The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage
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The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathwayaPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant Numb.The Mdm2 oncoprotein interacts with the cell fate regulator NumbLNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradationThe neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNASiah-1 binds and regulates the function of NumbLoss of negative regulation by Numb over Notch is relevant to human breast carcinogenesisNumb is an endocytic proteinMouse numb is an essential gene involved in cortical neurogenesisFGF /FGFR signal induces trachea extension in the drosophila visual systemArl2- and Msps-dependent microtubule growth governs asymmetric divisionAsymmetric cell divisionMolecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairlessRNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation.The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNXPhosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborizationEpicardial spindle orientation controls cell entry into the myocardiumNumb family proteins are essential for cardiac morphogenesis and progenitor differentiationNumb is not a critical regulator of Notch-mediated cell fate decisions in the developing chick inner ear.Hox gene control of segment-specific bristle patterns in Drosophila.Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes.Numb independently antagonizes Sanpodo membrane targeting and Notch signaling in Drosophila sensory organ precursor cells.Numb proteins specify asymmetric cell fates via an endocytosis- and proteasome-independent pathway.The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in DrosophilaCharacterization of four mammalian numb protein isoforms. Identification of cytoplasmic and membrane-associated variants of the phosphotyrosine binding domain.Asymmetric cell division in plants: mechanisms of symmetry breaking and cell fate determination.Cellular studies of auditory hair cell regeneration in birdsMammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain.Identification of a new stem cell population that generates Drosophila flight muscles.Membrane targeting and asymmetric localization of Drosophila partner of inscuteable are discrete steps controlled by distinct regions of the protein.A novel transmembrane protein recruits numb to the plasma membrane during asymmetric cell division.Asymmetric cell division of stem cells in the lung and other systems.Stem cell ageing and non-random chromosome segregation.Notch regulates numb: integration of conditional and autonomous cell fate specificationAsymmetric cell division in the Drosophila nervous system.A gain-of-function screen for genes that affect the development of the Drosophila adult external sensory organNotch signaling in hematopoiesis and early lymphocyte development.The Arp2/3 complex and WASp are required for apical trafficking of Delta into microvilli during cell fate specification of sensory organ precursors.Creating asymmetric cell divisions by skewing endocytosis.
P2860
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P2860
The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1996
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
The Drosophila Numb protein in ...... ction in sensory organ lineage
@en
The Drosophila Numb protein in ...... tion in sensory organ lineage.
@nl
type
label
The Drosophila Numb protein in ...... ction in sensory organ lineage
@en
The Drosophila Numb protein in ...... tion in sensory organ lineage.
@nl
prefLabel
The Drosophila Numb protein in ...... ction in sensory organ lineage
@en
The Drosophila Numb protein in ...... tion in sensory organ lineage.
@nl
P2093
P2860
P356
P1476
The Drosophila Numb protein in ...... ction in sensory organ lineage
@en
P2093
P2860
P304
11925-11932
P356
10.1073/PNAS.93.21.11925
P407
P577
1996-10-01T00:00:00Z