Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages. - Wikidata - awgldk - TriplyDB

Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.

Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.

http://www.wikidata.org/entity/Q37337400

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IL-4 and IL-13 signaling in allergic airway disease RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency The differential expression of IL-4 and IL-13 and its impact on type-2 immunity Growth factor and Th2 cytokine signaling pathways converge at STAT6 to promote arginase expression in progressive experimental visceral leishmaniasis Transfer of in vivo primed transgenic T cells supports allergic lung inflammation and FIZZ1 and Ym1 production in an IL-4Rα and STAT6 dependent manner.IL-4 attenuates Th1-associated chemokine expression and Th1 trafficking to inflamed tissues and limits pathogen clearance.The adaptor protein insulin receptor substrate 2 inhibits alternative macrophage activation and allergic lung inflammation In vivo regulation of the allergic response by the IL-4 receptor alpha chain immunoreceptor tyrosine-based inhibitory motif Importance of cytokines in murine allergic airway disease and human asthma.Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.Adoptive transfer of IL-4Rα+ macrophages is sufficient to enhance eosinophilic inflammation in a mouse model of allergic lung inflammation.Expression of IL-4/IL-13 receptors in differentiating human airway epithelial cells.IL-4 engagement of the type I IL-4 receptor complex enhances mouse eosinophil migration to eotaxin-1 in vitro.Absence of the common gamma chain (γ(c)), a critical component of the Type I IL-4 receptor, increases the severity of allergic lung inflammation.Peroxisome proliferator-activated receptor γ deficiency in T cells accelerates chronic rejection by influencing the differentiation of CD4+ T cells and alternatively activated macrophages Monoamine oxidase A (MAO-A): a signature marker of alternatively activated monocytes/macrophages Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury.The Interleukin-13 Receptor-α1 Chain Is Essential for Induction of the Alternative Macrophage Activation Pathway by IL-13 but Not IL-4.Regulation of inflammation by interleukin-4: a review of "alternatives"The extracellular and transmembrane domains of the γC and interleukin (IL)-13 receptor α1 chains, not their cytoplasmic domains, dictate the nature of signaling responses to IL-4 and IL-13.Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells.IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages.Interleukin-4- and interleukin-13-mediated alternatively activated macrophages: roles in homeostasis and disease.Enhanced resolution of experimental ARDS through IL-4-mediated lung macrophage reprogramming Insulin-like growth factor-I serum levels and their biological effects on Leishmania isolates from different clinical forms of American tegumentary leishmaniasis.Accelerated development of pulmonary fibrosis via Cu,Zn-superoxide dismutase-induced alternative activation of macrophages.Cu,Zn-Superoxide Dismutase-Mediated Redox Regulation of Jumonji Domain Containing 3 Modulates Macrophage Polarization and Pulmonary Fibrosis.IL-4 directly signals tissue-resident macrophages to proliferate beyond homeostatic levels controlled by CSF-1 Untangling the complex web of IL-4- and IL-13-mediated signaling pathways.Particles from the Echinococcus granulosus laminated layer inhibit IL-4 and growth factor-driven Akt phosphorylation and proliferative responses in macrophages.mTORC2 signalling regulates M2 macrophage differentiation in response to helminth infection and adaptive thermogenesis Scorpion venom and the inflammatory response.NOX2 deficiency alters macrophage phenotype through an IL-10/STAT3 dependent mechanism: implications for traumatic brain injury Cytokine pathways in allergic disease.Modulation of macrophage activation and programming in immunity.Cytokine stimulation of epithelial cancer cells: the similar and divergent functions of IL-4 and IL-13.Multifarious determinants of cytokine receptor signaling specificity.IL-17A enhances IL-13 activity by enhancing IL-13-induced signal transducer and activator of transcription 6 activation.

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Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.

http://www.wikidata.org/entity/Q37337400

description

article científic

@ca

article scientifique

@fr

articolo scientifico

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artigo científico

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bilimsel makale

@tr

scientific article published on 23 December 2008

@en

vedecký článok

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vetenskaplig artikel

@sv

videnskabelig artikel

@da

vědecký článek

@cs

name

Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.

@en

Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.

@nl

type

label

Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.

@en

Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.

@nl

prefLabel

Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.

@en

Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages.

@nl

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SCISIGNAL.1164795

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Science Signaling

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Type I IL-4Rs selectively activate IRS-2 to induce target gene expression in macrophages

@en

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Achsah D Keegan

http://www.w3.org/2001/XMLSchema#string

Kari Ann Shirey

http://www.w3.org/2001/XMLSchema#string

Nicola M Heller

http://www.w3.org/2001/XMLSchema#string

Stefanie N Vogel

http://www.w3.org/2001/XMLSchema#string

William E Paul

http://www.w3.org/2001/XMLSchema#string

Xiulan Qi

http://www.w3.org/2001/XMLSchema#string

P2860

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

Activation of the SH2-containing protein tyrosine phosphatase, SH-PTP2, by phosphotyrosine-containing peptides derived from insulin receptor substrate-1

Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system

Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling

Role of IRS-2 in insulin and cytokine signalling

FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family

A new mathematical model for relative quantification in real-time RT-PCR

Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

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ra17

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scholarly article

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10.1126/SCISIGNAL.1164795

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51

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2008-12-23T00:00:00Z

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23699321

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19109239

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2739727

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