Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities
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Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA:DNATwo-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitorsRNase H activity: structure, specificity, and function in reverse transcriptionProcessive phosphorylation of alternative splicing factor/splicing factor 2Ribonuclease H: properties, substrate specificity and roles in retroviral reverse transcriptionMg2+ dependency of HIV-1 reverse transcription, inhibition by nucleoside analogues and resistance.Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease HComplexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradationMechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTPRibonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6Mn2+ suppressor mutations and biochemical communication between Ty1 reverse transcriptase and RNase H domainsCrystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNAMolecular dynamics study of HIV-1 RT-DNA-nevirapine complexes explains NNRTI inhibition and resistance by connection mutationsComparative biochemical analysis of recombinant reverse transcriptase enzymes of HIV-1 subtype B and subtype C.Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptaseMultiple nucleotide preferences determine cleavage-site recognition by the HIV-1 and M-MuLV RNases H.Inhibition of the ribonuclease H activity of HIV-1 reverse transcriptase by GSK5750 correlates with slow enzyme-inhibitor dissociation.Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nefActinomycin D inhibits human immunodeficiency virus type 1 minus-strand transfer in in vitro and endogenous reverse transcriptase assays.Relative rates of retroviral reverse transcriptase template switching during RNA- and DNA-dependent DNA synthesis.Molecular requirements for human immunodeficiency virus type 1 plus-strand transfer: analysis in reconstituted and endogenous reverse transcription systems.Factors that determine the efficiency of HIV-1 strand transfer initiated at a specific siteReplication of phenotypically mixed human immunodeficiency virus type 1 virions containing catalytically active and catalytically inactive reverse transcriptase.RNase H cleavage of the 5' end of the human immunodeficiency virus type 1 genome.Mechanism analysis indicates that recombination events in HIV-1 initiate and complete over short distances, explaining why recombination frequencies are similar in different sections of the genomeMutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture.Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.A succession of mechanisms stimulate efficient reconstituted HIV-1 minus strand strong stop DNA transferDynamic copy choice: steady state between murine leukemia virus polymerase and polymerase-dependent RNase H activity determines frequency of in vivo template switching.Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.HIV-1 Ribonuclease H: Structure, Catalytic Mechanism and Inhibitors.Novel aptamer inhibitors of human immunodeficiency virus reverse transcriptase.Sequence, distance, and accessibility are determinants of 5'-end-directed cleavages by retroviral RNases H.Structural features in the HIV-1 repeat region facilitate strand transfer during reverse transcription.Relationship between plus strand DNA synthesis removal of downstream segments of RNA by human immunodeficiency virus, murine leukemia virus and avian myeloblastoma virus reverse transcriptasesHIV-1 integrase and RNase H activities as therapeutic targets.Selective enhancement of nucleases by polyvalent DNA-functionalized gold nanoparticles.HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.Specific cleavages by RNase H facilitate initiation of plus-strand RNA synthesis by Moloney murine leukemia virus.Requirements for efficient minus strand strong-stop DNA transfer in human immunodeficiency virus 1.
P2860
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P2860
Human immunodeficiency virus type 1 reverse transcriptase: spatial and temporal relationship between the polymerase and RNase H activities
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh
1992年學術文章
@zh-hant
name
Human immunodeficiency virus t ...... ymerase and RNase H activities
@en
Human immunodeficiency virus t ...... merase and RNase H activities.
@nl
type
label
Human immunodeficiency virus t ...... ymerase and RNase H activities
@en
Human immunodeficiency virus t ...... merase and RNase H activities.
@nl
prefLabel
Human immunodeficiency virus t ...... ymerase and RNase H activities
@en
Human immunodeficiency virus t ...... merase and RNase H activities.
@nl
P2093
P2860
P356
P1476
Human immunodeficiency virus t ...... ymerase and RNase H activities
@en
P2093
J A Peliska
S J Benkovic
V Gopalakrishnan
P2860
P304
10763-10767
P356
10.1073/PNAS.89.22.10763
P407
P577
1992-11-01T00:00:00Z