Liddle's syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na(+) channel to the cell surface
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Role of the UPS in Liddle syndromeCa2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cellsCOMMD1 downregulates the epithelial sodium channel through Nedd4-2Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial culturesMultiple WW domains, but not the C2 domain, are required for inhibition of the epithelial Na+ channel by human Nedd4Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channelThe epsin protein family: coordinators of endocytosis and signalingVasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3RNA interference for alpha-ENaC inhibits rat lung fluid absorption in vivoNedd4-2 induces endocytosis and degradation of proteolytically cleaved epithelial Na+ channelsStimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's beta- and gamma-subunitA human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domainA segment of gamma ENaC mediates elastase activation of Na+ transportHrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathwaysAlveolar epithelial transport. Basic science to clinical medicine.Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains.Concerted action of ENaC, Nedd4-2, and Sgk1 in transepithelial Na(+) transport.Cyclic AMP increases cell surface expression of functional Na,K-ATPase units in mammalian cortical collecting duct principal cells.Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC)Genetic variation of the alpha subunit of the epithelial Na+ channel influences exhaled Na+ in healthy humans.Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradationENaC-mediated alveolar fluid clearance and lung fluid balance depend on the channel-activating protease 1.Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways.Alveolar epithelial ion and fluid transport: recent progress.Acute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel pool.Gating induces a conformational change in the outer vestibule of ENaCCFTR: covalent modification of cysteine-substituted channels expressed in Xenopus oocytes shows that activation is due to the opening of channels resident in the plasma membraneEndogenous protease activation of ENaC: effect of serine protease inhibition on ENaC single channel properties.cAMP increases density of ENaC subunits in the apical membrane of MDCK cells in direct proportion to amiloride-sensitive Na(+) transportRegulation of the epithelial Na+ channel by peptidases.The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport.Gene therapy for ALI/ARDS.Effects of baicalin on alveolar fluid clearance and α-ENaC expression in rats with LPS-induced acute lung injury.A regulated NH2-terminal Sgk1 variant with enhanced function is expressed in the collecting duct.Regulation of epithelial Na+ channel (ENaC) in the salivary cell line SMG-C6.An evolutionarily conserved N-terminal Sgk1 variant with enhanced stability and improved function.Plasma membrane insertion of epithelial sodium channels occurs with dual kinetics.Discordant effects of corticosteroids and expression of subunits on ENaC activity.
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Liddle's syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na(+) channel to the cell surface
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on January 2000
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Liddle's syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na
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Liddle's syndrome mutations di ...... +) channel to the cell surface
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type
label
Liddle's syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na
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Liddle's syndrome mutations di ...... +) channel to the cell surface
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prefLabel
Liddle's syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na
@nl
Liddle's syndrome mutations di ...... +) channel to the cell surface
@en
P2860
P356
P1476
Liddle's syndrome mutations di ...... +) channel to the cell surface
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P2093
P M Snyder
P2860
P356
10.1172/JCI7869
P407
P577
2000-01-01T00:00:00Z