Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.
about
Binding modes of CCR5-targetting HIV entry inhibitors: partial and full antagonistsElucidating a key anti-HIV-1 and cancer-associated axis: the structure of CCL5 (Rantes) in complex with CCR5.Structural insights from binding poses of CCR2 and CCR5 with clinically important antagonists: a combined in silico studyComputationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.Small molecule receptor agonists and antagonists of CCR3 provide insight into mechanisms of chemokine receptor activation.Structural and molecular interactions of CCR5 inhibitors with CCR5.Structural Analysis of Chemokine Receptor-Ligand Interactions.Constitutively active CCR5 chemokine receptors differ in mediating HIV envelope-dependent fusion.New insights into the mechanisms whereby low molecular weight CCR5 ligands inhibit HIV-1 infectionComparison of three GPCR structural templates for modeling of the P2Y12 nucleotide receptor.Allosteric model of maraviroc binding to CC chemokine receptor 5 (CCR5).CCR5 mutations distinguish N-terminal modifications of RANTES (CCL5) with agonist versus antagonist activity.Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants.Mutagenic mapping suggests a novel binding mode for selective agonists of M1 muscarinic acetylcholine receptorsThe seventh transmembrane domains of the delta and kappa opioid receptors have different accessibility patterns and interhelical interactions.D6 and the atypical chemokine receptor family: novel regulators of immune and inflammatory processes.Chemokine receptors and other G protein-coupled receptors.Targeting chemokine receptors in allergic disease.Pharmacological modulation of chemokine receptor function.An overview of recent developments in GPCR modelling: methods and validation.Molecular Mechanism of Action for Allosteric Modulators and Agonists in CC-chemokine Receptor 5 (CCR5).New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule BindingStructure/function relationships of CCR8 agonists and antagonists. Amino-terminal extension of CCL1 by a single amino acid generates a partial agonist.Ser and Thr residues modulate the conformation of pro-kinked transmembrane alpha-helices.Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist.Investigation of Inhibition Mechanism of Chemokine Receptor CCR5 by Micro-second Molecular Dynamics Simulations.Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation.By interacting with the C-terminal Phe of apelin, Phe255 and Trp259 in helix VI of the apelin receptor are critical for internalization.The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle.Computational modeling of human coreceptor CCR5 antagonist as a HIV-1 entry inhibitor: using an integrated homology modeling, docking, and membrane molecular dynamics simulation analysis approach.Partial Agonist and Biased Signaling Properties of the Synthetic Enantiomers J113863/UCB35625 at Chemokine Receptors CCR2 and CCR5.
P2860
Q24658283-FB89E9BF-A10A-452F-9EF5-D252D52C0A85Q27309182-4C80181D-245D-4130-9C6B-F418F6D81A36Q28481687-806DC08D-0F96-4FDC-96F4-703307862498Q30427185-DF0D6A16-2417-40BF-B492-467719A08AFAQ30956674-2EAC8AEA-F687-49DC-A6C2-BFD01C454983Q33291059-0B5FCC13-0559-4359-A511-11A3AC3F9630Q34494226-257E7685-1DA4-4ED9-8D2F-74146254CD35Q34550666-9821969F-35B7-48C4-9058-FEF31BB63542Q34565057-9B8D2DD1-20A2-4103-A50E-45B57482588FQ34568280-76232E66-AF6E-4897-810A-B25E787F6283Q35168275-E65CB1D4-2A5B-4764-9364-CD0E0DA92580Q35312348-2D63CD86-A3B8-43A8-B4B9-A3DFD10071EEQ36246273-455B46D0-4902-48D5-815C-2998A0258A39Q36911645-ED2ABF79-A9E3-4466-B8B4-FDF485542106Q37199099-0F8541C9-E914-4B28-8E8A-92C85843260CQ37208197-1071F743-7CE2-406C-AA5D-6D6A955FB43BQ37364658-751E9B9F-1D69-4D1A-8DBF-7ED9B2930DAEQ37429729-C2E84F38-4E5A-4E67-AC0F-136B3873E481Q37832529-915BAF10-892E-4B2B-915A-DD3C4151B32CQ37893687-7E3B9F60-B71D-4DB2-B7D3-75469B5D8B6DQ38089807-D8143B3C-D006-4BAC-9A6A-4801BF038178Q38796479-C642F901-EDE9-4950-89FA-E5E1D7180C3DQ38815332-1BE38212-1254-480F-8287-87F534A82930Q38862301-8591E3D2-EB86-49F1-A85D-23C0DE6991F0Q40223201-7786E345-E9F8-4882-98AB-D3AC60AC22E9Q40267255-2D021837-285B-4E7D-8E16-3D1F27F42313Q40467514-22917EDD-7A68-4180-85CB-FBC0BD0A20DDQ41037672-E30F5238-5F9F-4DB7-AA0E-0C58DA1FD72DQ42380472-ECE94945-381E-4B67-A305-55BC94E741E4Q42411890-D114C3A9-AAF3-4326-A86C-920BA6676A43Q44238580-5CD4F8F0-0B66-4152-BAB0-7ABBF6311C7EQ46477869-242A8D44-6250-4A1D-AEEC-C3CEABD29C73Q48193375-A1C12941-B35B-40D6-96DF-6FC86962E5F2
P2860
Activation of CCR5 by chemokines involves an aromatic cluster between transmembrane helices 2 and 3.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Activation of CCR5 by chemokin ...... transmembrane helices 2 and 3.
@en
Activation of CCR5 by chemokin ...... transmembrane helices 2 and 3.
@nl
type
label
Activation of CCR5 by chemokin ...... transmembrane helices 2 and 3.
@en
Activation of CCR5 by chemokin ...... transmembrane helices 2 and 3.
@nl
prefLabel
Activation of CCR5 by chemokin ...... transmembrane helices 2 and 3.
@en
Activation of CCR5 by chemokin ...... transmembrane helices 2 and 3.
@nl
P2093
P2860
P50
P356
P1476
Activation of CCR5 by chemokin ...... transmembrane helices 2 and 3.
@en
P2093
Antoine Bondue
Cédric Blanpain
Cédric Govaerts
Emmanuel Le Poul
Jean-Yves Springael
Mireia Olivella
P2860
P304
P356
10.1074/JBC.M205685200
P407
P577
2002-10-30T00:00:00Z