Loss of leukemogenicity caused by mutations in the membrane glycoprotein structural gene of Friend spleen focus-forming virus.
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Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolismEnv-derived gp55 gene of Friend spleen focus-forming virus specifically induces neoplastic proliferation of erythroid progenitor cells.Friend Spleen Focus-Forming Virus Activates the Tyrosine Kinase sf-Stk and the Transcription Factor PU.1 to Cause a Multi-Stage Erythroleukemia in Mice.Cell surface activation of the erythropoietin receptor by Friend spleen focus-forming virus gp55.The endogenous mink cell focus-forming (MCF) gp70 linked to the Rmcf gene restricts MCF virus replication in vivo and provides partial resistance to erythroleukemia induced by Friend murine leukemia virus.Mechanism of leukemogenesis induced by mink cell focus-forming murine leukemia viruses.Mutations in the env gene of friend spleen focus-forming virus overcome Fv-2r-mediated resistance to Friend virus-induced erythroleukemia.A deletion in the Friend spleen focus-forming virus env gene is necessary for its product (gp55) to be leukemogenic.Influence of murine leukemia proviral integrations on development of N-methyl-N-nitrosourea-induced thymic lymphomas in AKR mice.Loss of pathogenicity of spleen focus-forming virus after pseudotyping with AkvLeukemogenic membrane glycoprotein encoded by Friend spleen focus-forming virus: transport to cell surfaces and shedding are controlled by disulfide-bonded dimerization and by cleavage of a hydrophobic membrane anchor.Requirement of the single base insertion at the 3' end of the env-related gene of Friend spleen focus-forming virus for pathogenic activity and its effect on localization of the glycoprotein product (gp55).Roles of helper and defective retroviral genomes in murine erythroleukemia: studies of spleen focus-forming virus in the absence of helper.Role of a membrane glycoprotein in Friend virus erythroleukemia: nucleotide sequences of nonleukemogenic mutant and spontaneous revertant viruses.The spleen focus-forming virus (SFFV) envelope gene, when introduced into mice in the absence of other SFFV genes, induces acute erythroleukemia.A tagged helper-free Friend virus causes clonal erythroblast immortality by specific proviral integration in the cellular genome.Genetic determinants of neoplastic diseases induced by a subgroup F avian leukosis virusA weakly pathogenic Rauscher spleen focus-forming virus mutant that lacks the carboxyl-terminal membrane anchor of its envelope glycoprotein.Envelope gene and long terminal repeat determine the different biological properties of Rauscher, Friend, and Moloney mink cell focus-inducing virusesProviral genome of radiation leukemia virus: molecular cloning of biologically active proviral DNA and nucleotide sequence of its long terminal repeatReduced leukemogenicity caused by mutations in the membrane glycoprotein gene of Rauscher spleen focus-forming virus.The membrane glycoprotein of Friend spleen focus-forming virus: evidence that the cell surface component is required for pathogenesis and that it binds to a receptor.A membrane-associated, carbohydrate-modified form of the v-abl protein that cannot be phosphorylated in vivo or in vitroMolecular cloning of biologically active Rauscher spleen focus-forming virus and the sequences of its env gene and long terminal repeat.Intracellular transport and leukemogenicity of spleen focus-forming virus envelope glycoproteins with altered transmembrane domainsFrequent hereditable shutdown of murine retrovirus gene expression in murine cell linesMulti-stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation.c-myc protooncogene expression in mouse erythroleukemia cells.Erythropoietin receptor (EpoR)-dependent mitogenicity of spleen focus-forming virus correlates with viral pathogenicity and processing of env protein but not with formation of gp52-EpoR complexes in the endoplasmic reticulum.Characterization of variable regions in the envelope and S3 open reading frame of equine infectious anemia virus.Cell surface organization of the erythropoietin receptor complex differs depending on its mode of activation.Basic helix-loop-helix proteins in murine type C retrovirus transcriptional regulation.
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P2860
Loss of leukemogenicity caused by mutations in the membrane glycoprotein structural gene of Friend spleen focus-forming virus.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1983
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Loss of leukemogenicity caused ...... nd spleen focus-forming virus.
@en
Loss of leukemogenicity caused ...... nd spleen focus-forming virus.
@nl
type
label
Loss of leukemogenicity caused ...... nd spleen focus-forming virus.
@en
Loss of leukemogenicity caused ...... nd spleen focus-forming virus.
@nl
prefLabel
Loss of leukemogenicity caused ...... nd spleen focus-forming virus.
@en
Loss of leukemogenicity caused ...... nd spleen focus-forming virus.
@nl
P2093
P2860
P356
P1476
Loss of leukemogenicity caused ...... nd spleen focus-forming virus.
@en
P2093
P2860
P304
P356
10.1073/PNAS.80.15.4704
P407
P577
1983-08-01T00:00:00Z