Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
about
A seeding reaction recapitulates intracellular formation of Sarkosyl-insoluble transactivation response element (TAR) DNA-binding protein-43 inclusionsConjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUSAccumulation of transactive response DNA binding protein 43 in mild cognitive impairment and Alzheimer diseaseRapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instabilityNeuropathology of non-Alzheimer degenerative disordersMechanisms of granulin deficiency: lessons from cellular and animal modelsTherapeutic and diagnostic challenges for frontotemporal dementiaHyperphosphorylation as a defense mechanism to reduce TDP-43 aggregationTDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.The complex molecular biology of amyotrophic lateral sclerosis (ALS)A 43-kDa TDP-43 species is present in aggregates associated with frontotemporal lobar degenerationThe tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43β-amyloid triggers ALS-associated TDP-43 pathology in AD modelsTARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathyTDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degenerationPhosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy.Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43Overexpression of ALS-associated p.M337V human TDP-43 in mice worsens disease features compared to wild-type human TDP-43 mice.CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis.Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress.Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants.Plasma phosphorylated-TDP-43 protein levels correlate with brain pathology in frontotemporal lobar degeneration.Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient miceNeuropathologic heterogeneity does not impair florbetapir-positron emission tomography postmortem correlatesFUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damageClassification of FTLD-TDP cases into pathological subtypes using antibodies against phosphorylated and non-phosphorylated TDP43.Formation and spreading of TDP-43 aggregates in cultured neuronal and glial cells demonstrated by time-lapse imaging.The C-terminal TDP-43 fragments have a high aggregation propensity and harm neurons by a dominant-negative mechanismUbiquilin modifies TDP-43 toxicity in a Drosophila model of amyotrophic lateral sclerosis (ALS).Common variant in GRN is a genetic risk factor for hippocampal sclerosis in the elderly.Multiplex SILAC analysis of a cellular TDP-43 proteinopathy model reveals protein inclusions associated with SUMOylation and diverse polyubiquitin chainsTransactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndromeThe role of transactive response DNA-binding protein-43 in amyotrophic lateral sclerosis and frontotemporal dementia.FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration.TAR DNA-binding protein 43 in neurodegenerative disease.Phosphorylated TDP-43 pathology and hippocampal sclerosis in progressive supranuclear palsyCytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.Progressive nonfluent aphasia: a rare clinical subtype of FTLD-TDP in Japan.
P2860
Q24632492-B8C41E00-3818-4A0A-8E36-889C6965E1BFQ24634807-1E3DCB8B-B34B-4C01-8A67-EABC9FD525B1Q24634907-2A42FDBB-0689-403F-9F2B-444FFC2B9353Q24648173-CACA8AE2-2343-4066-A39A-873B93758D73Q24657571-21271F19-C43A-4361-B343-C7951D919B87Q26824221-577BB38A-23FF-4C7E-8F20-08CD5F11BE0BQ26998919-9DB1C382-6932-49C5-9243-767911E0A35BQ27325625-8808ED21-9579-4184-B743-2EA42FD3637CQ28080628-078BB3A6-213D-4E0D-BBC7-7374300887BFQ28263899-05666346-25F5-41C6-A6EE-7A1DCDB23F81Q28488462-5530C1CD-CD6A-4F1E-80ED-7DCE6DDBBB21Q28542476-BB4131CB-85E9-4D08-8A00-6D7D9C453DF6Q28580544-AF391CE8-35EA-4D43-A4B9-DF252A22D75FQ28749802-1EF21C4B-A60F-4010-AF34-825185C7239EQ30493749-DD106566-A84D-4B5A-850C-D8B68737F621Q30499509-13627369-C098-4D6A-B4A0-2744E7FB700CQ30505515-24D1B8F9-1316-47AE-8A72-CD5148A37E83Q30541711-8B606BE5-369C-4FFD-9111-74170ABA851DQ30544943-171B73C5-5332-494D-ABD2-ADC7CBED0F4DQ30574827-39CFF82D-9E63-4014-8C42-CB1BD64EE57AQ30574944-FDFF266D-06FA-425E-B166-653C3D19FA8BQ31122876-D6CBC533-0F83-440E-A2A3-D4ABAA05AEAAQ33361835-B2740459-4B6A-4DB0-9A64-E09FF5726F4BQ33601762-3F507522-803B-4813-8ADC-B9403040C3EBQ33615151-8EBB4507-3347-480E-8B3D-03180B52AD17Q33683377-49AE46BC-3F8A-4C1B-BF8D-65A3B45ABD2BQ33707858-FA13B47D-8F7E-45E9-9B1F-057DFA130224Q33715607-DE80F97D-C38B-49CB-BE06-1CD022E29B59Q33783811-3E5D6EB6-59FE-4875-A5B0-0EE3CD886086Q33786698-CD0917A4-E1EA-4B01-8C4F-2DC0E22B05F3Q33799562-3ED23935-9A96-4A6F-AAD5-CC0288AB8736Q33808785-C18BA8DE-F816-4E24-8B82-A42C7DB2B841Q33812891-A0AFD9DF-0FC5-418F-BF18-B3FC938F1E69Q33830061-347F5AC1-33F0-4466-8B7D-F9CBCBF2FD04Q33847532-48AC625B-6826-4C85-A18F-E63BE3160FC0Q33922335-63DEA274-5FF5-49A7-A1A9-45E6994E682FQ33941040-983E740D-35D3-4F38-BC4F-2648C15E8A65Q33984304-468F056A-9AAC-4EFE-896A-BE096933D6D3Q33987984-69272181-2B9A-410A-99D7-AC1AF2592A4CQ34042043-94DF1558-A91C-466B-A08E-33A1044826AE
P2860
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on July 2008
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis.
@en
Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis.
@nl
type
label
Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis.
@en
Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis.
@nl
prefLabel
Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis.
@en
Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis.
@nl
P2093
P2860
P50
P356
P1433
P1476
Phosphorylated TDP-43 in front ...... amyotrophic lateral sclerosis
@en
P2093
Francisco Baralle
Fuyuki Kametani
Haruhiko Akiyama
Imaharu Nakano
Mari Yoshida
Masato Hasegawa
Mitsuya Morita
Tatsuro Oda
Tetsuaki Arai
Thomas G Beach
P2860
P356
10.1002/ANA.21425
P577
2008-07-01T00:00:00Z