Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562.
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The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemiaThe chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcriptGlobin gene expression in erythroid human fetal liver cellsThe Philadelphia chromosome in leukemogenesisMolecular cloning of a human immunoglobulin lambda chain variable sequenceHuman chromosome 22.Induction of erythroid differentiation and modulation of gene expression by tiazofurin in K-562 leukemia cells.bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice.Chronic myelogenous leukemia--recent advances in treatment and pathogenesis.Recombinant tumor necrosis factor alpha and interleukin 1 alpha increase expression of c-abl protooncogene mRNA in cultured human marrow stromal cells.Breakpoints on chromosomes 9 and 22 in Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Amplification of rearranged c-abl oncogenes in CML blast crisis.Localization of gelsolin proximal to ABL on chromosome 9Amplification units containing human N-myc and c-myc genesv-abl activates embryonic globin gene expression in mouse erythroleukemia cells.Variable expression of the translocated c-abl oncogene in Philadelphia-chromosome-positive B-lymphoid cell lines from chronic myelogenous leukemia patientsProgressive de novo DNA methylation at the bcr-abl locus in the course of chronic myelogenous leukemia.Replication of proto-oncogenes early during the S phase in mammalian cell lines.Aberrant expression of an amplified c-myb oncogene in two cell lines from a colon carcinoma.T cell receptor and immunoglobulin gene rearrangements in acute myeloblastic leukemia.Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase propertiesStructure and localization of genes encoding aberrant and normal epidermal growth factor receptor RNAs from A431 human carcinoma cells.Expression of bcr and bcr-abl fusion transcripts in normal and leukemic cells.UV radiation facilitates methotrexate resistance and amplification of the dihydrofolate reductase gene in cultured 3T6 mouse cells.A 41-kilodalton protein is a potential substrate for the p210bcr-abl protein-tyrosine kinase in chronic myelogenous leukemia cells.Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases.Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cellsThe TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions.Enhanced expression of the human gene N-myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma.An 8-kilobase abl RNA transcript in chronic myelogenous leukemia.TPR-MET oncogenic rearrangement: detection by polymerase chain reaction amplification of the transcript and expression in human tumor cell lines.Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.Normal diploid human and rodent cells lack a detectable frequency of gene amplification.Oncogenes in human leukemias.The Use of Genetic Markers in Studies of Myeloid Neoplasia.Human cancer and cellular oncogenes.Activation of cellular oncogenes in human and mouse leukemia-lymphomas: spontaneous and induced oncogene expression in murine B lymphocytic neoplasms.The molecular biology of chronic myelogenous leukaemia.trans-activation of the simian virus 40 enhancer by a pX product of human T-cell leukemia virus type I.Regional mapping of two human immunoglobulin V lambda genes and analysis of the V lambda locus in chronic myeloid leukaemia.
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P2860
Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on August 1983
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Rearrangement and amplificatio ...... nous leukemia cell line K-562.
@en
Rearrangement and amplificatio ...... nous leukemia cell line K-562.
@nl
type
label
Rearrangement and amplificatio ...... nous leukemia cell line K-562.
@en
Rearrangement and amplificatio ...... nous leukemia cell line K-562.
@nl
prefLabel
Rearrangement and amplificatio ...... nous leukemia cell line K-562.
@en
Rearrangement and amplificatio ...... nous leukemia cell line K-562.
@nl
P2860
P356
P1476
Rearrangement and amplificatio ...... nous leukemia cell line K-562.
@en
P2093
Collins SJ
Groudine MT
P2860
P304
P356
10.1073/PNAS.80.15.4813
P407
P577
1983-08-01T00:00:00Z