Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics.
about
The consequences of selective inhibition of signal transducer and activator of transcription 3 (STAT3) tyrosine705 phosphorylation by phosphopeptide mimetic prodrugs targeting the Src homology 2 (SH2) domainTargeting SH2 domains in breast cancerDisruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.Molecular disruption of oncogenic signal transducer and activator of transcription 3 (STAT3) protein.Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain bindersSTAT inhibitors for cancer therapy.A phosphopeptide mimetic prodrug targeting the SH2 domain of Stat3 inhibits tumor growth and angiogenesis.Synthesis of phosphatase-stable, cell-permeable peptidomimetic prodrugs that target the SH2 domain of Stat3Structure-affinity relationships of glutamine mimics incorporated into phosphopeptides targeted to the SH2 domain of signal transducer and activator of transcription 3.A molecular model for the differential activation of STAT3 and STAT6 by the herpesviral oncoprotein tip.Progress towards the development of SH2 domain inhibitors.Antagonism of the Stat3-Stat3 protein dimer with salicylic acid based small molecules.Potent and selective phosphopeptide mimetic prodrugs targeted to the Src homology 2 (SH2) domain of signal transducer and activator of transcription 3.Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein.Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling.Structure-Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3).Signal transducer and activator of transcription 3 (STAT3): a promising target for anticancer therapy.Structure-Based Design of Conformationally Constrained, Cell-Permeable STAT3 Inhibitors.
P2860
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P2860
Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
Solid-phase synthesis of Stat3 ...... threonine as glutamine mimics.
@en
Solid-phase synthesis of Stat3 ...... threonine as glutamine mimics.
@nl
type
label
Solid-phase synthesis of Stat3 ...... threonine as glutamine mimics.
@en
Solid-phase synthesis of Stat3 ...... threonine as glutamine mimics.
@nl
prefLabel
Solid-phase synthesis of Stat3 ...... threonine as glutamine mimics.
@en
Solid-phase synthesis of Stat3 ...... threonine as glutamine mimics.
@nl
P2093
P2860
P1476
Solid-phase synthesis of Stat3 ...... threonine as glutamine mimics.
@en
P2093
John S McMurray
Patricia A Heard
Pijus K Mandal
Xiaomin Chen
Zhiyong Ren
P2860
P304
P356
10.1016/J.BMCL.2006.10.099
P407
P577
2006-11-06T00:00:00Z