Darpp-32 and its truncated variant t-Darpp have antagonistic effects on breast cancer cell growth and herceptin resistance.
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DARPP-32: from neurotransmission to cancerVersican G3 domain modulates breast cancer cell apoptosis: a mechanism for breast cancer cell response to chemotherapy and EGFR therapyt-Darpp Promotes Enhanced EGFR Activation and New Drug Synergies in Her2-Positive Breast Cancer CellsA pathway-based classification of breast cancer integrating data on differentially expressed genes, copy number variations and microRNA target genesEffects of DARPP-32 Genetic Variation on Prefrontal Cortex Volume and Episodic Memory Performance.Dopamine and cAMP regulated phosphoprotein MW 32 kDa is overexpressed in early stages of gastric tumorigenesis.Darpp-32 and t-Darpp are differentially expressed in normal and malignant mouse mammary tissue.t-DARPP regulates phosphatidylinositol-3-kinase-dependent cell growth in breast cancer.BCDB - A database for breast cancer research and information.Beyond the dopamine receptor: regulation and roles of serine/threonine protein phosphatases.DARPP-32, Jack of All Trades… Master of Which?Growth differentiation factor 15 (GDF15)-mediated HER2 phosphorylation reduces trastuzumab sensitivity of HER2-overexpressing breast cancer cells.Regulation of ERBB2 receptor by t-DARPP mediates trastuzumab resistance in human esophageal adenocarcinoma.t-Darpp overexpression in HER2-positive breast cancer confers a survival advantage in lapatinib.DARPP32, STAT5 and STAT3 mRNA expression ratios in glioblastomas are associated with patient outcome.Protein kinase A activation confers resistance to trastuzumab in human breast cancer cell lines.t-Darpp stimulates protein kinase A activity by forming a complex with its RI regulatory subunit.Genetic and Functional Analysis of Polymorphisms in the Human Dopamine Receptor and Transporter Genes in Small Cell Lung Cancer.3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing.t-Darpp is an elongated monomer that binds calcium and is phosphorylated by cyclin-dependent kinases 1 and 5.Revisiting DARPP-32 in postmortem human brain: changes in schizophrenia and bipolar disorder and genetic associations with t-DARPP-32 expression.DARPP-32 and t-DARPP promote non-small cell lung cancer growth through regulation of IKKα-dependent cell migration
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Darpp-32 and its truncated variant t-Darpp have antagonistic effects on breast cancer cell growth and herceptin resistance.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 13 July 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Darpp-32 and its truncated var ...... owth and herceptin resistance.
@en
Darpp-32 and its truncated var ...... owth and herceptin resistance.
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type
label
Darpp-32 and its truncated var ...... owth and herceptin resistance.
@en
Darpp-32 and its truncated var ...... owth and herceptin resistance.
@nl
prefLabel
Darpp-32 and its truncated var ...... owth and herceptin resistance.
@en
Darpp-32 and its truncated var ...... owth and herceptin resistance.
@nl
P2093
P2860
P1433
P1476
Darpp-32 and its truncated var ...... owth and herceptin resistance.
@en
P2093
Sarah Waliany
Susan E Kane
P2860
P356
10.1371/JOURNAL.PONE.0006220
P407
P577
2009-07-13T00:00:00Z