastoma mitochondria predict activity of small molecule Bcl-2 family antagonists.High efficacy of the BCL-2 inhibitor ABT199 (venetoclax) in BCL-2 high-expressing neuroblastoma cell lines and xenografts and rational for combination with MCL-1 inhibition.Multiple components of the spliceosome regulate Mcl1 activity in neuroblastoma.Neuroblastoma treatment in the post-genomic era.Biomarkers of therapeutic response to BCL2 antagonists in cancer.Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells.EGFR signaling defines Mcl⁻1 survival dependency in neuroblastoma.MiR-125a/b regulates the activation of cancer stem cells in paclitaxel-resistant colon cancer.Protective effect of plaunotol against doxorubicin-induced renal cell death.Mitochondrial Bcl-2 family dynamics define therapy response and resistance in neuroblastomaThe novel Bcl-2 inhibitor ABT-737 is more effective in hypoxia and is able to reverse hypoxia-induced drug resistance in neuroblastoma cells.Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma.ABT-737, a small molecule Bcl-2/Bcl-xL antagonist, increases antimitotic-mediated apoptosis in human prostate cancer cellsUnderstanding sensitivity to BH3 mimetics: ABT-737 as a case study to foresee the complexities of personalized medicine.Preferential targeting of cancer stem cells in the radiosensitizing effect of ABT-737 on HNSCC.The synergism of MCL1 and glycolysis on pediatric acute lymphoblastic leukemia cell survival and prednisolone resistance.Synergistic cytotoxicity of a prostate cancer-specific immunotoxin in combination with the BH3 mimetic ABT-737.MCL-1 inhibition in cancer treatmentDual BRD4 and AURKA Inhibition Is Synergistic against MYCN-Amplified and Nonamplified Neuroblastoma
P2860
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P2860
Mcl1 downregulation sensitizes neuroblastoma to cytotoxic chemotherapy and small molecule Bcl2-family antagonists.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 08 August 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Mcl1 downregulation sensitizes ...... ecule Bcl2-family antagonists.
@en
Mcl1 downregulation sensitizes ...... ecule Bcl2-family antagonists.
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type
label
Mcl1 downregulation sensitizes ...... ecule Bcl2-family antagonists.
@en
Mcl1 downregulation sensitizes ...... ecule Bcl2-family antagonists.
@nl
prefLabel
Mcl1 downregulation sensitizes ...... ecule Bcl2-family antagonists.
@en
Mcl1 downregulation sensitizes ...... ecule Bcl2-family antagonists.
@nl
P2093
P2860
P356
P1476
Mcl1 downregulation sensitizes ...... lecule Bcl2-family antagonists
@en
P2093
Bella Goyal
Brian J Lestini
Bruce R Pawel
Kelly C Goldsmith
Mark N Fluchel
Michael D Hogarty
Xueyuan Liu
P2860
P304
P356
10.4161/CBT.8.16.8964
P50
P577
2009-08-08T00:00:00Z