Envelope gene of the Friend spleen focus-forming virus: deletion and insertions in 3' gp70/p15E-encoding region have resulted in unique features in the primary structure of its protein product
about
Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndromeActivation of the N-terminally truncated form of the Stk receptor tyrosine kinase Sf-Stk by Friend virus-encoded gp55 is mediated by cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-Stk.Precise identification of endogenous proviruses of NFS/N mice participating in recombination with moloney ecotropic murine leukemia virus (MuLV) to generate polytropic MuLVs.Sequence flexibility in the polytropic env gp70-derived region of the membrane glycoprotein (gp55) of Friend spleen focus-forming virus affects its biological activity.Origin and rapid evolution of a novel murine erythroleukemia virus of the spleen focus-forming virus family.An array of novel murine spleen focus-forming viruses that activate the erythropoietin receptor.A novel truncated env gene isolated from a feline leukemia virus-induced thymic lymphosarcoma.Establishment of monoclonal anti-retroviral gp70 autoantibodies from MRL/lpr lupus mice and induction of glomerular gp70 deposition and pathology by transfer into non-autoimmune mice.The envelope glycoprotein of friend spleen focus-forming virus covalently interacts with and constitutively activates a truncated form of the receptor tyrosine kinase Stk.Env-derived gp55 gene of Friend spleen focus-forming virus specifically induces neoplastic proliferation of erythroid progenitor cells.Helix packing and orientation in the transmembrane dimer of gp55-P of the spleen focus forming virus.Friend Spleen Focus-Forming Virus Activates the Tyrosine Kinase sf-Stk and the Transcription Factor PU.1 to Cause a Multi-Stage Erythroleukemia in Mice.Deletions in one domain of the Friend virus-encoded membrane glycoprotein overcome host range restrictions for erythroleukemia.Novel retroviral vectors for efficient expression of the multidrug resistance (mdr-1) gene in early hematopoietic cells.Expression of a constitutively active erythropoietin receptor in primary hematopoietic progenitors abrogates erythropoietin dependence and enhances erythroid colony-forming unit, erythroid burst-forming unit, and granulocyte/macrophage progenitor grFriend virus-specific cytotoxic T lymphocytes recognize both gag and env gene-encoded specificitiesA Friend virus mutant encodes a small glycoprotein that causes erythroleukemia.Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells.Conversion of Friend mink cell focus-forming virus to Friend spleen focus-forming virus by modification of the 3' half of the env gene.Mechanism of leukemogenesis induced by mink cell focus-forming murine leukemia viruses.Mutations in the env gene of friend spleen focus-forming virus overcome Fv-2r-mediated resistance to Friend virus-induced erythroleukemia.A neutralizable epitope common to the envelope glycoproteins of ecotropic, polytropic, xenotropic, and amphotropic murine leukemia viruses.The hydrophobic membrane-spanning sequences of the gp52 glycoprotein are required for the pathogenicity of Friend spleen focus-forming virus.A deletion in the Friend spleen focus-forming virus env gene is necessary for its product (gp55) to be leukemogenic.The erythropoietin receptor transmembrane region is necessary for activation by the Friend spleen focus-forming virus gp55 glycoprotein.Loss of pathogenicity of spleen focus-forming virus after pseudotyping with AkvLeukemogenic membrane glycoprotein encoded by Friend spleen focus-forming virus: transport to cell surfaces and shedding are controlled by disulfide-bonded dimerization and by cleavage of a hydrophobic membrane anchor.Requirement of the single base insertion at the 3' end of the env-related gene of Friend spleen focus-forming virus for pathogenic activity and its effect on localization of the glycoprotein product (gp55).Analysis of integrated proviral DNA sequences with an octadecanucleotide probe designed for specific identification of spleen focus-forming virus in the mouse genomeRole of a membrane glycoprotein in Friend virus erythroleukemia: nucleotide sequences of nonleukemogenic mutant and spontaneous revertant viruses.Specific hybridization probes demonstrate fewer xenotropic than mink cell focus-forming murine leukemia virus env-related sequences in DNAs from inbred laboratory miceThe spleen focus-forming virus (SFFV) envelope gene, when introduced into mice in the absence of other SFFV genes, induces acute erythroleukemia.The 3' long terminal repeat of a transcribed yet defective endogenous retroviral sequence is a competent promoter of transcription.Heteroduplex analysis of molecular clones of the pathogenic Friend virus complex: Friend murine leukemia virus, Friend mink cell focus-forming virus, and the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus.Sequence comparisons of the anemia- and polycythemia-inducing strains of Friend spleen focus-forming virus.A weakly pathogenic Rauscher spleen focus-forming virus mutant that lacks the carboxyl-terminal membrane anchor of its envelope glycoprotein.Envelope gene sequence of two in vitro-generated mink cell focus-forming murine leukemia viruses which contain the entire gp70 sequence of the endogenous nonecotropic parent.Characterization of the env gene and long terminal repeat of molecularly cloned Friend mink cell focus-inducing virus DNAThe membrane glycoprotein of Friend spleen focus-forming virus: evidence that the cell surface component is required for pathogenesis and that it binds to a receptor.Molecular cloning of biologically active Rauscher spleen focus-forming virus and the sequences of its env gene and long terminal repeat.
P2860
Q28260932-8002E8BA-B3CC-4C0E-A547-B4943E5D7AEEQ33648896-FB9C7B35-3AE5-4868-A288-50476D176360Q33724241-F2A0EDA0-E20B-4F24-B082-9EFB0706BD43Q33782454-A8C06113-742B-40D4-8818-F4559B7BF2CEQ33782598-11D48995-D9A1-48DE-A979-C782719AF48AQ33782640-7D968246-3415-42C8-A311-DC6D0300A7C2Q33793617-9EB8D54F-4E24-4C27-94E6-7912DFD32646Q33803417-40255F27-3255-46C5-9D25-8AFD23120B99Q33853516-017AF0D9-F7B3-4C64-93DC-6E9671F56906Q33920536-83B60290-0ECC-44A7-A100-B45D2481EA55Q34350760-5DB2CC0A-DBE8-40C5-B393-76E4B9DA5E44Q35260352-30E21216-6607-4C67-A68A-EE887FE6142BQ35831703-0E602CAB-9265-4CEC-92CA-266E6D1D0D8EQ35851842-8A149DA2-3C11-4740-9CBC-C1E9172B2241Q36082271-A0BB14AD-DA7A-430A-AE16-C041CB19D761Q36352191-21800A0B-1941-4518-884E-1D1778022F41Q36634561-430EE063-475B-439F-A47F-DC40DCF9D97AQ36650857-6AD216A9-FAD0-4960-9E17-AE37F55476ABQ36687831-E3E02F04-4BD8-4209-80AE-5EB5EDF74B53Q36688798-0D36979F-B127-43C2-A0A8-E05D09C08E9CQ36698134-8E8417B5-0F2D-49B1-9DD1-3CDCF87EA600Q36796266-EFCB1ECF-3DC8-4516-88EA-0C8C82AF58BAQ36798066-1DC6BA20-69A0-4FDA-9A72-5C0BDDB19CC7Q36806961-F16EB9EE-23B1-498F-8A63-36976C3BFFBDQ36818583-81F487AE-C9FA-497D-82E8-A329F2EBC8F6Q36826874-3AF8FAA3-7CC1-479D-935D-E429FB10379FQ36830113-5D520FC2-658C-410F-8586-32BD37C034D5Q36831690-11D13105-99B8-4DF4-8052-E39AC0E13B8EQ36856640-88627D7D-FF7A-480B-BBBD-4D5D629C8127Q36857615-159B1BD8-8381-438D-8060-3FF319A41BAEQ36862156-8055E448-EFF5-4374-9B91-6C76F7768A64Q36869795-290262CC-7AED-46DE-A932-10BD7CDCEB85Q36886863-685C936E-DBA2-44A5-95D4-2A5EB6E46624Q36892955-0DF54552-AE81-4BBA-B3FB-4FD916281B31Q36898164-D99A8DE2-96DD-4278-B41B-11A385CDF325Q36899775-EA4EC7A7-6370-4AA3-B697-9876ED35E080Q36912189-6276682D-56FA-4923-A847-2BE0049ADB1DQ36917549-96C0CC3F-5103-4DBE-8DCA-9E1CFCC4C947Q36918582-3E76C281-9E6F-45C6-AFA9-EDD39A0C3EE7Q36918901-3B8E4FD0-7FDB-4C73-92DF-054FD3243603
P2860
Envelope gene of the Friend spleen focus-forming virus: deletion and insertions in 3' gp70/p15E-encoding region have resulted in unique features in the primary structure of its protein product
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1983
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Envelope gene of the Friend sp ...... ructure of its protein product
@en
Envelope gene of the Friend sp ...... ucture of its protein product.
@nl
type
label
Envelope gene of the Friend sp ...... ructure of its protein product
@en
Envelope gene of the Friend sp ...... ucture of its protein product.
@nl
prefLabel
Envelope gene of the Friend sp ...... ructure of its protein product
@en
Envelope gene of the Friend sp ...... ucture of its protein product.
@nl
P2093
P2860
P356
P1476
Envelope gene of the Friend sp ...... ructure of its protein product
@en
P2093
P2860
P304
P356
10.1073/PNAS.80.15.4718
P407
P577
1983-08-01T00:00:00Z