Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice.
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Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapyMicroRNA-29 overexpression by adeno-associated virus suppresses fibrosis and restores muscle function in combination with micro-dystrophinA human-specific deletion in mouse Cmah increases disease severity in the mdx model of Duchenne muscular dystrophyMacrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury.Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy.Prednisolone attenuates improvement of cardiac and skeletal contractile function and histopathology by lisinopril and spironolactone in the mdx mouse model of Duchenne muscular dystrophy.mdx(⁵cv) mice manifest more severe muscle dysfunction and diaphragm force deficits than do mdx MiceDisease course in mdx:utrophin+/- mice: comparison of three mouse models of Duchenne muscular dystrophyChronic Dosing with Membrane Sealant Poloxamer 188 NF Improves Respiratory Dysfunction in Dystrophic Mdx and Mdx/Utrophin-/- MiceMineralocorticoid receptors are present in skeletal muscle and represent a potential therapeutic target.Sparing of the extraocular muscles in mdx mice with absent or reduced utrophin expression: A life span analysis.ANG1 treatment reduces muscle pathology and prevents a decline in perfusion in DMD mice.CX3CR1 deficiency delays acute skeletal muscle injury repair by impairing macrophage functions.The Angiotensin Converting Enzyme Inhibitor Lisinopril Improves Muscle Histopathology but not Contractile Function in a Mouse Model of Duchenne Muscular Dystrophy.Imatinib attenuates skeletal muscle dystrophy in mdx miceSimilar efficacy from specific and non-specific mineralocorticoid receptor antagonist treatment of muscular dystrophy mice.Current Translational Research and Murine Models For Duchenne Muscular Dystrophy.Targeting fibrosis in Duchenne muscular dystrophy.Cardiac and respiratory dysfunction in Duchenne muscular dystrophy and the role of second messengers.Gene expression effects of glucocorticoid and mineralocorticoid receptor agonists and antagonists on normal human skeletal muscle.Renin-angiotensin-aldosterone system inhibitors improve membrane stability and change gene-expression profiles in dystrophic skeletal muscles.BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model.Understanding the process of fibrosis in Duchenne muscular dystrophy.Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin(+/-) mice.VEGF induces stress fiber formation in fibroblasts isolated from dystrophic muscle.Long-term Exon Skipping Studies With 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in Dystrophic Mouse Models.Impaired respiratory function in mdx and mdx/utrn(+/-) mice.Novel and optimized strategies for inducing fibrosis in vivo: focus on Duchenne Muscular DystrophyEarly treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice.Identification and Function of Fibrocytes in Skeletal Muscle Injury Repair and Muscular Dystrophy.α-smooth muscle actin is not a marker of fibrogenic cell activity in skeletal muscle fibrosis.CCR2 deficiency does not provide sustained improvement of muscular dystrophy in mdx5cv mice.Characterization of neuromuscular synapse function abnormalities in multiple Duchenne muscular dystrophy mouse models.Fibrosis-Inducing Strategies in Regenerating Dystrophic and Normal Skeletal Muscle.Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice.
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P2860
Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 24 September 2007
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Haploinsufficiency of utrophin ...... tion and fibrosis in mdx mice.
@en
Haploinsufficiency of utrophin ...... tion and fibrosis in mdx mice.
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type
label
Haploinsufficiency of utrophin ...... tion and fibrosis in mdx mice.
@en
Haploinsufficiency of utrophin ...... tion and fibrosis in mdx mice.
@nl
prefLabel
Haploinsufficiency of utrophin ...... tion and fibrosis in mdx mice.
@en
Haploinsufficiency of utrophin ...... tion and fibrosis in mdx mice.
@nl
P2093
P2860
P1476
Haploinsufficiency of utrophin ...... tion and fibrosis in mdx mice.
@en
P2093
Georgiana Cheng
Henry J Kaminski
Jill A Rafael-Fortney
Liping Liu
Ping Huang
Richard M Ransohoff
Xiaohua Zhou
Xinyu S Zhao
P2860
P304
P356
10.1016/J.JNS.2007.08.029
P577
2007-09-24T00:00:00Z