Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.
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Mechanism of activation of the human trk oncogeneInterferon-inducible gene maps to a chromosomal band associated with a (4;11) translocation in acute leukemia cellsNucleotide sequence of testis-derived c-abl cDNAs: implications for testis-specific transcription and abl oncogene activationFunctional mechanisms and roles of adaptor proteins in abl-regulated cytoskeletal actin dynamics.Human chromosome 22.Molecular mechanisms of cancer.Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer.Localization of preferential sites of rearrangement within the BCR gene in Philadelphia chromosome-positive acute lymphoblastic leukemiaUnexpected heterogeneity of BCR-ABL fusion mRNA detected by polymerase chain reaction in Philadelphia chromosome-positive acute lymphoblastic leukemiaThe molecular biology of chromosome alterations in myelogenous leukemia.Breakpoints on chromosomes 9 and 22 in Philadelphia chromosome-positive chronic myelogenous leukemia (CML). Amplification of rearranged c-abl oncogenes in CML blast crisis.Cell lines and peripheral blood leukocytes derived from individuals with chronic myelogenous leukemia display virtually identical proteins phosphorylated on tyrosine residuesModelling haematopoietic malignancies in the mouse and therapeutical implications.Philadelphia Chromosome Symposium: commemoration of the 50th anniversary of the discovery of the Ph chromosomePhiladelphia-positive leukemia: a personal perspective.Our changing view of the genomic landscape of cancer.Tyrosine kinase inhibitors as cancer therapy.Secondary activation of c-abl may be related to translocation to the nucleolar organizer region in an in vitro cultured rat leukemia cell line (K3D)v-abl activates embryonic globin gene expression in mouse erythroleukemia cells.Restriction fragment length polymorphism caused by a deletion within the human c-abl gene (ABL).Variable expression of the translocated c-abl oncogene in Philadelphia-chromosome-positive B-lymphoid cell lines from chronic myelogenous leukemia patientsUnregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells.Cytogenetic abnormalities in childhood acute lymphoblastic leukemia correlates with clinical features and treatment outcome.Tyrosine protein kinase activity in normal and leukaemic human blood cells.A streamlined method for detecting structural variants in cancer genomes by short read paired-end sequencingDifferences in oncogenic potency but not target cell specificity distinguish the two forms of the BCR/ABL oncogeneChronic myeloid leukaemia following repeated exposure to chest radiography and computed tomography in a patient with pneumothorax: A case report and literature review.The BCR-ABL oncogene transforms Rat-1 cells and cooperates with v-myc.The 5' noncoding region of the human leukemia-associated oncogene BCR/ABL is a potent inhibitor of in vitro translation.Phosphotyrosine antibodies identify the p210c-abl tyrosine kinase and proteins phosphorylated on tyrosine in human chronic myelogenous leukemia cellsExpression of bcr and bcr-abl fusion transcripts in normal and leukemic cells.Normal cellular and transformation-associated abl proteins share common sites for protein kinase C phosphorylation.Detection of c-abl tyrosine kinase activity in vitro permits direct comparison of normal and altered abl gene productsGenetic and environmental modulations of chromosomal stability: their roles in aging and oncogenesis.Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas."Replacement" of COOH-terminal truncation of v-fms with c-fms sequences markedly reduces transformation potential.Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.Chromosomal localization and characterization of c-abl in the t(6;9) of acute nonlymphocytic leukemiaMolecular relapse in chronic myelogenous leukemia patients after bone marrow transplantation detected by polymerase chain reaction.ABL1 fusion genes in hematological malignancies: a review.
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P2860
Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on March 1985
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Cell lines and clinical isolat ...... common structural alteration.
@en
Cell lines and clinical isolat ...... common structural alteration.
@nl
type
label
Cell lines and clinical isolat ...... common structural alteration.
@en
Cell lines and clinical isolat ...... common structural alteration.
@nl
prefLabel
Cell lines and clinical isolat ...... common structural alteration.
@en
Cell lines and clinical isolat ...... common structural alteration.
@nl
P2093
P2860
P4510
P921
P356
P1476
Cell lines and clinical isolat ...... common structural alteration.
@en
P2093
J B Konopka
J W Singer
S J Collins
S M Watanabe
P2860
P304
P356
10.1073/PNAS.82.6.1810
P407
P577
1985-03-01T00:00:00Z