Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.
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Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cellsOncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cellsAIDS-associated Kaposi's sarcoma (KS) cells express oncostatin M (OM)-specific receptor but not leukemia inhibitory factor/OM receptor or interleukin-6 receptor. Complete block of OM-induced KS cell growth and OM binding by anti-gp130 antibodiesCloning and expression of an alternatively spliced mRNA encoding a soluble form of the human interleukin-6 signal transducer gp130Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.gp130 and c-Kit signalings synergize for ex vivo expansion of human primitive hemopoietic progenitor cellsRole of monocytes in atherogenesis.Disruption by interferon-alpha of an autocrine interleukin-6 growth loop in IL-6-dependent U266 myeloma cells by homologous and heterologous down-regulation of the IL-6 receptor alpha- and beta-chains.Impairment of antigen-specific antibody production in transgenic mice expressing a dominant-negative form of gp130.Role of the C-terminus in the activity, conformation, and stability of interleukin-6.Interleukin-6: structure-function relationships.Progenitor cell hyperplasia with rare development of myeloid leukemia in interleukin 11 bone marrow chimeras.Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130.Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cellsCNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interactionActivation of Akt through gp130 receptor signaling is required for Kaposi's sarcoma-associated herpesvirus-induced lymphatic reprogramming of endothelial cellsIsolation and characterization of the human gp130 promoter. Regulation by STATS.Cytokine-dependent gp130 receptor subunit regulates human fetal pituitary adrenocorticotropin hormone and growth hormone secretionProliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor.Activity of growth factors in the IL-6 group in the differentiation of human lung adenocarcinoma.C/EBP-related sites in addition to a STAT site are necessary for ciliary neurotrophic factor-leukemia inhibitory factor-dependent transcriptional activation by the vasoactive intestinal peptide cytokine response element.GATA-5 is involved in leukemia inhibitory factor-responsive transcription of the beta-myosin heavy chain gene in cardiac myocytes.The role and therapeutic targeting of IL-6 in rheumatoid arthritis.STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.Cytokine-Like Factor 1, an Essential Facilitator of Cardiotrophin-Like Cytokine:Ciliary Neurotrophic Factor Receptor α Signaling and sorLA-Mediated Turnover.The ability of synoviocytes to support terminal differentiation of activated B cells may explain plasma cell accumulation in rheumatoid synovium.Cytokine signal transduction through a homo- or heterodimer of gp130.Cloning of novel soluble gp130 and detection of its neutralizing autoantibodies in rheumatoid arthritisGeneration of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.Functional and biochemical association of Hck with the LIF/IL-6 receptor signal transducing subunit gp130 in embryonic stem cellsDistinct effects of Broncho-Vaxom (OM-85 BV) on gp130 binding cytokines.Interaction of granulocyte colony-stimulating factor (G-CSF) with its receptor. Evidence that Glu19 of G-CSF interacts with Arg288 of the receptor.Alanine substitution for Thr268 and Asp269 of soluble ciliary neurotrophic factor (CNTF) receptor alpha component defines a specific antagonist for the CNTF response.The expression of IL-6 and its related genes in acute leukemia.Characterization of an interleukin 6 cytokine family antagonist protein from a marine sponge, Callyspongia sp.The signal transducer gp130 is shared by interleukin-6 family of haematopoietic and neurotrophic cytokines.LIF and OM directly interact with a soluble form of gp130, the IL-6 receptor signal transducing subunit.
P2860
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P2860
Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.
description
1992 nî lūn-bûn
@nan
1992年の論文
@ja
1992年学术文章
@wuu
1992年学术文章
@zh-cn
1992年学术文章
@zh-hans
1992年学术文章
@zh-my
1992年学术文章
@zh-sg
1992年學術文章
@yue
1992年學術文章
@zh
1992年學術文章
@zh-hant
name
Functional inhibition of hemat ...... kin 6 signal transducer gp130.
@en
Functional inhibition of hemat ...... kin 6 signal transducer gp130.
@nl
type
label
Functional inhibition of hemat ...... kin 6 signal transducer gp130.
@en
Functional inhibition of hemat ...... kin 6 signal transducer gp130.
@nl
prefLabel
Functional inhibition of hemat ...... kin 6 signal transducer gp130.
@en
Functional inhibition of hemat ...... kin 6 signal transducer gp130.
@nl
P2093
P2860
P356
P1476
Functional inhibition of hemat ...... kin 6 signal transducer gp130.
@en
P2093
Hamaguchi M
Kishimoto T
Narazaki M
Yancopoulos GD
Yasukawa K
P2860
P304
10998-11001
P356
10.1073/PNAS.89.22.10998
P407
P577
1992-11-01T00:00:00Z