N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling
about
Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophyThe Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cellsThe neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter moleculesTwo adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinasep66Shc as a switch in bringing about contrasting responses in cell growth: implications on cell proliferation and apoptosisShcB and ShcC activation by the Trk family of receptor tyrosine kinasesActivation of anaplastic lymphoma kinase is responsible for hyperphosphorylation of ShcC in neuroblastoma cell linesRAI(ShcC/N-Shc)-dependent recruitment of GAB 1 to RET oncoproteins potentiates PI 3-K signalling in thyroid tumorsLinkage and association studies in African- and Caucasian-American populations demonstrate that SHC3 is a novel susceptibility locus for nicotine dependenceAnalysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinaseDifferential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairmentThe ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryoNon-redundant role of Shc in Erk activation by cytoskeletal reorganizationSck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling.Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc.DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profilesBrain insulin receptor causes activity-dependent current suppression in the olfactory bulb through multiple phosphorylation of Kv1.3.Biological role of anaplastic lymphoma kinase in neuroblastoma.Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.The function of the neuronal proteins Shc and huntingtin in stem cells and neurons: pharmacologic exploitation for human brain diseases.Cathepsin Inhibition Prevents Autophagic Protein Turnover and Downregulates Insulin Growth Factor-1 Receptor-Mediated Signaling in NeuroblastomaInvolvement of the neuronal phosphotyrosine signal adaptor N-Shc in kainic acid-induced epileptiform activity.p66Shc, a multifaceted protein linking Erk signalling, glucose metabolism, and oxidative stress.Teaching an old dogma new tricks: twenty years of Shc adaptor signalling.Multiple system atrophy: genetic or epigenetic?Distinct role of ShcC docking protein in the differentiation of neuroblastoma.Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA.Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adapter molecules.Comparative expression profiles of Trk receptors and Shc-related phosphotyrosine adapters during retinal development: potential roles of N-Shc/ShcC in brain-derived neurotrophic factor signal transduction and modulation.Insights into the Shc Family of Adaptor Proteins.Molecular cloning of EDG-3 and N-Shc genes from the puffer fish, Fugu rubripes, and conservation of synteny with the human genome.Alteration of retinal intrinsic survival signal and effect of alpha2-adrenergic receptor agonist in the retina of the chronic ocular hypertension rat.Different Effects of p52SHC1 and p52SHC3 on the Cell Cycle of Neurons and Neural Stem Cells.Melanoma: targeting signaling pathways and RaLP
P2860
Q21198881-5EE0F078-56CF-4332-946A-F752D517F6E1Q24532025-A7564456-2A94-47C8-91F6-41A60C76816CQ24540169-987C771C-4E46-40C7-B0C0-A312639084C8Q24540188-7CEB0F0E-6AC6-4514-9DCB-444187B78819Q24654769-0BF90F11-96A3-4845-8EDE-FD4DADC9B965Q28084081-7847D77A-1280-4CE9-8903-0FFFA1EF55F5Q28217215-C108B82D-14A6-42E9-B47F-D142D6DD8FD0Q28218528-82983199-AEFC-41D3-BDBC-D78213BC94B3Q28254955-89F7386A-D57F-4EB6-8F1B-6FE04B1402A5Q28279797-C08CB646-B76D-46B2-B39D-8F9E714897CFQ28507045-A64C12AA-A5D1-4189-8C38-83CF5DB8D209Q28564997-69FCF08D-F48C-4A7B-BAA2-1ED6A702953FQ28586248-BE6CA590-32DC-440A-ADB7-8B709BD718BEQ28590354-B859FAF6-66D7-438A-BD1F-EC380EFFEA03Q33292515-AD17AB43-73F2-4A4B-8ECD-AE9177A9BD90Q33402663-38E2C251-D2AC-417B-9BF4-809EC17894C2Q34994251-960DB1FC-CBE6-4F76-A84C-137C7747CF39Q35078423-1AD8DB4E-28E8-47FA-8E2D-6991B02850CAQ35084934-40B3937C-8E39-4C75-87DE-CD9D292864E8Q35684970-A6D838E9-0BA6-4381-8B9A-E0516BC29FF6Q36167442-AB85D185-0858-49B1-84E9-54B4B7C1B745Q36559668-7D0FF3A9-1D4F-42BB-B903-478947A0281DQ36980493-91807279-78A8-42BC-880E-0389DDA8A059Q37867129-AF90B4EE-23E9-49D7-A94E-F95737A05716Q38042699-5EF1D2D8-B371-4754-9D27-F81CFA41542EQ38303573-2A5EB97D-FC4F-4ACA-8AD1-67763002A82CQ39919348-7851E2C9-4AE1-4A62-A794-86CFF37D70FFQ40743809-9430BA91-0FF5-4609-8C1F-CDAA57E064EBQ43854593-45C5A57F-B17D-40C5-92ED-E72D45866778Q44059838-F9A2E0FF-7B63-43CB-8DB4-C759E615DABFQ47164766-B867FCF1-B033-4A84-B4DC-DA53EF3BA44CQ47923795-17FD126F-AD56-4BDA-BEDA-32A8B1F5084FQ48100772-E8EEBC0D-3412-4B7B-9AE2-FAFE6A1EE6EAQ52937782-AE863AF0-25B7-460D-9573-425C7A46899EQ58882374-1772AC78-3B1D-4576-AE9E-67F7E4D1B950
P2860
N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling
description
1998 nî lūn-bûn
@nan
1998 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի մարտին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
N-Shc and Sck, two neuronally ...... neurotrophin and Src signaling
@ast
N-Shc and Sck, two neuronally ...... neurotrophin and Src signaling
@en
N-Shc and Sck, two neuronally ...... neurotrophin and Src signaling
@nl
type
label
N-Shc and Sck, two neuronally ...... neurotrophin and Src signaling
@ast
N-Shc and Sck, two neuronally ...... neurotrophin and Src signaling
@en
N-Shc and Sck, two neuronally ...... neurotrophin and Src signaling
@nl
prefLabel
N-Shc and Sck, two neuronally ...... neurotrophin and Src signaling
@ast
N-Shc and Sck, two neuronally ...... neurotrophin and Src signaling
@en
N-Shc and Sck, two neuronally ...... neurotrophin and Src signaling
@nl
P2093
P2860
P3181
P356
P1476
N-Shc and Sck, two neuronally ...... neurotrophin and Src signaling
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.273.12.6960
P407
P577
1998-03-20T00:00:00Z