HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair
about
Hsp90: A New Player in DNA Repair?Targeting Hsp90 in urothelial carcinomaThe HSP90 inhibitor NVP-AUY922 radiosensitizes by abrogation of homologous recombination resulting in mitotic entry with unresolved DNA damageRadiation microbeams as spatial and temporal probes of subcellular and tissue response.The HSP90 inhibitor ganetespib has chemosensitizer and radiosensitizer activity in colorectal cancer.Lucanthone and its derivative hycanthone inhibit apurinic endonuclease-1 (APE1) by direct protein bindingQuantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response.Small molecule inhibitors of DNA repair nuclease activities of APE1.Development and evaluation of human AP endonuclease inhibitors in melanoma and glioma cell linesThe combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells.Schedule-dependent synergy of histone deacetylase inhibitors with DNA damaging agents in small cell lung cancerDNA damage response and repair: insights into strategies for radiation sensitization of gliomasInduction of Hsp70 in tumor cells treated with inhibitors of the Hsp90 activity: A predictive marker and promising target for radiosensitizationThe novel HSP90 inhibitor AT13387 potentiates radiation effects in squamous cell carcinoma and adenocarcinoma cells.Ganetespib radiosensitization for liver cancer therapyA novel ING2 isoform, ING2b, synergizes with ING2a to prevent cell cycle arrest and apoptosis.Enhanced radiosensitization of human glioma cells by combining inhibition of poly(ADP-ribose) polymerase with inhibition of heat shock protein 90Hsp90 Inhibitor Ganetespib Sensitizes Non-Small Cell Lung Cancer to Radiation but Has Variable Effects with Chemoradiation.Molecular basis for the actions of Hsp90 inhibitors and cancer therapy.The heat shock proteins as targets for radiosensitization and chemosensitization in cancerHyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies.DNA Repair Endonucleases: Physiological Roles and Potential as Drug Targets.Realistic biological approaches for improving thermoradiotherapy.TAS-116, a Novel Hsp90 Inhibitor, Selectively Enhances Radiosensitivity of Human Cancer Cells to X-rays and Carbon Ion Radiation.Evaluation of the radiosensitizing potency of chemotherapeutic agents in prostate cancer cells.Receptor-based virtual screening and biological characterization of human apurinic/apyrimidinic endonuclease (Ape1) inhibitors.Hsp90 inhibitor NVP-AUY922 enhances radiation sensitivity of tumor cell lines under hypoxia.The Hsp90 inhibitor SNX-7081 synergizes with and restores sensitivity to fludarabine in chronic lymphocytic leukemia cells with lesions in the TP53 pathway: a potential treatment strategy for fludarabine refractory disease.Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction.Hsp90 Inhibitors NVP-AUY922 and NVP-BEP800 May Exert a Significant Radiosensitization on Tumor Cells along with a Cell Type-Specific Cytotoxicity.Heat shock proteins and DNA repair mechanisms: an updated overview.Strong antitumor synergy between DNA crosslinking and HSP90 inhibition causes massive premitotic DNA fragmentation in ovarian cancer cells.
P2860
Q26778944-505752EA-966B-4D2C-B85F-5B190FAD8AF7Q27023406-12E9A71A-BE28-40E1-8AA9-11DD719A43F5Q28730558-3464CEC0-B671-4EF6-8B94-04CC39157E1AQ33524659-10C34CD7-57B0-4AFD-AC6B-A8D249FE361EQ33912171-98FA4BFC-B89D-47D6-90C8-92AF817C152EQ34025945-1D496427-B9DB-4CC0-A49E-79E4AB757A81Q34100283-FE21F151-3F6F-470E-959E-448CF208550AQ34208966-6F56145E-783E-4D33-AFF8-D965251FE7C0Q34627873-9117C3E7-7CF4-49B6-8F9A-219B01CF58F4Q35236805-50E08978-A5FB-4784-89E5-E7CAC759FD4DQ35557022-1E59CDCF-934B-4ADA-9F32-3F41553DB60DQ35608458-506884D8-C3B4-46BA-8DB1-7DE21F72AFE9Q36307472-7D721167-67F4-4228-A675-3325C7DB101DQ36546425-2A442264-41EB-4177-999C-8C499F9ABC6EQ37013260-E514C92A-2F11-48FD-B8FC-38A39BEEBFDCQ37037314-82E029A4-F7FC-4B8D-9A9B-4046661A4895Q37309929-99C0DEB3-37C4-4535-B34E-EBF303662732Q37470072-98D4A055-A737-4D2D-B01C-26E872F6FF27Q37910724-2F21ACFB-F845-428C-ACF6-179A8338F229Q37975057-8CF4601D-22B2-4DB9-A527-B76F692F11AEQ38029728-912D98EC-72F1-4768-90FD-5497B7837FB6Q38422476-0365469D-7016-416C-BB83-22C5FDD520DBQ38648236-EC40AEB6-5414-430C-B176-0B629D2AF99BQ38722571-6F5A38D4-ABC7-458E-A930-80CA5F75E43CQ38747870-6175B8F9-2C15-4367-8324-D146E9634F4EQ39251743-E8DE4A4F-65C8-4960-8EF8-DB5CEB8750B3Q39404697-79607EFE-4683-4ADB-89A2-6CD5AFB3A490Q39431815-46E813C8-D32A-4719-B9F2-A8EBD84F5466Q39700328-1DFA17B7-770D-468D-9424-5927942C8CA3Q42427997-1805673F-DF9A-4FDC-BCFF-DE80FCD47935Q47738263-EDD5E3ED-2160-4757-B1DD-01265981F5F4Q52676453-6668C8F7-6CCD-4182-8FFC-DB4F21B93D3F
P2860
HSP90 inhibitor, DMAG, synergizes with radiation of lung cancer cells by interfering with base excision and ATM-mediated DNA repair
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
HSP90 inhibitor, DMAG, synergi ...... on and ATM-mediated DNA repair
@en
HSP90 inhibitor, DMAG, synergi ...... n and ATM-mediated DNA repair.
@nl
type
label
HSP90 inhibitor, DMAG, synergi ...... on and ATM-mediated DNA repair
@en
HSP90 inhibitor, DMAG, synergi ...... n and ATM-mediated DNA repair.
@nl
prefLabel
HSP90 inhibitor, DMAG, synergi ...... on and ATM-mediated DNA repair
@en
HSP90 inhibitor, DMAG, synergi ...... n and ATM-mediated DNA repair.
@nl
P2093
P2860
P1476
HSP90 inhibitor, DMAG, synergi ...... on and ATM-mediated DNA repair
@en
P2093
Ana I Robles
Jacek Capala
John Bradsher
Lyuba Varticovski
Mekel M Richardson
Modupe M Teniola
Mollie H Wright
Steven S Feis
Thuy T Koll
P2860
P304
P356
10.1158/1535-7163.MCT-07-2104
P577
2008-07-01T00:00:00Z