Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation.
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Cell division cycle 6, a mitotic substrate of polo-like kinase 1, regulates chromosomal segregation mediated by cyclin-dependent kinase 1 and separasePolo-like kinase 1, on the rise from cell cycle regulation to prostate cancer developmentPlk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell linesNek1 and TAZ interact to maintain normal levels of polycystin 2SCF(FBXW7α) modulates the intra-S-phase DNA-damage checkpoint by regulating Polo like kinase-1 stabilityAn image-based biosensor assay strategy to screen for modulators of the microRNA 21 biogenesis pathwayB-Myb is critical for proper DNA duplication during an unperturbed S phase in mouse embryonic stem cellsAn arrayed genome-scale lentiviral-enabled short hairpin RNA screen identifies lethal and rescuer gene candidatesIdentification of potential Plk1 targets in a cell-cycle specific proteome through structural dynamics of kinase and Polo box-mediated interactionsPolo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo.Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease.Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stressLoss of p21Cip1/CDKN1A renders cancer cells susceptible to Polo-like kinase 1 inhibitionPolo-like kinase 1 (Plk1): an Unexpected Player in DNA Replication.Identification of rictor as a novel substrate of Polo-like kinase 1.Immunohistochemical detection of Polo-like kinase-1 (PLK1) in primary breast cancer is associated with TP53 mutation and poor clinical outcomValidation of Polo-like kinase 1 as a therapeutic target in pancreatic cancer cellsCentrosomal protein FOR20 is essential for S-phase progression by recruiting Plk1 to centrosomes.Functional genomic screens identify CINP as a genome maintenance protein.Polo-like kinase 1 inhibition diminishes acquired resistance to epidermal growth factor receptor inhibition in non-small cell lung cancer with T790M mutations.The substrates of Plk1, beyond the functions in mitosis.S-phase-coupled apoptosis in tumor suppression.Polo-like kinase 1 inhibition causes decreased proliferation by cell cycle arrest, leading to cell death in glioblastoma.Sensitivity of TP53-Mutated Cancer Cells to the Phytoestrogen Genistein Is Associated With Direct Inhibition of Plk1 Activity.p53-dependent repression of polo-like kinase-1 (PLK1).Differential Cellular Effects of Plk1 Inhibitors Targeting the ATP-binding Domain or Polo-box Domain.Plk1: unexpected roles in DNA replication.Polo-like kinase 1 is essential for the first mitotic division in the mouse embryo.The responses of cancer cells to PLK1 inhibitors reveal a novel protective role for p53 in maintaining centrosome separation.Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer.Plk1-mediated stabilization of 53BP1 through USP7 regulates centrosome positioning to maintain bipolarity.
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Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation.
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
@pt
bilimsel makale
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scientific article published on 16 March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation.
@en
Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation.
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type
label
Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation.
@en
Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation.
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prefLabel
Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation.
@en
Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation.
@nl
P2860
P356
P1476
Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation.
@en
P2093
Hyungshin Yim
Raymond L Erikson
P2860
P304
P356
10.1128/MCB.01277-08
P407
P577
2009-03-16T00:00:00Z