Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function. - Wikidata - awgldk - TriplyDB

Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function.

Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function.

http://www.wikidata.org/entity/Q37252731

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Analysis of prevalence and degree of macrocephaly in patients with germline PTEN mutations and of brain weight in Pten knock-in murine model A functional dissection of PTEN N-terminus: implications in PTEN subcellular targeting and tumor suppressor activity Germline disruption of Pten localization causes enhanced sex-dependent social motivation and increased glial production.Different conformations of phosphatase and tensin homolog, deleted on chromosome 10 (PTEN) protein within the nucleus and cytoplasm of neurons The effect of systemic PTEN antagonist peptides on axon growth and functional recovery after spinal cord injury.Naturally occurring germline and tumor-associated mutations within the ATP-binding motifs of PTEN lead to oxidative damage of DNA associated with decreased nuclear p53.ATM-mediated PTEN phosphorylation promotes PTEN nuclear translocation and autophagy in response to DNA-damaging agents in cancer cells Involvement of Endoplasmic Reticulum Stress in TULP1 Induced Retinal Degeneration.Expression of PPARγ and PTEN in human colorectal cancer: An immunohistochemical study using tissue microarray methodology.A systematic screening to identify de novo mutations causing sporadic early-onset Parkinson's disease.Cytoplasm-predominant Pten associates with increased region-specific brain tyrosine hydroxylase and dopamine D2 receptors in mouse model with autistic traits.PTEN lipid phosphatase activity and proper subcellular localization are necessary and sufficient for down-regulating AKT phosphorylation in the nucleus in Cowden syndrome.Cowden syndrome-related mutations in PTEN associate with enhanced proteasome activity.When Overgrowth Bumps Into Cancer: The PTEN-Opathies.Prognostic significance of Daxx NCR (Nuclear/Cytoplasmic Ratio) in gastric cancer.Defective phosphoinositide metabolism in autism.Chromatin PTEN is involved in DNA damage response partly through regulating Rad52 sumoylation.Identification of mutations in the PI3K-AKT-mTOR signalling pathway in patients with macrocephaly and developmental delay and/or autism.When overgrowth bumps into cancer: the PTEN-opathies.A pathogenic role for germline PTEN variants which accumulate into the nucleus.Comparative analysis of germline and somatic microlesion mutational spectra in 17 human tumor suppressor genes.

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Germline and somatic cancer-associated mutations in the ATP-binding motifs of PTEN influence its subcellular localization and tumor suppressive function.

http://www.wikidata.org/entity/Q37252731

description

article científic

@ca

article scientifique

@fr

articolo scientifico

@it

artigo científico

@pt

bilimsel makale

@tr

scientific article published on 20 May 2009

@en

vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

@da

vědecký článek

@cs

name

Germline and somatic cancer-as ...... nd tumor suppressive function.

@en

Germline and somatic cancer-as ...... nd tumor suppressive function.

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type

label

Germline and somatic cancer-as ...... nd tumor suppressive function.

@en

Germline and somatic cancer-as ...... nd tumor suppressive function.

@nl

prefLabel

Germline and somatic cancer-as ...... nd tumor suppressive function.

@en

Germline and somatic cancer-as ...... nd tumor suppressive function.

@nl

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Human Molecular Genetics

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Germline and somatic cancer-as ...... and tumor suppressive function

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Glenn P Lobo

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Kristin A Waite

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Najah T Nassif

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Sarah M Planchon

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Todd Romigh

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P2860

Ubiquitination regulates PTEN nuclear import and tumor suppression

TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta

Germline mutations and variants in the succinate dehydrogenase genes in Cowden and Cowden-like syndromes

Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers

Cancer phenomics: RET and PTEN as illustrative models

Essential role for nuclear PTEN in maintaining chromosomal integrity

Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs

Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome

Epigenetic PTEN silencing in malignant melanomas without PTEN mutation.

Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells

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2851-2862

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scholarly article

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10.1093/HMG/DDP220

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15

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18

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19457929

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