Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes. - Wikidata - awgldk - TriplyDB

Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.

Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.

http://www.wikidata.org/entity/Q37360179

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Oncogenes induce the cancer-associated fibroblast phenotype: metabolic symbiosis and "fibroblast addiction" are new therapeutic targets for drug discovery Current advances in biomarkers for targeted therapy in triple-negative breast cancer Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies Use of DNA-damaging agents and RNA pooling to assess expression profiles associated with BRCA1 and BRCA2 mutation status in familial breast cancer patients.MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ERα)-positive mammary adenocarcinomas.Germline variation controls the architecture of somatic alterations in tumors Lack of genomic heterogeneity at high-resolution aCGH between primary breast cancers and their paired lymph node metastases Genomic instability in breast cancer: pathogenesis and clinical implications Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer.Proteomics and ovarian cancer: integrating proteomics information into clinical care Pancreatic adenocarcinoma Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations.Poly (ADP-ribose) polymerase as a novel therapeutic target in cancer.Deletion of chromosomes 13q and 14q is a common feature of tumors with BRCA2 mutations.A genomic instability score in discriminating nonequivalent outcomes of BRCA1/2 mutations and in predicting outcomes of ovarian cancer treated with platinum-based chemotherapy Identification by array comparative genomic hybridization of a new amplicon on chromosome 17q highly recurrent in BRCA1 mutated triple negative breast cancer.CpG island hypermethylation of BRCA1 and loss of pRb as co-occurring events in basal/triple-negative breast cancer.Drug therapy for hereditary cancers Copy number imbalances between screen- and symptom-detected breast cancers and impact on disease-free survival.Genomic and phenotypic analysis of BRCA2 mutated breast cancers reveals co-occurring changes linked to progression.Companion diagnostics: changing patient management Different Array CGH profiles within hereditary breast cancer tumors associated to BRCA1 expression and overall survival Identification of BRCA1-like triple-negative breast cancers by quantitative multiplex-ligation-dependent probe amplification (MLPA) analysis of BRCA1-associated chromosomal regions: a validation study.BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control.Analysis of terminal duct lobular unit involution in luminal A and basal breast cancers.Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer.BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies.Ovarian cancer: can proteomics give new insights for therapy and diagnosis?Aurora A is a prognostic marker for breast cancer arising in BRCA2 mutation carriers.DNA copy number profiling reveals extensive genomic loss in hereditary BRCA1 and BRCA2 ovarian carcinomas.BRCA1 and BRCA2: different roles in a common pathway of genome protection.Genomic architecture characterizes tumor progression paths and fate in breast cancer patients.Chemoprevention of Rat Mammary Carcinogenesis by Apiaceae Spices Targeting tumour-initiating cells to improve the cure rates for triple-negative breast cancer.Genomic instability in breast and ovarian cancers: translation into clinical predictive biomarkers.BRACking news on triple-negative/basal-like breast cancers: how BRCA1 deficiency may result in the development of a selective tumor subtype.Preoperative systemic therapy in locoregional management of early breast cancer: highlights from the Kyoto Breast Cancer Consensus Conference.The 11q13-q14 amplicon: clinicopathological correlations and potential drivers.Predictive biomarkers for cancer therapy with PARP inhibitors.The EMSY threonine 207 phospho-site is required for EMSYdriven suppression of DNA damage repair.

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Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.

http://www.wikidata.org/entity/Q37360179

description

article científic

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article scientifique

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articolo scientifico

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artigo científico

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bilimsel makale

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scientific article published on 09 July 2009

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vedecký článok

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vetenskaplig artikel

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videnskabelig artikel

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vědecký článek

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name

Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.

@en

Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.

@nl

type

label

Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.

@en

Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.

@nl

prefLabel

Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.

@en

Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.

@nl

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Breast Cancer Research

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Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.

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Jon Gunnlaugur Jonasson

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Jorunn Erla Eyfjord

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Kristrun Olafsdottir

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Margret Steinarsdottir

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Olafur Andri Stefansson

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Oskar Thor Johannsson

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Sigridur Valgeirsdottir

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Bioconductor: open software development for computational biology and bioinformatics

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

Identifying biological themes within lists of genes with EASE

Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

Gene expression profiling predicts clinical outcome of breast cancer

Molecular portraits of human breast tumours

EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer

Basal-like breast cancer defined by five biomarkers has superior prognostic value than triple-negative phenotype

Circular binary segmentation for the analysis of array-based DNA copy number data

Genomic and transcriptional aberrations linked to breast cancer pathophysiologies

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10.1186/BCR2334

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