Location, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling. - Wikidata - awgldk - TriplyDB

Location, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling.

Location, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling.

http://www.wikidata.org/entity/Q37209196

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EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network Therapeutic potential for novel drugs targeting the type 1 cholecystokinin receptor G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei--serpentine gateways to neuroendocrine homeostasis Diversity and modularity of G protein-coupled receptor structures Novel GPCR paradigms at the μ-opioid receptor Regulation of G protein-coupled receptors by allosteric ligands CCR2 acts as scavenger for CCL2 during monocyte chemotaxis Novel Structural Approaches to Study GPCR Regulation Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins.Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3.Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis.The triplet puzzle of homologies in receptor heteromers exists also in other types of protein-protein interactions.Probing the stoichiometry of β2-adrenergic receptor phosphorylation by targeted mass spectrometry Light-dependent phosphorylation of the carboxy tail of mouse melanopsin.Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo Signal transduction by protease-activated receptors Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.Functionalized congener approach to the design of ligands for G protein-coupled receptors (GPCRs).The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner The year in G protein-coupled receptor research.A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity Constitutive phosphorylation by protein kinase C regulates D1 dopamine receptor signaling.M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1.Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail.Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling.Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor Norbin: A promising central nervous system regulator.Identification and functional characterization of the phosphorylation sites of the neuropeptide FF2 receptor.Arrestins differentially regulate histamine- and oxytocin-evoked phospholipase C and mitogen-activated protein kinase signalling in myometrial cells.Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code.Differential temporal and spatial regulation of somatostatin receptor phosphorylation and dephosphorylation.A single amino acid residue controls Ca2+ signaling by an octopamine receptor from Drosophila melanogaster.G protein-coupled receptors--recent advances S-nitrosylation-regulated GPCR signaling.

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Location, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling.

http://www.wikidata.org/entity/Q37209196

description

article científic

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bilimsel makale

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scientific article published on 06 July 2008

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Location, location, location.. ...... cell-type-specific signalling.

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Location, location, location.. ...... cell-type-specific signalling.

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type

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Location, location, location.. ...... cell-type-specific signalling.

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Location, location, location.. ...... cell-type-specific signalling.

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Location, location, location.. ...... cell-type-specific signalling.

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Location, location, location.. ...... cell-type-specific signalling.

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J.TIPS.2008.05.006

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Trends in Pharmacological Sciences

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Location, location, location.. ...... cell-type-specific signalling.

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Adrian J Butcher

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Andrew B Tobin

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Kok Choi Kong

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Creative Commons Attribution 3.0 Unported

P2860

Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha

Functional specialization of beta-arrestin interactions revealed by proteomic analysis

The structural basis of arrestin-mediated regulation of G-protein-coupled receptors

Molecular mechanisms of ligand binding, signaling, and regulation within the superfamily of G-protein-coupled receptors: molecular modeling and mutagenesis approaches to receptor structure and function.

Endogenous G protein-coupled receptor kinase 6 Regulates M3 muscarinic acetylcholine receptor phosphorylation and desensitization in human SH-SY5Y neuroblastoma cells

Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function

Transduction of receptor signals by beta-arrestins

Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor

Insulin stimulates sequestration of beta-adrenergic receptors and enhanced association of beta-adrenergic receptors with Grb2 via tyrosine 350

Dynamic complexes of beta2-adrenergic receptors with protein kinases and phosphatases and the role of gravin

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413-420

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10.1016/J.TIPS.2008.05.006

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8

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2008-07-06T00:00:00Z

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5245457

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18606460

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phosphorylation

transport protein

cell surface receptor

G protein-coupled receptor

membrane proteins

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2880250

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