A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks
about
The BMI1 inhibitor PTC-209 is a potential compound to halt cellular growth in biliary tract cancer cellsChromatin modifications during repair of environmental exposure-induced DNA damage: a potential mechanism for stable epigenetic alterations.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.USP7 deubiquitinase promotes ubiquitin-dependent DNA damage signaling by stabilizing RNF168.Targeting epigenetic regulations in cancerPolycomb repressive complex 1 controls uterine decidualization.ZRF1 mediates remodeling of E3 ligases at DNA lesion sites during nucleotide excision repair.CBX Chromodomain Inhibition Enhances Chemotherapy Response in Glioblastoma Multiforme.Unique epigenetic gene profiles define human breast cancers with poor prognosis.Polycomb group proteins--epigenetic repressors with emerging roles in melanocytes and melanoma.Linking Cancer Metabolism to DNA Repair and Accelerated Senescence.The nucleosome: orchestrating DNA damage signaling and repair within chromatin.On-site remodeling at chromatin: How multiprotein complexes are rebuilt during DNA repair and transcriptional activation.Polycomb complex PRC1 as gatekeeper of intestinal stem cell identityBMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1.Human BRCA1-BARD1 ubiquitin ligase activity counteracts chromatin barriers to DNA resection.Polycomb protein RING1A limits hematopoietic differentiation in myelodysplastic syndromes.Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte.SUMO, a small, but powerful, regulator of double-strand break repair.Next-Generation Drugs and Probes for Chromatin Biology: From Targeted Protein Degradation to Phase Separation
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P2860
A small molecule inhibitor of polycomb repressive complex 1 inhibits ubiquitin signaling at DNA double-strand breaks
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 30 July 2013
@en
vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
A small molecule inhibitor of ...... ng at DNA double-strand breaks
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A small molecule inhibitor of ...... g at DNA double-strand breaks.
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type
label
A small molecule inhibitor of ...... ng at DNA double-strand breaks
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A small molecule inhibitor of ...... g at DNA double-strand breaks.
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prefLabel
A small molecule inhibitor of ...... ng at DNA double-strand breaks
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A small molecule inhibitor of ...... g at DNA double-strand breaks.
@nl
P2093
P2860
P356
P1476
A small molecule inhibitor of ...... ng at DNA double-strand breaks
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P2093
Darin McDonald
Hilmar Strickfaden
Zhizhong Xu
P2860
P304
26944-26954
P356
10.1074/JBC.M113.461699
P407
P577
2013-07-30T00:00:00Z