A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation.

A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation.

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http://www.wikidata.org/entity/Q37323369
Understanding functional residues of the cannabinoid CB1.Computationally-predicted CB1 cannabinoid receptor mutants show distinct patterns of salt-bridges that correlate with their level of constitutive activity reflected in G protein coupling levels, thermal stability, and ligand binding.Allosteric modulator ORG27569 induces CB1 cannabinoid receptor high affinity agonist binding state, receptor internalization, and Gi protein-independent ERK1/2 kinase activationLigand-mimicking receptor variant discloses binding and activation mode of prolactin-releasing peptide.Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor.Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations.Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 ReceptorMapping the structural requirements in the CB1 cannabinoid receptor transmembrane helix II for signal transductionStructural analysis of the human cannabinoid receptor one carboxyl-terminus identifies two amphipathic helices.Type-1 cannabinoid receptor signaling in neuronal development.Assessing Allosteric Modulation of CB1 at the Receptor and Cellular Levels.Retromer stops beta-arrestin 1-mediated signaling from internalized cannabinoid 2 receptors.
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A cannabinoid receptor 1 mutation proximal to the DRY motif results in constitutive activity and reveals intramolecular interactions involved in receptor activation.

Item
http://www.wikidata.org/entity/Q37323369
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on 31 July 2006
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
A cannabinoid receptor 1 mutat ...... volved in receptor activation.
@en
A cannabinoid receptor 1 mutat ...... volved in receptor activation.
@nl
type
label
A cannabinoid receptor 1 mutat ...... volved in receptor activation.
@en
A cannabinoid receptor 1 mutat ...... volved in receptor activation.
@nl
prefLabel
A cannabinoid receptor 1 mutat ...... volved in receptor activation.
@en
A cannabinoid receptor 1 mutat ...... volved in receptor activation.
@nl
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A cannabinoid receptor 1 mutat ...... volved in receptor activation.
@en
P2093
P2860
P304
P31
P356
10.1016/J.BRAINRES.2006.05.042
P407
P433
P478
P577
P5875
P698
P921
P932