The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch
about
Generation and repair of AID-initiated DNA lesions in B lymphocytes.Base excision repair: a critical player in many gamesRegulation of immunoglobulin class-switch recombination: choreography of noncoding transcription, targeted DNA deamination, and long-range DNA repair.Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutationRad9 is required for B cell proliferation and immunoglobulin class switch recombinationp21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.Clustered DNA lesion repair in eukaryotes: relevance to mutagenesis and cell survivalAPOBEC deaminases-mutases with defensive roles for immunity.Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated LesionsNon-canonical uracil processing in DNA gives rise to double-strand breaks and deletions: relevance to class switch recombinationDiverse fates of uracilated HIV-1 DNA during infection of myeloid lineage cells.AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination.DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.A DNA break- and phosphorylation-dependent positive feedback loop promotes immunoglobulin class-switch recombination.The role of activation-induced deaminase in antibody diversification and genomic instability.MBD4 Facilitates Immunoglobulin Class Switch Recombination.Targeting nuclear thymidylate biosynthesis.The Complex Interplay between DNA Injury and Repair in Enzymatically Induced Mutagenesis and DNA Damage in B Lymphocytes.Cytosine deamination and base excision repair cause R-loop-induced CAG repeat fragility and instability in Saccharomyces cerevisiae.R-loops: targets for nuclease cleavage and repeat instability.Generating and repairing genetically programmed DNA breaks during immunoglobulin class switch recombination.
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P2860
The roles of APE1, APE2, DNA polymerase beta and mismatch repair in creating S region DNA breaks during antibody class switch
description
article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on March 2009
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
The roles of APE1, APE2, DNA p ...... s during antibody class switch
@en
The roles of APE1, APE2, DNA p ...... during antibody class switch.
@nl
type
label
The roles of APE1, APE2, DNA p ...... s during antibody class switch
@en
The roles of APE1, APE2, DNA p ...... during antibody class switch.
@nl
prefLabel
The roles of APE1, APE2, DNA p ...... s during antibody class switch
@en
The roles of APE1, APE2, DNA p ...... during antibody class switch.
@nl
P2093
P2860
P356
P1476
The roles of APE1, APE2, DNA p ...... s during antibody class switch
@en
P2093
Janet Stavnezer
Jeroen E J Guikema
Xiaoming Wu
P2860
P304
P356
10.1098/RSTB.2008.0200
P407
P577
2009-03-01T00:00:00Z