CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn.
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Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signalingDistinct intracellular localization of Lck and Fyn protein tyrosine kinases in human T lymphocytesFYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cellsCD5 negatively regulates the T-cell antigen receptor signal transduction pathway: involvement of SH2-containing phosphotyrosine phosphatase SHP-1The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase p56lckPhosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinaseTyrosine phosphorylation of Grb2-associated proteins correlates with phospholipase C gamma 1 activation in T cellsImplication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 productionThe regulation of CD5 expression in murine T cellsFunctional Heterogeneity in CD4(+) T Cell Responses Against a Bacterial PathogenInteraction of the CD5 cytoplasmic domain with the Ca2+/calmodulin-dependent kinase IIdeltaSrc-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.Determination of the tyrosine phosphorylation sites in the T cell transmembrane glycoprotein CD5.CD5 is dissociated from the B-cell receptor in B cells from bovine leukemia virus-infected, persistently lymphocytotic cattle: consequences to B-cell receptor-mediated apoptosis.CD6 as a therapeutic target in autoimmune diseases: successes and challenges.Rare expression of T-cell markers in classical Hodgkin's lymphoma.p56lck interacts via its src homology 2 domain with the ZAP-70 kinase.Differential association of protein tyrosine kinases with the T cell receptor is linked to the induction of anergy and its prevention by B7 family-mediated costimulation.CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity.A conserved enhancer element differentially regulates developmental expression of CD5 in B and T cells.Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responsesA new pathway of CD5 glycoprotein-mediated T cell inhibition dependent on inhibitory phosphorylation of Fyn kinase.Signaling through CD5 activates a pathway involving phosphatidylinositol 3-kinase, Vav, and Rac1 in human mature T lymphocytesThe CD3-gamma delta epsilon transducing module mediates CD38-induced protein-tyrosine kinase and mitogen-activated protein kinase activation in Jurkat T cells.Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5.Tyrosine phosphorylation and association with phospholipase C gamma-1 of the GAP-associated 62-kD protein after CD2 stimulation of Jurkat T cell.Identification of a novel dimeric phosphoprotein (PP29/30) associated with signaling receptors in human T lymphocytes and natural killer cells.Immunomodulatory effects of soluble CD5 on experimental tumor models.An influence of CD5 on the selection of CD4-lineage T cells.Tuning T Cell Signaling Sensitivity Alters the Behavior of CD4+ T Cells During an Immune Response.T Cell Calcium Signaling Regulation by the Co-Receptor CD5.
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CD5 acts as a tyrosine kinase substrate within a receptor complex comprising T-cell receptor zeta chain/CD3 and protein-tyrosine kinases p56lck and p59fyn.
description
article científic
@ca
article scientifique
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articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on October 1992
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
CD5 acts as a tyrosine kinase ...... ine kinases p56lck and p59fyn.
@en
CD5 acts as a tyrosine kinase ...... ine kinases p56lck and p59fyn.
@nl
type
label
CD5 acts as a tyrosine kinase ...... ine kinases p56lck and p59fyn.
@en
CD5 acts as a tyrosine kinase ...... ine kinases p56lck and p59fyn.
@nl
prefLabel
CD5 acts as a tyrosine kinase ...... ine kinases p56lck and p59fyn.
@en
CD5 acts as a tyrosine kinase ...... ine kinases p56lck and p59fyn.
@nl
P2093
P2860
P356
P1476
CD5 acts as a tyrosine kinase ...... ine kinases p56lck and p59fyn.
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.19.9311
P407
P577
1992-10-01T00:00:00Z