Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. - Wikidata - awgldk - TriplyDB

Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants.

Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants.

http://www.wikidata.org/entity/Q37352307

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Cerulein pancreatitis: oxidative stress, inflammation, and apoptosis Imaging free radicals in organelles, cells, tissue, and in vivo with immuno-spin trapping ALS Patient Stem Cells for Unveiling Disease Signatures of Motoneuron Susceptibility: Perspectives on the Deadly Mitochondria, ER Stress and Calcium Triad An Overview of Potential Targets for Treating Amyotrophic Lateral Sclerosis and Huntington's Disease Elusive roles for reactive astrocytes in neurodegenerative diseases Molecular motor proteins and amyotrophic lateral sclerosis Mitochondrial dysfunction in amyotrophic lateral sclerosis - a valid pharmacological target?Role of NMDA Receptor-Mediated Glutamatergic Signaling in Chronic and Acute Neuropathologies Targeting Glial Mitochondrial Function for Protection from Cerebral Ischemia: Relevance, Mechanisms, and the Role of MicroRNAs The complex molecular biology of amyotrophic lateral sclerosis (ALS)Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases Lead exposure stimulates VEGF expression in the spinal cord and extends survival in a mouse model of ALS Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration.c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis.Altered Metabolic Profiles Associate with Toxicity in SOD1G93A Astrocyte-Neuron Co-Cultures.A role for copper in the toxicity of zinc-deficient superoxide dismutase to motor neurons in amyotrophic lateral sclerosis The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression Free radical-operated proteotoxic stress in macrophages primed with lipopolysaccharide.Immuno-spin trapping from biochemistry to medicine: advances, challenges, and pitfalls. Focus on protein-centered radicals Measures of bulbar and spinal motor function, muscle innervation, and mitochondrial function in ALS rats.Ginsenoside Rd attenuates mitochondrial permeability transition and cytochrome C release in isolated spinal cord mitochondria: involvement of kinase-mediated pathways.Stem cell-derived motor neurons: applications and challenges in amyotrophic lateral sclerosis.Neonatal astrocyte damage is sufficient to trigger progressive striatal degeneration in a rat model of glutaric acidemia-I.Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis.Effects of natural antioxidants in neurodegenerative disease.Expression of zinc-deficient human superoxide dismutase in Drosophila neurons produces a locomotor defect linked to mitochondrial dysfunction.Nitric oxide-mediated oxidative damage and the progressive demise of motor neurons in ALS.Mitochondrial dysfunction and intracellular calcium dysregulation in ALS Catalytic antioxidants and neurodegeneration Potential therapeutic benefits of strategies directed to mitochondria.Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS Expression of a pathogenic mutation of SOD1 sensitizes aprataxin-deficient cells and mice to oxidative stress and triggers hallmarks of premature ageing.Functional mitochondrial analysis in acute brain sections from adult rats reveals mitochondrial dysfunction in a rat model of migraine.Oxidative stress induces protein and DNA radical formation in follicular dendritic cells of the germinal center and modulates its cell death patterns in late sepsis Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity.Mitochondria-targeted catalase reverts the neurotoxicity of hSOD1G⁹³A astrocytes without extending the survival of ALS-linked mutant hSOD1 mice Phenotypically aberrant astrocytes that promote motoneuron damage in a model of inherited amyotrophic lateral sclerosis Mitochondria-targeted nitroxides exacerbate fluvastatin-mediated cytostatic and cytotoxic effects in breast cancer cells Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy

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Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants.

http://www.wikidata.org/entity/Q37352307

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bilimsel makale

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scientific article published on April 2008

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Mitochondrial dysfunction in S ...... ondrial-targeted antioxidants.

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Mitochondrial dysfunction in S ...... ondrial-targeted antioxidants.

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Mitochondrial dysfunction in S ...... ondrial-targeted antioxidants.

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Mitochondrial dysfunction in S ...... ondrial-targeted antioxidants.

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Mitochondrial dysfunction in S ...... ondrial-targeted antioxidants.

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JNEUROSCI.5308-07.2008

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Journal of Neuroscience

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Mitochondrial dysfunction in S ...... ondrial-targeted antioxidants.

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Adriana Cassina

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Andrés de León

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Joseph S Beckman

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Kristine M Robinson

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Luis Barbeito

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Mandi Gandelman

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Mariana Pehar

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Patricia Cassina

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Rafael Radi

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Raquel Castellanos

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P2860

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Immunological identification of the heart myoglobin radical formed by hydrogen peroxide

Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS

Peroxynitrite reactions and formation in mitochondria

Unraveling the mechanisms involved in motor neuron degeneration in ALS

Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties.

Using anti-5,5-dimethyl-1-pyrroline N-oxide (anti-DMPO) to detect protein radicals in time and space with immuno-spin trapping.

Mitochondrial proteomic analysis of a cell line model of familial amyotrophic lateral sclerosis.

Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection.

Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS).

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4115-4122

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10.1523/JNEUROSCI.5308-07.2008

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2008-04-01T00:00:00Z

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18417691

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