Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. - Wikidata - awgldk - TriplyDB

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

http://www.wikidata.org/entity/Q37171556

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A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusions Conjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUS Accumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer disease Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability Neuropathology of non-Alzheimer degenerative disorders Mechanisms of granulin deficiency: lessons from cellular and animal models Therapeutic and diagnostic challenges for frontotemporal dementia Hyperphosphorylation as a defense mechanism to reduce TDP-43 aggregation TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.The complex molecular biology of amyotrophic lateral sclerosis (ALS)A 43-kDa TDP-43 species is present in aggregates associated with frontotemporal lobar degeneration The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43 β-amyloid triggers ALS-associated TDP-43 pathology in AD models TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy.Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43 Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice.CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis.Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants.Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration.Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice Neuropathologic heterogeneity does not impair florbetapir-positron emission tomography postmortem correlates FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage Classification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43.Formation and spreading of TDP-43 aggregates in cultured neuronal and glial cells demonstrated by time-lapse imaging.The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanism Ubiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly.Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chains Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome The role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia.FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration.TAR DNA-binding protein 43 in neurodegenerative disease.Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsy Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.Progressive nonfluent aphasia: a rare clinical subtype of FTLD-TDP in Japan.

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Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.

http://www.wikidata.org/entity/Q37171556

description

article científic

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article scientifique

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articolo scientifico

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bilimsel makale

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scientific article published on July 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis.

@en

Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis.

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type

label

Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis.

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Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis.

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prefLabel

Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis.

@en

Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis.

@nl

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Annals of Neurology

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Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis

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Francisco Baralle

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Fuyuki Kametani

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Haruhiko Akiyama

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Imaharu Nakano

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Mari Yoshida

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Masato Hasegawa

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Mitsuya Morita

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Tatsuro Oda

http://www.w3.org/2001/XMLSchema#string

Tetsuaki Arai

http://www.w3.org/2001/XMLSchema#string

Thomas G Beach

http://www.w3.org/2001/XMLSchema#string

P2860

Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis

Synucleins are a novel class of substrates for G protein-coupled receptor kinases

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

TDP-43 binds heterogeneous nuclear ribonucleoprotein A/B through its C-terminal tail: an important region for the inhibition of cystic fibrosis transmembrane conductance regulator exon 9 splicing

The casein kinase Ialpha isoform is both physically positioned and functionally competent to regulate multiple events of mRNA metabolism

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60-70

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scholarly article

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10.1002/ANA.21425

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1

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64

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Emanuele Buratti

Kuniaki Tsuchiya

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2008-07-01T00:00:00Z

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5309514

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18546284

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amyotrophic lateral sclerosis

phosphorylation

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2674108

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