Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. - Wikidata - awgldk - TriplyDB

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.

Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.

http://www.wikidata.org/entity/Q37223903

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A beta version of life: p110β takes center stage p37δ is a new isoform of PI3K p110δ that increases cell proliferation and is overexpressed in tumors Should individual PI3 kinase isoforms be targeted in cancer?Phosphoinositide 3-kinase: friend and foe in cardiovascular disease Nuclear PI3K signaling in cell growth and tumorigenesis Phosphoinositides: tiny lipids with giant impact on cell regulation Phosphoinositides: Key modulators of energy metabolism Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism A selective inhibitor reveals PI3Kγ dependence of T(H)17 cell differentiation The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.Signaling by the phosphoinositide 3-kinase family in immune cells Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity Ras is an indispensable coregulator of the class IB phosphoinositide 3-kinase p87/p110gamma Targeting the phosphoinositide 3-kinase pathway in cancer The proline-rich tyrosine kinase Pyk2 regulates platelet integrin αIIbβ3 outside-in signaling.Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair.RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms.Regulation of p110delta PI 3-kinase gene expression.PI3Kgamma-dependent signaling in mouse olfactory receptor neurons.PIK3CA and PIK3CB inhibition produce synthetic lethality when combined with estrogen deprivation in estrogen receptor-positive breast cancer.Novel insights into G protein and G protein-coupled receptor signaling in cancer Inhibitory odorant signaling in Mammalian olfactory receptor neurons.Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility.Phosphoinositide 3-kinase pathway activation in phosphate and tensin homolog (PTEN)-deficient prostate cancer cells is independent of receptor tyrosine kinases and mediated by the p110beta and p110delta catalytic subunits.Discovery of novel anticancer therapeutics targeting the PI3K/Akt/mTOR pathway.A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice.Activity of any class IA PI3K isoform can sustain cell proliferation and survival.Phosphatidylinositol 3-kinase: the oncoprotein.The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy.A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.Downregulation of PI3Kcb utilizing adenovirus-mediated transfer of siRNA attenuates bone cancer pain.Exploring the transcriptome space of a recombinant BHK cell line through next generation sequencing.Specific roles of the p110alpha isoform of phosphatidylinsositol 3-kinase in hepatic insulin signaling and metabolic regulation.Role of phosphoinositide 3-OH kinase p110β in skeletal myogenesis A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting.PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance.Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase

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Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development.

http://www.wikidata.org/entity/Q37223903

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article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 09 September 2008

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vedecký článok

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vetenskaplig artikel

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vědecký článek

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name

Phosphoinositide 3-kinase p110 ...... nd cancer but not development.

@en

Phosphoinositide 3-kinase p110 ...... nd cancer but not development.

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type

label

Phosphoinositide 3-kinase p110 ...... nd cancer but not development.

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Phosphoinositide 3-kinase p110 ...... nd cancer but not development.

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prefLabel

Phosphoinositide 3-kinase p110 ...... nd cancer but not development.

@en

Phosphoinositide 3-kinase p110 ...... nd cancer but not development.

@nl

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SCISIGNAL.1161577

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Science Signaling

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Phosphoinositide 3-kinase p110 ...... nd cancer but not development.

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Carlotta Costa

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Christian Rommel

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Claudia Curcio

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Cristiano Gonella

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Cristina Rubinetto

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Elisa Ciraolo

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Emilia Turco

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Emilio Hirsch

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Erica L Martin

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Fiorella Altruda

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P2860

A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase

Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease.

PI 3-kinase p110beta: a new target for antithrombotic therapy

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

ERBB receptors and cancer: the complexity of targeted inhibitors

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10.1126/SCISIGNAL.1161577

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