Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.
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Deficient spindle assembly checkpoint in multiple myelomaInhibition of TRIP1/S8/hSug1, a component of the human 19S proteasome, enhances mitotic apoptosis induced by spindle poisonsLethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.The role of aneuploidy in promoting and suppressing tumorsMad2 overexpression promotes aneuploidy and tumorigenesis in miceMAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formationSmall-molecule kinase inhibitors provide insight into Mps1 cell cycle functionNovel sfi1 alleles uncover additional functions for Sfi1p in bipolar spindle assembly and function.Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosisIn-silico modeling of the mitotic spindle assembly checkpointSpindle assembly checkpoint regulates mitotic cell cycle progression during preimplantation embryo developmentUSP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesisG2/M Cell Cycle Arrest and Tumor Selective Apoptosis of Acute Leukemia Cells by a Promising Benzophenone Thiosemicarbazone CompoundEarly aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice.The HECT E3 ligase Smurf2 is required for Mad2-dependent spindle assembly checkpointChromosome missegregation rate predicts whether aneuploidy will promote or suppress tumors.Unliganded progesterone receptors attenuate taxane-induced breast cancer cell death by modulating the spindle assembly checkpointMultiple mechanisms determine the order of APC/C substrate degradation in mitosis.Inducible microRNA expression by an all-in-one episomal vector system.Uncoupling anaphase-promoting complex/cyclosome activity from spindle assembly checkpoint control by deregulating polo-like kinase 1.Disruption of FAT10-MAD2 binding inhibits tumor progression.The MPS1 family of protein kinases.MicroRNA 28 controls cell proliferation and is down-regulated in B-cell lymphomas.Pellino 1 inactivates mitotic spindle checkpoint by targeting BubR1 for ubiquitinational degradation.Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytesA zebrafish bmyb mutation causes genome instability and increased cancer susceptibility.Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazoleSecurin and separase phosphorylation act redundantly to maintain sister chromatid cohesion in mammalian cells.Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles.Mad2 checkpoint gene silencing using epidermal growth factor receptor-targeted chitosan nanoparticles in non-small cell lung cancer model.Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.Cell-based expression cloning for identification of polypeptides that hypersensitize mammalian cells to mitotic arrest.Mad2 is a critical mediator of the chromosome instability observed upon Rb and p53 pathway inhibition.Aneuploidy: instigator and inhibitor of tumorigenesis.Mad2 is required for optimal hematopoiesis: Mad2 associates with c-Kit in MO7e cellsKey role of dual specificity kinase TTK in proliferation and survival of pancreatic cancer cells.Killing cells by targeting mitosisOncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors.A leukemia fusion protein attenuates the spindle checkpoint and promotes aneuploidySurveillance mechanism linking Bub1 loss to the p53 pathway.
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P2860
Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.
description
article científic
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article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
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scientific article published on 15 March 2004
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Complete loss of the tumor sup ...... ailure in human somatic cells.
@en
Complete loss of the tumor sup ...... ailure in human somatic cells.
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type
label
Complete loss of the tumor sup ...... ailure in human somatic cells.
@en
Complete loss of the tumor sup ...... ailure in human somatic cells.
@nl
prefLabel
Complete loss of the tumor sup ...... ailure in human somatic cells.
@en
Complete loss of the tumor sup ...... ailure in human somatic cells.
@nl
P2093
P2860
P356
P1476
Complete loss of the tumor sup ...... failure in human somatic cells
@en
P2093
Gopeshwar Narayan
Loren Michel
Robert Benezra
Vundavalli V V S Murty
P2860
P304
P356
10.1073/PNAS.0306069101
P407
P577
2004-03-15T00:00:00Z