Cdk5 and the non-catalytic arrest of the neuronal cell cycle.
about
A Unified Hypothesis of Early- and Late-Onset Alzheimer's Disease PathogenesisThe endocrine dyscrasia that accompanies menopause and andropause induces aberrant cell cycle signaling that triggers re-entry of post-mitotic neurons into the cell cycle, neurodysfunction, neurodegeneration and cognitive diseaseContinued stabilization of the nuclear higher-order structure of post-mitotic neurons in vivoMechanisms of HIV-1 Tat neurotoxicity via CDK5 translocation and hyper-activation: role in HIV-associated neurocognitive disordersUbiquitination of human AP-endonuclease 1 (APE1) enhanced by T233E substitution and by CDK5.CDK5 is present in sea urchin and starfish eggs and embryos and can interact with p35, cyclin E and cyclin B3.Conditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration.Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.Phosphorylation of p27Kip1 at Thr187 by cyclin-dependent kinase 5 modulates neural stem cell differentiation.Cell cycle activation and spinal cord injury.Cyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neuronsThe roles of Cdk5-mediated subcellular localization of FOXO1 in neuronal death.Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase.Cell-intrinsic signals that regulate adult neurogenesis in vivo: insights from inducible approaches.Low Expression of CDK5 and p27 Are Associated with Poor Prognosis in Patients with Gastric Cancer.MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neuronsNucleocytoplasmic protein translocation during mitosis in the social amoebozoan Dictyostelium discoideum.CYY-1/cyclin Y and CDK-5 differentially regulate synapse elimination and formation for rewiring neural circuits.Why Cortical Neurons Cannot Divide, and Why Do They Usually Die in the Attempt?The secret life of kinases: functions beyond catalysisCDK5 phosphorylates DRP1 and drives mitochondrial defects in NMDA-induced neuronal death.The post-mitotic state in neurons correlates with a stable nuclear higher-order structure.Cell cycle activation and CNS injury.
P2860
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P2860
Cdk5 and the non-catalytic arrest of the neuronal cell cycle.
description
2008 nî lūn-bûn
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2008年の論文
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2008年学术文章
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2008年学术文章
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2008年学术文章
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name
Cdk5 and the non-catalytic arrest of the neuronal cell cycle.
@en
Cdk5 and the non-catalytic arrest of the neuronal cell cycle.
@nl
type
label
Cdk5 and the non-catalytic arrest of the neuronal cell cycle.
@en
Cdk5 and the non-catalytic arrest of the neuronal cell cycle.
@nl
prefLabel
Cdk5 and the non-catalytic arrest of the neuronal cell cycle.
@en
Cdk5 and the non-catalytic arrest of the neuronal cell cycle.
@nl
P2860
P356
P1433
P1476
Cdk5 and the non-catalytic arrest of the neuronal cell cycle.
@en
P2093
Karl Herrup
P2860
P304
P356
10.4161/CC.7.22.7045
P577
2008-11-18T00:00:00Z